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2017 | 20 | 2 |

Tytuł artykułu

Cytokine profiles of dendritic cells (DCs) during infection with bovine leukaemia virus (BLV)

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
BLV is an agent of enzootic bovine leukaemia (EBL), an infectious disease affecting cattle worldwide. BLV infection has been associated with immune system disorders and discrepancies in the cytokine network. The significance of dendritic cells in the pathogenesis of BLV infection is largely unknown, but considering their fundamental role in immune response it may be crucial. Dcs precursors were isolated with the use of immunomagnetic beads from BLV-infected and BLV-free cows. From these precursors cultures of monocyte derived dendritic cells (MoDCs) were generated with the use of a cytokine cocktail (IL-4 and GM-CSF). Additionally, parallel DCs from BLV-negative animals were infected in vitro. The level of cytokines: IL-6, IL-10, IL-12(p40), IL-12(p70) was determined in DC cultures: infected in vitro, originating from naturally infected cattle and BLV-free cattle. The investigation showed significant changes in almost all analyzed populations of BLV-infected Dcs. Cytokine profiles of blood MoDCs indicated activation of these groups during infection. In the case of spleen MoDCs and lymph node MoDCs a decrease in production of IL-12(p40) and IL-12(p70) in favour of IL-6 and IL-10 was noted, suggesting promotion of BLV infection development.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

20

Numer

2

Opis fizyczny

p.221-231,fig.,ref.

Twórcy

autor
  • Department of Biochemistry, National Veterinary Research Institute, al. Partyzantow 57, 24-100 Pulawy, Poland
autor
  • Department of Biochemistry, National Veterinary Research Institute, al. Partyzantow 57, 24-100 Pulawy, Poland
autor
  • Department of Clinical Genetics, Medical University, Radziwillowska 11, 20-080 Lublin, Poland

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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