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2015 | 59 | 2 |

Tytuł artykułu

Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommended.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

59

Numer

2

Opis fizyczny

p.247-253,fig.,ref.

Twórcy

  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
  • Division of Pathomorphology and Veterinary Forensics, Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland

Bibliografia

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  • 2. Amorim R.L., Pinczowski P., Neto R.T., Rahal S.C.: Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours. Vet Comp Oncol 2010, 8, 23-27.
  • 3. Baram D., Vaday G.G., Salamon P., Drucker I., Hershkoviz R., Mekori Y.A.: Human mast cells release metalloproteinase-9 on contact with activated T-cells: juxtacrine regulation by TNF-αl. J Immunol 2001, 167, 4009-4016.
  • 4. Bossi P., Viale G., Lee A.K., Alfano R., Coggi G., Bosari S.: Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 1995, 55, 5049-5053.
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  • 6. Charpin C., Dales J.P., Garcia S., Carpentier S., Djemli A., Andrac L., Lavaut M.N., Allasia C., Bonnier P.: Tumor neoangiogenesis by CD31 and CD 105 expression evaluation in breast carcinoma tissue microarrays. Clin Cancer Res 2004, 10, 5815-5819.
  • 7. Ciaputa R., Kandefer-Gola M., Nowak M., Madej J.A.: Prevalence of tumours in domestic animals in the Lower Silesia (Poland) in 2009-2011. Bull Vet Inst Pulawv 2013, 57, 53-59.
  • 8. Crivellato E., Nico B., Ribatti D.: Mast cells and tumour angiogenesis: New insight from experimental carcinogenesis. Cancer Lett 2008, 269, 1-6.
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  • 21. Rebuzzi L., Willmann M., Sonneck K., Gleixner K.V., Florian S., Kondo R., Mayerhofer M., Vales A., Gruze A., Piekl W.F., Thalhammer J.G., Valent P.: Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Fit-1 and KDR in canine mastocytoma cells. Vet Immunol Immunopathol 2007, 115, 320-33.
  • 22. Sagawa K., Swaim W., Zhang J., Unsworth E., Siraganian R.P.: Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31 ). J Biol Chem 1997, 272, 13412-13418.
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  • 24. Shettar M., Rao S., Byregowda S.M., Sathyanarayana M.L., Purushttam K.M., Ramachandra S.G., Suryanarayana V.V.S., Shridhar N.B.: Immunohistochemical and quantitative real time PCR expression of vascular endothelial growth factor (VEGF) in canine mammary tumours. J Cell Tissue Res 2012, 12, 3133-3139.
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  • 28. Wang D., Stockard C.R., Harkins L., Lott P., Salih C., Yuan K, Buchsbaum D., Hashim A., Zayzafoon M., Hardy R.W., Hameed O., Grizzle W., Siegal G.P.: Immunohistochemistry in the evaluation of neovascularization in tumor xenografts. Biotech Histochem 2008, 83, 179-189.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-21d37935-bf2f-468e-8371-43769c663683
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