Participation of salsolinol in the regulation of the secretory activity of the pituitary gland in shep during lactation

• Autorzy: Misztal T. , Hasiec M. , Gorski K. , Marciniak E. , Romanowicz K.
• Języki publikacji: EN

Abstrakty

EN

Salsolinol is an endogenous derivative of dopamine (DA), previously known for its involvement in the progression of a disease characterized by dysfunctional dopaminergic neurons. In the last decade, more attention has been focused on the possible physiological role of salsolinol as a neuromodulator within the central nervous system. This DA-originated compound was found to be present in the pituitary gland, as well as in median eminence (ME) extracts and hypothalamic perfusates of rats and ruminants. Salsolinol is currently believed to be one of the hypothalamic factors stimulating both the synthesis and release of prolactin, especially during lactation. The stimulus that releases salsolinol during lactation is sucking. The high concentration of salsolinol in the hypothalamus and ME of lactating sheep suggests a role for this compound in mechanisms regulating other processes in which involvement of DA has been found. Studies using exogenous salsolinol or its antagonistic analogue (1-MeDIQ) conducted on lactating sheep showed that salsolinol also participated in the regulation of oxytocin secretion. It upregulated both oxytocin gene expression in the supraoptic and paraventricular nuclei and the content of this hormone in the posterior pituitary and stimulated its release into the circulation. Moreover, salsolinol infused into the third ventricle (IIIv) of the brain reduced the isolation stress-induced elevation of plasma ACTH and cortisol concentrations. Therefore, salsolinol may be considered to be one of the factors responsible for the adaptive inhibition of the HPA axis during lactation. Recent reports indicate that salsolinol may modulate (induce or inhibit) the activity of the GnRH/LH axis, depending on the site of administration (IIIv or ME). Further investigations are necessary to understand the molecular action of salsolinol and to elucidate the mechanism controlling the corticotropic and gonadotropic axes in sheep during lactation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S25

Twórcy

autor

Misztal T.

• Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland

autor

Hasiec M.

• Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland

autor

Gorski K.

• Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland

autor

Marciniak E.

• Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland

autor

Romanowicz K.

• Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland