Pathological changes in the acute phase of streptozotocin-induced diabetic rats

• Autorzy: Ozdermir O. , Akalin P. P. , Baspinar N. , Hatipoglu F.
• Języki publikacji: EN

Abstrakty

EN

This study aimed at investigating the acute phase of pathological changes in streptozotocin-induced diabetic rats with varying glucose levels. Eighteen rats, six control, six D1 group (with glucose level of 200-300 mg/dl), and six D2 group (with glucose level over 300 mg/dl), were used. They were euthanasied on the 14th d after streptozotocin administration. Samples taken from internal organs were examined under a light microscope after routine histopathology processes. The changes in the organs were scored as light, mild and severe. The glomerulus, Bowman's space, and renal corpuscle areas were calculated. There were significant differences between THE diabetic groups and control in terms of degenerative lesions in the pancreas, liver, spleen, and kidneys. It was found that increasing the area of Bowman's space was directly proportional to blood glucose level. There was a significant difference between D1 and D2 in terms of the number of apoptotic cells in the spleen and there was an increase in apoptosis. It was concluded that the increased width of the Bowman's space in the acute phase of type-I diabetes, and the changes observed in the other organs, would be useful for further studies on diabetes.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2009
• Tom: 53
• Numer: 4
• Opis fizyczny: p.783-790, fig.,ref.

Twórcy

autor

Ozdermir O.

• Department of Pathology, University of Selcuk, 42079, Konya, Turkey

autor

Akalin P. P.

• Department of Biochemistry, Faculty of Veterinary Medicine, University of Selcuk, 42079, Konya, Turkey

autor

Baspinar N.

• Department of Biochemistry, Faculty of Veterinary Medicine, University of Selcuk, 42079, Konya, Turkey

autor

Hatipoglu F.

• Department of Pathology, University of Selcuk, 42079, Konya, Turkey

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