Naltrexone reduces ethanol consumption and normalizes ghrelin peripheral blood levels in alcohol dependent rats

• Autorzy: Szulc M. , Kaminska E. , Mikolajczak P. L.
• Języki publikacji: EN

Abstrakty

EN

Naltrexone is an opioid receptor antagonist used in the management of alcohol dependence. There is a hypothesis that ghrelin, hungerstimulating peptide, could take part in the central effects of alcohol and also act as a peripheral marker of long-term ethanol consumption. The aim of this study was to assess the effect of naltrexone on ghrelin plasma level in the model of alcoholism. The study was performed using male Wistar alcohol preferring (PR) and nonpreferring (NP) rats. Naltrexone (0.1 mg/kg, i.p.), was administered to rats for 28 consecutive days. Peripheral blood was collected three times (preliminary, after preference period, and after naltrexone treatment) and the acetylated ghrelin and total ghrelin concentrations in plasma were measured using ELISA method. It was observed that chronic alcohol intake in PR animals led to decrease concentrations of both, active and total ghrelin in comparison to NP rats. After naltrexone administration the increase of active and total ghrelin levels were found in PR rats which corresponded with naltrexone lowering of alcohol consumption. Concluding, ghrelin could be of value as a possible indicator of antialcoholic activities of drugs shown by the lowering of alcohol intake.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.51

Twórcy

autor

Szulc M.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

autor

Kaminska E.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

autor

Mikolajczak P. L.

• Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
• Department of Pharmacology and Experimental Biology, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland