Antimicrobial properties of substituted Quino[3,2-b]benzo[1,4]thiazines

• Autorzy: Czarny A. , Jelen M. , Zimecki M. , Pluta K. , Morak-Mlodawska B. , Artym J. , Kocieba M.
• Języki publikacji: EN

Abstrakty

EN

Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF α) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl-2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2014
• Tom: 63
• Numer: 3
• Opis fizyczny: p.335-339,fig.,ref.

Twórcy

autor

Czarny A.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences Department of Experimental Therapy, R.Weigla 12, 53-114 Wroclaw, Poland

autor

Jelen M.

• Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland

autor

Zimecki M.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences Department of Experimental Therapy, R.Weigla 12, 53-114 Wroclaw, Poland

autor

Pluta K.

• Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland

autor

Morak-Mlodawska B.

• Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland

autor

Artym J.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences Department of Experimental Therapy, R.Weigla 12, 53-114 Wroclaw, Poland

autor

Kocieba M.

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences Department of Experimental Therapy, R.Weigla 12, 53-114 Wroclaw, Poland

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