Effect of Mimosa pudica cured extract against high fructose diet induced type 2 diabetes in rats

• Autorzy: Sundaresan A. , Radhiga T.
• Języki publikacji: EN

Abstrakty

EN

The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.

Słowa kluczowe

EN

medicinal plant; Mimosa pudica; medicinal property; dyslipidemia; liver fat; lipid accumulation; accumulation; diabetes type 2; high-fructose diet; glucose intolerance; hyperinsulinemia; hyperglycemia; hypertriglyceridemia; plant extract

• Wydawca: -
• Czasopismo: International Letters of Natural Sciences
• Rocznik: 2015
• Tom: 39
• Opis fizyczny: p.1-9,fig.,ref.

Twórcy

autor

Sundaresan A.

• Assistant Professor, Department of Biotechnology, Sri Vinayaga College of Arts and Science, Ulundurpet - 606107, Tamilnadu, India

autor

Radhiga T.

• UGC-Post Doctoral Fellow, Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India

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Identyfikatory

DOI

10.18052/www.scipress.com/ILNS.39.1