Different regions of the apical branch of CAI dendrites express specific forms of LTD in hippocampal slices in vitro

• Autorzy: Parvez S. , Ramachandran B. , Frey J.
• Języki publikacji: EN

Abstrakty

EN

Long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission are widespread phenomena expressed at many excitatory synapses in the mammalian brain. Because of its long duration, input specifi city and associative properties, LTP and LTD have been used as cellular models for memory. We wanted to investigate whether different locations on the apical dendritic branch could infl uence the induction of LTD and its related properties. Late-LTD could be induced in the apical CA1 dendrites by strong low-frequency stimulation (SLFS) pattern if the synapses were located distally, whereas, proximally located synapses were not able to maintain late-LTD. However, SLFS in both locations was able to trigger the synthesis of plasticity-related proteins, which could be evidenced by cross tagging experiments. In addition, we have investigated if hippocampal CA1-LTP prevents/occludes the establishment of LTD in the same synaptic input at specifi c time points after LTP-induction. We show induction of LTP occludes longer-lasting but not short-term LTD about 1 h after LTP-induction. However, after 4 h, i.e. after transformation of early- into late-LTP, also later forms of LTD can again be induced in the same synaptic input. Our results demonstrate that hippocampal neurons do not lose their capacity for the induction of longer forms of LTP or LTD after the establishment of late-LTP in the apical dendrites of hippocampal CA1- neurons.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.332

Twórcy

autor

Parvez S.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany

autor

Ramachandran B.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany

autor

Frey J.

• Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany