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2017 | 73 | 02 |
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Odzwierzęce szczepy Staphylococcus aureus oporne na metycylinę (LA-MRSA) - obecny stan wiedzy

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Livestock-associated strains of methicillin resistant Staphylococcus aureus (LA-MRSA) - the current state of knowledge
Języki publikacji
A methicillin-resistant Staphylococcus aureus (MRSA) referred to as livestock-associated (LA-MRSA) has recently emerged in farm animals, particularly in pigs. Strains of this MRSA variant from Europe and North America mostly belong to clonal complex (CC) 398. Generally LA-MRSA cause asymptomatic colonization among pigs, but also in veal calves, broiler chickens, turkeys, and horses. People in contact with livestock animals are at high risk of asymptomatic colonization or infection with these bacteria. In previous years, the impact of LA-MRSA on human health was considered small. However, LA-MRSA has become more prevalent among people without direct livestock contact, especially in areas with a high density of pig production. As a result of horizontal gene transfer S. aureus CC398 strains are constantly evolving. The adaptive power of S. aureus to new hosts and acquisition of resistance to antibiotics may cause the emergence of new, more virulent clones. LA-MRSA has evolved from human-adapted methicillin-susceptible S. aureus CC398, which was proved by comparative genome analysis. The adaptation to livestock was associated with several genetic changes. The most worrying aspect of MRSA CC398 seems to be its ability to spread to humans. For this reason, continuous surveillance of further genetic changes is recommended.
Opis fizyczny
  • Zakład Mikrobiologii, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego, ul. Ciszewskiego 8, 02-786 Warszawa
  • Katedra Higieny Żywności i Ochrony Zdrowia Publicznego, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego, ul. Nowoursynowska 159, 02-776 Warszawa
  • Alen S. van, Ballhausen B., Peters G., Friedrich A. W., Mellmann A., Köck R., Becker K.: In the centre of an epidemic: Fifteen years of LA-MRSA CC398 at the University Hospital Münster. Vet. Microbiol. 2016, S0378-1135 (in press). doi: 10.1016/j.vetmic.2016.01.021.
  • Analysis of the base-line survey on the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in holdings with breeding pigs, in the EU. Part A: MRSA prevalence estimates, EFSA Journal 2009, 7, 1-82. doi:10.2903/j.efsa.2009.1376.
  • Argudin M. A., Fetsch A., Tenhagen B. A., Hammerl J. A., Hertwig S., Kowall J., Rodicio M. R., Käsbohrer A., Helmuth R., Schroeter A., Mendoza M. C., Bräunig J., Appel B., Guerra B.: High heterogeneity within methicillin-resistant Staphylococcus aureus ST398 isolates, defined by Cfr9I macrorestriction-pulsed-field gel electrophoresis profiles and spa and SCCmec types. Appl. Environ. Microbiol. 2010, 76, 652-658.
  • Armand-Lefevre L., Ruimy R., Andremont A.: Clonal comparison of Staphylococcus aureus isolates from healthy pig farmers, human controls, and pigs. Emerg. Infect. Dis. 2005, 11, 711-714.
  • Aspiroz C., Lozano C., Gilaberte Y., Zarazaga M., Aldea M. J., Torres C.: Molecular characterisation of methicillin resistant Staphylococcus aureus strains ST398 in patients with skin infections and their relatives. Enferm. Infecc. Microbiol. Clin. 2012, 30, 18-21.
  • Ballhausen B., Jung P., Kriegeskorte A., Makgotlho P. E., Ruffing U., von Müller L., Köck R., Peters G., Herrmann M., Ziebuhr W., Becker K., Bischoff M.: LA-MRSA CC398 differ from classical community acquired-MRSA and hospital acquired-MRSA lineages: functional analysis of infection and colonization processes. Int. J. Med. Microbiol. 2014, 304, 777-786.
  • Banaszkiewicz T., Krukowski H.: Chorobotwórczość MRSA dla ludzi i zwierząt. Med. Weter. 2014, 70, 151-156.
  • Boer E. de, Zwartkruis-Nahuis J. T., Wit B., Huijsdens X. W., de Neeling A. J., Bosch T., van Oosteromb R. A., Vila A., Heuvelink A. E.: Prevalence of methicillin-resistant Staphylococcus aureus in meat. Int. J. Food Microbiol. 2009, 134, 52-56.
  • Bosch T., Verkade E., van Luit M., Landman F., Kluytmans J., Schouls L. M.: Transmission and persistence of livestock-associated methicillin-resistant Staphylococcus aureus among veterinarians and their household members. Appl. Environ. Microbiol. 2015, 81, 124-129.
  • Brunel A. S., Bañuls A. L., Marchandin H., Bouzinbi N., Morquin D., Jumas-Bilak E., Corne P.: Methicillin-sensitive Staphylococcus aureus CC398 in intensive care unit, France. Emerg. Infect. Dis. 2014, 20, 1511-1515.
  • Cavaco L. M., Hasman H., Aarestrup F. M.: Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance. Vet. Microbiol. 2011, 150, 344-348.
  • Cleef B. A. van, Broens E. M., Voss A., Huijsdens X. W., Züchner L., Van Benthem B. H., Kluytmans J. A., Mulders M. N., Van De Giessen A. W.: High prevalence of nasal MRSA carriage in slaughterhouse workers in contact with live pigs in The Netherlands. Epidemiol. Infect. 2010, 138, 756-763.
  • Cleef B. A. van, Graveland H., Haenen A. P., van de Giessen A. W., Heederik D., Wagenaar J. A., Kluytmans J. A.: Persistence of livestock-associated methicillin-resistant Staphylococcus aureus in field workers after short-term occupational exposure to pigs and veal calves. J. Clin. Microbiol. 2011, 49, 1030-1033.
  • Cleef B. A. van, van Benthem B. H., Verkade E. J., van Rijen M. M., Kluytmansvan den Bergh M. F., Graveland H., Bosch T., Verstappen K. M., Wagenaar J. A., Heederik D., Kluytmans J. A.: 2016 Health and health-related quality of life in pig farmers carrying livestock-associated methicillin-resistant Staphylococcus aureus. Epidemiol. Infect. 2016, 6, 1-10.
  • Cleef B. A. van, van Benthem B. H., Verkade E. J., van Rijen M., Kluytmansvan den Bergh M. F., Schouls L. M., Duim B., Wagenaar J. A., Graveland H., Bos M. E., Heederik D., Kluytmans J. A.: Dynamics of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus carriage in pig farmers: a prospective cohort study. Clin. Microbiol. Infect. 2014, 20, O764-O771.
  • Cuny C., Abdelbary M., Layer F., Werner G., Witte W.: Prevalence of the immune evasion gene cluster in Staphylococcus aureus CC398. Vet. Microbiol. 2015, 177, 219-223.
  • Cuny C., Friedrich A., Kozytska S., Layer F., Nübel U., Ohlsen K., Strommenger B., Walther B., Wieler L., Witte W.: Emergence of MRSA in different animal species. Int. J. Med. Microbiol. 2010, 300, 109-117.
  • Cuny C., Köck R., Witte W.: Livestock associated MRSA (LA-MRSA) and its relevance for humans in Germany. Int. J. Med. Microbiol. 2013, 303, 331-337.
  • Cuny C., Layer F., Köck R., Werner G., Witte W.: Methicillin susceptible Staphylococcus aureus (MSSA) of clonal complex CC398, t571 from infections in humans are still rare in Germany. PLoS One. 2013. doi: 10.1371/journal.pone.0083165.
  • Cuny C., Nathaus R., Layer F., Strommenger B., Altmann D., Witte W.: Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs. PLoS One. 2009. doi: 10.1371/journal.pone.0006800.
  • Gilbert M. J., Bos M. E., Duim B., Urlings B. A., Heres L., Wagenaar J. A., Heederik D. J.: Livestock-associated MRSA ST398 carriage in pig slaughterhouse workers related to quantitative environmental exposure. Occup. Environ. Med. 2012, 69, 472-478.
  • Graveland H., Duim B., van Duijkeren E., Heederik D., Wagenaar J. A.: Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans. Int. J. Med. Microbiol. 2011, 301, 630-634.
  • Graveland H., Wagenaar J. A., Bergs K., Heesterbeek H., Heederik D.: Persistence of livestock associated MRSA CC398 in humans is dependent on intensity of animal contact. PLoS One. 2011, 6, e16830.
  • Hetem D. J., Derde L. P., Empel J., Mroczkowska A., Orczykowska-Kotyna M., Kozińska A., Hryniewicz W., Goossens H., Bonten M. J.: MOSAR WP3 Study Group. Molecular epidemiology of MRSA in 13 ICUs from eight European countries. J. Antimicrob. Chemother. 2016, 71, 45-52.
  • Jung P., Abdelbary M. M., Kraushaar B., Fetsch A., Geisel J., Herrmann M., Witte W., Cuny C., Bischoff M.: Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398. Vet. Microbiol. 2016 (in press). doi: 10.1016/j.vetmic.2016.02.015.
  • Karakulska J., Nawrotek P., Fijałkowski K.: Leukocydyna Panton-Valentine – aspekty znane i nieznane. Post. Mikobiol. 2015, 54, 250-257.
  • Kottler S., Middleton J. R., Perry J., Weese J. S., Cohn L. A.: Prevalence of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus carriage in three populations. J. Vet. Intern. Med. 2010, 24, 132-139.
  • Koyama H., Sanui M., Saga T., Harada S., Ishii Y., Tateda K., Lefor A. K.: A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan. J. Infect. Chemother. 2015, 21, 541-543.
  • Köck R., Loth B., Köksal M., Schulte-Wülwer J., Harlizius J., Friedrich A. W.: Persistence of nasal colonization with livestock-associated methicillin-resistant Staphylococcus aureus in pig farmers after holidays from pig exposure. Appl. Environ. Microbiol. 2012, 78, 4046-4047.
  • Krupa P., Bystroń J., Podkowik M., Empel J., Mroczkowska A., Bania J.: Population structure and oxacillin resistance of Staphylococcus aureus from pigs and pork meat in South-West of Poland. Biomed. Res. Int. 2015. doi: 10.1155/2015/141475.
  • Larsen J., Petersen A., Sørum M., Stegger M., van Alphen L., Valentiner-Branth P., Knudsen L. K., Larsen L. S., Feingold B., Price L. B., Andersen P. S., Larsen A. R., Skov R. L.: Methicillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011. Euro. Surveill. 2015. doi: 10.2807/1560-7917.
  • Layer F., Cuny C., Strommenger B., Werner G., Witte W.: Current data and trends on methicillin-resistant Staphylococcus aureus (MRSA). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012. doi: 10.1007/s00103-012-1560-x.
  • Lekkerkerk W. S., van Wamel W. J., Snijders S. V., Willems R. J., van Duijkeren E., Broens E. M., Wagenaar J. A., Lindsay J. A., Vos M. C.: What is the origin of livestock-associated methicillin-resistant Staphylococcus aureus clonal complex 398 isolates from humans without livestock contact? An Epidemiological and Genetic Analysis. J. Clin. Microbiol. 2015, 53, 1836-1841.
  • Lindsay J. A.: Genomic variation and evolution of Staphylococcus aureus. Int. J. Med. Microbiol. 2010, 300, 98-103.
  • Loo I. van, Huijsdens X., Tiemersma E., de Neeling A., van de Sande-Bruinsma N., Beaujean D., Voss A., Kluytmans J.: Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg. Infect. Dis. 2007, 13, 1834-1839.
  • Mediavilla J. R., Chen L., Mathema B., Kreiswirth B. N.: Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) Curr. Opin. Microbiol. 2012, 15, 588-595.
  • Mossong J., Gelhausen E., Decruyenaere F., Devaux A., Perrin M., Even J., Heisbourg E.: Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg, 2010. Epidemiol. Infect. 2013, 141, 1199-1206.
  • Normanno G., Dambrosio A., Lorusso V., Samoilis G., Di Taranto P., Parisi A.: Methicillin-resistant Staphylococcus aureus (MRSA) in slaughtered pigs and abattoir workers in Italy. Food Microbiol. 2015, 51, 51-56.
  • Porphyre T., Giotis E. S., Lloyd D. H., Stärk K. D.: A metapopulation model to assess the capacity of spread of methicillin-resistant Staphylococcus aureus ST398 in humans. PLoS One. 2012. doi: 10.1371/journal.pone.0047504.
  • Rasschaert G., Vanderhaeghen W., Dewaele I., Janez N., Huijsdens X., Butaye P., Heyndrickx M.: Comparison of fingerprinting methods for typing methicillin-resistant Staphylococcus aureus sequence type 398. J. Clin. Microbiol. 2009, 47, 3313-3322.
  • Richter A., Sting R., Popp C., Rau J., Tenhagen B. A., Guerra B., Hafez H. M., Fetsch A.: Prevalence of types of methicillin-resistant Staphylococcus aureus in turkey flocks and personnel attending the animals. Epidemiol. Infect. 2012, 140, 2223-2232.
  • Rijen M. M. van, Bosch T., Verkade E. J., Schouls L., Kluytmans J. A.: CAM Study Group. Livestock-associated MRSA carriage in patients without direct contact with livestock. PLoS One. 2014. doi: 10.1371/journal.pone.0100294.
  • Schulz J., Friese A., Klees S., Tenhagen B. A., Fetsch A., Rösler U., Hartung J.: Longitudinal study of the contamination of air and of soil surfaces in the vicinity of pig barns by livestock-associated methicillin-resistant Staphylococcus aureus. Appl. Environ. Microbiol. 2012, 78, 5666-5671.
  • Smith T. C., Wardyn S. E.: Human Infections with Staphylococcus aureus CC398. Curr. Environ. Health Rep. 2015, 2, 41-51.
  • Stefani S., Chung D. R., Lindsay J. A., Friedrich A. W., Kearns A. M., Westh H., Mackenzie F. M.: Methicillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods. Int. J Antimicrob. Agents 2012, 39, 273-282.
  • Stegger M., Lindsay J. A., Sørum M., Gould K. A., Skov R.: Genetic diversity in CC398 methicillin-resistant Staphylococcus aureus isolates of different geographical origin. Clin. Microbiol. Infect. 2010, 16, 1017-1019.
  • Stegger M., Liu C. M., Larsen J., Soldanova K., Aziz M., Contente-Cuomo T., Petersen A., Vandendriessche S., Jiménez J. N., Mammina C., van Belkum A., Salmenlinna S., Laurent F., Skov R. L., Larsen A. R., Andersen P. S., Price L. B.: Rapid differentiation between livestock-associated and livestock-independent Staphylococcus aureus CC398 clades. PLoS One. 2013. doi: 10.1371/journal.pone.0079645.
  • Uhlemann A. C., Porcella S. F., Trivedi S., Sullivan S. B., Hafer C., Kennedy A. D., Barbian K. D., McCarthy A. J., Street C., Hirschberg D. L., Lipkin W. I., Lindsay J. A., DeLeo F. R., Lowy F. D.: Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties. MBio. 2012. doi: 10.1128/mBio.00027-12.
  • Valentin-Domelier A. S., Girard M., Bertrand X., Violette J., François P., Donnio P. Y., Talon D., Quentin R., Schrenzel J., van der Mee-Marquet N.: Bloodstream Infection Study Group of the Réseau des Hygiénistes du Centre (RHC). Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone? PLoS One. 2011. doi: 10.1371/journal.pone.0028369.
  • Vandendriessche S., Kadlec K., Schwarz S., Denis O.: Methicillin-susceptible Staphylococcus aureus ST398-t571 harbouring the macrolide-lincosamide-streptogramin B resistance gene erm(T) in Belgian hospitals. J. Antimicrob. Chemother. 2011, 66, 2455-2459.
  • Vandendriessche S., Vanderhaeghen W., Soares F. V., Hallin M., Catry B., Hermans K., Butaye P., Haesebrouck F., Struelens M. J., Denis O.: Prevalence, risk factors and genetic diversity of methicillin-resistant Staphylococcus aureus carried by humans and animals across livestock production sectors. J. Antimicrob. Chemother. 2013, 68, 1510-1516.
  • Verkade E., Kluytmans J.: Livestock-associated Staphylococcus aureus CC398: animal reservoirs and human infections. Infect. Genet. Evol. 2014, 21, 523-530.
  • Voss A., Loeffen F., Bakker J., Klaassen C., Wulf M.: Methicillin resistant Staphylococcus aureus in pig farming. Emerg. Infect. Dis. 2005, 11, 1965-1966.
  • Waldron D. E., Lindsay J. A.: Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. J. Bacteriol. 2006, 188, 5578-5585.
  • Yu F., Chen Z., Liu C., Zhang X., Lin X., Chi S., Zhou T., Chen Z., Chen X.: Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin. Microbiol. Infect. 2008, 14, 381-384.
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