Histological and immunohistochemical evaluation of epithelial and mesenchymal tumors of psittacines

• Autorzy: Erdogan Bamac O. , Arun S.S.
• Języki publikacji: EN

Abstrakty

EN

This study describes histological and immunohistochemical evaluation of 50 epithelial and mesenchymal tumors of psittacines that were found in the archives of the pathology departments of veterinary faculties at Utrecht University and Istanbul University Cerrahpasa. In each case, cellular morphological features, tumoral pattern and mitotic activity were evaluated histologically, and immunohistochemistry was performed by the streptavidin-biotin immunoperoxidase method using a panel of commercially available antibodies raised against pan-cytokeratin, vimentin, muscle-specific actin, desmin, smooth muscle actin and Factor VIII/von Willebrand Factor. The histological evaluation revealed that 30 epithelial tumors were squamous cell carcinoma (n: 20), renal adenocarcinoma (n: 3), basal cell carcinoma (n: 2), abdominal carcinoma (n: 2), uropygial gland carcinoma (n: 1), cloacal carcinoma (n: 1) and cholangiocarcinoma (n: 1). Out of the 50 tumors, 13 had a mesenchymal origin and were diagnosed as fibrosarcoma (n: 4), hemangioma (n: 3), hemangiosarcoma (n: 4) and leiomyosarcoma (n: 2). Histological diagnosis could not be made for 7 tumors, and they were evaluated as undifferentiated malignant tumors (UDMT). Two tumors diagnosed as fibrosarcoma and three tumors diagnosed as UDMT showed strong SMA staining and were re-diagnosed as leiomyosarcoma. In view of the IHC findings, two other UDMTs were re-diagnosed as fibrosarcoma and anaplastic carcinoma. Although only a limited number of antibodies were used in the control panel, they were useful in establishing a definite diagnosis in some cases.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2020
• Tom: 76
• Numer: 03
• Opis fizyczny: p.165-169,fig.,ref.

Twórcy

autor

Erdogan Bamac O.

• Faculty of Veterinary Medicine, Istanbul University Cerrahpasa, Istanbul, Turkey

autor

Arun S.S.

• Vetlab Veterinary Laboratory, Istanbul, Turkey

Bibliografia

• Bauck L.: Neoplasms. Diseases of Cage and Aviary Birds. Williams-Wilkins, Philadelphia 1996, 476-478.
• Bettini G., Morini M., Marcato P. S.: Gastrointestinal spindle cell tumours of the dog: histological and immunohistochemical study. J. Comp. Pathol. 2003, 129, 283-293.
• Blackmore D. K.: The clinical approach to tumors in cage birds-I. J. Small. Anim. Pract. 1966, 7, 217-223.
• Bonel J., Alberti T. S., Stumm G. K. F., Gamba C. O., Bandarra P.,Cassali G. D.: Leiomyosarcoma in a cockatiel. Cienc. Rural. 2019, 1-4.
• Cardoso J. F. R., Levy M. G. B.: Pathological and Immunohistochemical Diagnosis af an Intestinal Leiomyosarcoma in a Zebra Finch. Braz. J. Vet. Pathol. 2014, 7, 89-92.
• Latimer K. S.: Avian Medicine. Principles and Application. Wingers Publishing, Lake Worth 1994, p. 640-670.
• Murtaugh R. J., Ringler D. J., Petrak M. L.: Squamous cell carcinoma of the esophagus in an Amazon parrot. J. Am. Vet. Med. Assoc. 1986, 188, 872-873.
• Nakano Y., Une Y.: Hemangiosarcoma with Widespread Mestatasis that Originated on the Matatarsal Pad of a Java Sparrow (Padda oryzivora). J. Vet. Med. Sci. 2012, 74, 621-623.
• Pye G. W., Carpenter J. W., Goggin J. M., Bacmeister C.: Metastatic squamous cell carcinoma in a salmon-crested cockatoo (Cacatua moluccensis). J. Avian Med. Surg. 1999, 13, 192-200.
• Ramis A., Gibert X., Majo N., Grifols J.: Metastatic oral squamous cell carcinoma in a Montagu’s harrier (Circus pigargus). J. Vet. Diagn. Invest. 1999, 11, 191-194.
• Reavill D.: A review of psittacine squamous cell carcinomas submitted during 1998-2001. Proc. of Ann. Con. Eu. Assoc. Avian Veterinary 2003, p. 237-240.
• Reece R. L.: Observations on naturally occuring neoplasms in birds in the state of Victoria. Australia. Avian Pathol. 1992, 21, 3-32.
• Riddell C., Cribb P. H. E.: Fibrosarcoma in an African grey parrot (Psittacus erithacus). Avian Dis. 1982, 27, 549-555.
• Rossi G.: A poorly-differentiated hepatic haemangiosarcoma in an Amazona farinosa parrot. Avian Pathol. 1998, 27, 427-430.
• Schmidt R. E., Quesenberry K.: Avian Medicine and Surgery. W. B. Saunders, Philadelphia 1997, 234-237.
• Simova-Curd S., Huder J. B., Boeni J., Robert N., Hatt J. M.: Investigations on the diagnosis and retroviral aetiology of renal neoplasia in budgerigars (Melopsittacus undulatus). Avian Pathol. 2010, 39, 161-167.
• Simova-Curd S., Nitzl D., Mayer J., Hatt J. M.: Clinical approach to renal neoplasia in budgerigars (Melopsittacus undulatus). Small Anim. Pract. 2006, 47, 504-511.
• Tell L. A., Woods L., Mathews K. G.: Basal cell carcinoma in a blue-fronted Amazon parrot (Amazona aestiva). Avian Dis. 1997, 41, 755-759.
• Timurkaan N., Eroksuz H., Cevik A., Karabulut B.: Cutaneous leiomyosarcoma with osteoid metaplasia in a budgerigar (Melopsittacus undulatus): a case report. Vet. Med. Czech. 2016, 61, 533-537.
• Zamani-Ahmadmahmudi M., Nassiri S. M., Khaksar E., Solati A. A.: A rare case of cutaneous leiomyosarcoma in budgerigar (Melopsittacus undulatus). Arch. Razi. Inst. 2015, 70, 57-60.
• Zehnder A., Graham J., Reavill D. R., Mclaughlin A.: Current Therapy in Avian Medicine and Surgery. Elsevier, Missouri 2016, 107-141.
• Zehnder A. M., Swift L. A., Sundaram A., Speer B. L., Olsen G. P., Hawkins M. G., Paul-Murphy J.: Clinical features, treatment, and outcomes of cutaneous and oral squamous cell carcinoma in avian species. J. Am. Vet. Med. Assoc. 2018, 252, 309-315.

Identyfikatory

DOI

10.21521/mw.6377