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2013 | 69 | 02 |

Tytuł artykułu

Patogenne działanie ochratoksyny A

Warianty tytułu

EN
Pathogenic effects of ochratoxin A

Języki publikacji

PL

Abstrakty

EN
Some fungi in specific environmental conditions may produce mycotoxins, especially ochratoxin A. It is produced mainly by Aspergillus ochraceus, A. carbonarium and Penicillium verrucosum, and commonly occurs in foodstuff and feed products. Ochratoxin A is metabolized in the organism in the liver and excreted mainly by the urinary way as well as with bile and feces. After absorption by the organism, ochratoxin binds blood serum proteins, which retards its direct toxic action but elongates its half time. Ochratoxin A demonstrates a multifactorial pathological influence, especially nephrotoxic, hepatotoxic, immunotoxic and carcinogenic. By damaging the mechanism responsible for the organic anion transport in epithelial cells brush border of the proximal convoluted tubules it causes kidney dysfunction. The disturbance of protein synthesis negatively influences mitotic divisions and differentiation of rapidly dividing cells in the immunologic system and mucus membrane of the digestive tract. Ochratoxin causes periodical inhibition of osteoblast proliferation, collagen fibers synthesis and bone mineralization. In humans ochratoxin is recognized as the main etiologic factor of Balkan Endemic Nephropathy, while in pigs it causes a disease named mycotoxicose nephropathy.

Wydawca

-

Rocznik

Tom

69

Numer

02

Opis fizyczny

s.91-95,tab.,bibliogr.

Twórcy

autor
  • Pracownia Ekologii i Chorób Zwierząt Łownych, Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, ul.Norwida 31, 50-375 Wrocław
autor
  • Pracownia Ekologii i Chorób Zwierząt Łownych, Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, ul.Norwida 31, 50-375 Wrocław
autor
  • Zakład Patomorfologii i Weterynarii Sądowej, Katedra Patologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, ul.Norwida 31, 50-375 Wrocław

Bibliografia

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  • 2.Abdelraheim M. A., Meki A. A., Hussein A.: Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp. Bioch. Physiol. 2001, 130, 305-313.
  • 3.Barisic K., Petric J., Rumora L., Ceplak I., Grubisic T. Z.: Expression of Hsp 70 in kidney cells exposed to ochratoxin A. Arch. Toxicol. 2002, 76, 218-226.
  • 4.Baudrimont A. M., Betbeder., Creppy E. E.: Reduction of the ochratoxin A induced cytotoxicity in vero cells by aspartame. Arch. Toxicol. 1998, 71, 390-398.
  • 5.Belmadani A., Tramu G.: Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain. Arch. Toxicol. 1998, 72, 656-662.
  • 6.Biro K., Barna-Vetra I., Pecsi T., Szabo E., Winkler G., Gremmels F., Solti J.: Evaluation of spermatological parameters in ochratoxin A - challenged boars. Theriogenology 2003, 60, 199-207.
  • 7.Blank R., Rolfs J. P., Sudekum K. H., Frochlich A. A., Marquardt R. R., Wolfram S.: Effects of chronic ingestion of ochratoxin A on blood vessels and excretion of the mycotoxin in sheep. J. Agric. Food. Chem. 2003, 51, 6899-6905.
  • 8.Brochard G., Le Bacle C.: Mycotoxines en milieu du travail. Inst. Nation. Rech. Scient. 2009, 119, 299-323.
  • 9.Corrier D. E.: Mycotoxicosis: mechanism of immunosupression. Vet. Immunol. Immunopathol. 1991, 30, 73-87.
  • 10.Creppy E. E., Baudrimont I., Anne M.: How aspartame prevents the toxicity of ochratoxine A. J. Toxicol. Sci. 1998, 23, 165-172.
  • 11.Creppy E. E., Chaker K.: The mycotoxin ochratoxin A is a substrat for phenylalanine hydroxylase in isolated rat hepatocytes and in vivo. Arch. Toxicol. 1990, 64, 279-284.
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  • 15.Gekle M., Miedenberger S., Freudinger R., Silbernagl S.: The mycotoxin ochratoxin A impairs protein uptake in cells derived from the proximal tubule of the kidney (opossum kidney cells). J. Pharmacol. Exp. Ther. 1994, 271, 1-6.
  • 16.Girish C. K., Smith T. K.: Effects of feeding blends of grains naturally contaminated with fuzarium mycotoxins on small intestinal morphology of turkeys. Poult. Sci. 2008, 87, 1075-1082.
  • 17.Goliński P.: Ochratoksyna A w organizmie ludzkim jako wynik zanieczyszczenia żywności i pasz. Zesz. Nauk. AR Poznań. 1987, 1-62.
  • 18.Haubeck H. D., Lorkowski G., Kolsch E., Roschethaler R.: Immunosupression by ochratoxin A and its prevention by phenylalanine. Appl. Environ. Microbiol. 1981, 41, 1040-1042.
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  • 20.Huff W. E., Wyatt R. D., Tucker T. L., Hamilton P. B.: Ochratoxicosis in the broiler chicken. Poult. Sci. 1974, 53, 1585-1591.
  • 21.Koynarski V., Stoev S. D., Grozeva N., Mirtcheva T.: Experimental coccidiosis provoked by Eimeria adenoids in turkey poults given ochratoxin A. Vet. Arhiv 2007, 77, 113-128.
  • 22.Kozaczyński W.: Experimental ochratoxicosis A in chickens immunological studies. Bull. Vet. Inst. Pulawy 1994, 38, 1-8.
  • 23.Kubena L. F., Harvey W. E., Corrier D. E.: Influence of ochratoxin A and T-2 toxin singly in combination on broilers chickens. Poult. Sci. 1989, 68, 867-872.
  • 24.Li S., Marquardt R. R., Frohlich A. A., Vitti G., Crow G.: Pharmacokinetics of ochratoxin A and it's metabolites in rats. Toxicol. Appl. Pharmacol. 1997, 145, 82-90.
  • 25.Marquardt R., Frochlich A.: A review of recent advances in understanding ochratoxicosis. J. Anim. Sci. 1992, 70, 3966-3988.
  • 26.Nedeljković J., Sinovec S., Sinovec Z.: Patomorphological alterations and reperatory processes in the kidneys of broilers treated with ochratoxin A. Acta Vet. Beograd 2001, 51, 333-342.
  • 27.Nedeljković J., Trailovic J. S.: Blood serum protein of broilers exposed to prolonged treatment with a low dose of ochratoxin A. Acta. Vet. Beograd 2000, 50, 13-22.
  • 28.Niemiec J.: Wpływ ochratoksyny A na przebieg wzrostu, produkcję i reprodukcję kur. Rozprawy Naukowe i Monografie. Wyd. SGGW, Warszawa 1991, 135.
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  • 30.Rouibah K.: Morfologiczne i czynnościowe wykładniki zatrucia kurcząt ochratoksyną A. Praca dokt. Wydz. Med. Wet. UP, Wroc³aw 2011.
  • 31.Sauvant C., Silbernagl S., Gekle M.: Exposure to ochratoxin A impairs organic anion transport in proximal tubule derived opossum kidney cells. J. Pharm. Exp. Therap.1998, 287, 13-20.
  • 32.Schaff G. J., Niejmeijer S. M.: The role of oxidative stress in the ochratoxin A mediated toxicity in proximal tubular cells. Biochim. Biophys. Acta (Mol. Basis Dis.) 2002, 1588, 149-158.
  • 33.Stoev S., Anguelov G., Pavlov D.: Some antidotes and paraclinical investigations in experimental intoxication with ochratoxicosis and penicilic acid in chicks. Vet. Arhiv 1999, 69, 179-189.
  • 34.Stoev S. D.: The role of ochratoxin A as a possible cause of BEN and its risk evaluation. Vet. Human Toxicol. 1998, 40, 352-360.
  • 35.Stoev S. D., Gondaszeva D., Mirtcheva T., Mantle P. G.: Susceptibility to secondary bacterial infections in growing pigs as an early response in ochratoxicosis. Exp. Toxicol. Pathol. 2000, 52, 287-296.
  • 36.Stoev S. D., Paskalev M.: Experimental one year ochratoxin A toxicosis in pigs. Exp. Toxicol. Pathol. 2002, 53, 481-487.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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