The interaction between paroxetine and some cytokines in the animal model of depression

• Autorzy: Manikowska K. , Mikolajczak P. L. , Bobkiewicz-Kozlowska T. , Modzelewska J.
• Języki publikacji: EN

Abstrakty

EN

Knowledge about the role of cytokines in the action antidepressant drugs is still insufficient. The aim of the this study was to evaluate the effect of paroxetine (PAR) on the levels of tumor necrosis factor alpha (TNFα), and interleukin-10 (IL-10) in the blood of rats in an experimental model of depression. Male Wistar rats were subjected to chronic mild stress (CMS) for 6 weeks. Following the development of anhedonia, the stressed and control rats (non-stressed animals) were treated with PAR (12.5 mg/kg b.w., p.o. 1× daily) for three weeks. On the last day of the experiment, an acute lipopolysaccharide (LPS, 100 µg/kg b.w., i.p.) was injected to PAR or vehicle-treated rats and TNFα and IL-10 levels were assayed using ELISA methods. In stressed animals the level of TNFα was found to be significantly higher compared to non-stressed animals. PAR resulted in significant decrease in TNFα level and simultaneously the increase of IL-10 in the stressed animals. In conclusion, PAR induced normalisation of the TNFα level increased by stress and LPS and elevation of IL-10 level in animal model of depression what confirms the hypothesis that level of cytokines can be modulated by antidepressant drugs.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.55-56

Twórcy

autor

Manikowska K.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

autor

Mikolajczak P. L.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

autor

Bobkiewicz-Kozlowska T.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

autor

Modzelewska J.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland