The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep

• Autorzy: Yildiz R. , Durna Corum D. , Corum O. , Ider M. , Atik O. , Ok O. , Uney K.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to investigate the cardiotoxic effect of the combination of tilmicosin and diclofenac sodium in sheep. Thirty-two sheep were used and were randomly divided into four equal groups as tilmicosin (T), diclofenac sodium (D), tilmicosin+diclofenac sodium (TD) and control (C) group. Group T received a single dose of tilmicosin, Group D was administered diclofenac sodium once a day for 3 days, and group TD was administered diclofenac and tilmicosin at the same doses as group T and D. Group C received NaCl in a similar way. The blood samples were taken before dosing and at 4th, 8th, 24th and 72nd hour post-dosing for measurement of cardiac markers such as H-FABP, cTn-I, CK-MB. H-FABP level of group TD was found to be significantly (p<0.05) higher than of group C at the 8th, 24th and 72nd hour and group D and T at the 72nd hour. cTn-I and CK-MB levels of group TD were found significantly (p<0.05) higher compared with other groups. In conclusion, the combined use of tilmicosin and diclofenac in sheep causes an increase in cardiac biomarkers and it can be stated that this combination of drugs may cause cardiac damage.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2023
• Tom: 26
• Numer: 1
• Opis fizyczny: p.5-12,fig.,ref.

Twórcy

autor

Yildiz R.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Burdur Mehmet Akif Ersoy, 15030, Burdur, Turkey

autor

Durna Corum D.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, 31060, Hatay, Turkey

autor

Corum O.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, 31060, Hatay, Turkey

autor

Ider M.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, 42100, Konya, Turkey

autor

Atik O.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, 03030, Afyonkarahisar, Turkey

autor

Ok O.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, 42100, Konya, Turkey

autor

Uney K.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42100, Konya, Turkey

Identyfikatory

DOI

10.24425/pjvs.2023.145001