Solid pituitary adenoma in Eker rats subjected to ketogenic diet

• Autorzy: Liskiewicz A. , Gendosz D. , Jedrzejowska-Szypulka H. , Lewin-Kowalik J.
• Języki publikacji: EN

Abstrakty

EN

Tuberous sclerosis (TS) is a genetic disease causing non-malignant tumors growth in the brain (e.g. pituitary adenoma) and in other organs. Ketogenic diet is already used in TS patients in treatment of epilepsy. However the mechanism of its influence on tumor growth is still not clear. The Eker rat is a useful model of TS: it has a spontaneous germ line mutation of the TSC2 gene what predisposed them to multiple tumors. In Eker rats, pituitary adenomas are common, occurring in 58% of adults (more than 18-months-old). Methods: Forty six 8-month-old Eker rats (males and females) were used. Twenty six (experimental group) have been maintained on high fat, low carbohydrate ketogenic diet for 6 months, while 20 (control group) received a standard rodent diet. At the age of 14 months rats were sacrificed. Anteroposterior, vertical, and transverse diameters of the found pituitary adenomas were measured. Size of tumors was calculated by using the formula for volume of the ellipsoid. Results: 8% animals from experimental group and 20% from control group have developed pituitary adenomas. Mean tumor volume in experimental group was 143 mm2 vs. 217 mm2 in control animals. Conclusion: Eker rats fed with ketogenic diet develops solid pituitary adenoma in 14 months of age. Incidence of these pituitary tumors in Eker rats fed with ketogenic diet (8%) was lower when compared with rats from control group (20%).

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.54-55

Twórcy

autor

Liskiewicz A.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Gendosz D.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Jedrzejowska-Szypulka H.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland

autor

Lewin-Kowalik J.

• Department of Physiology, School of Medicine, Medical University of Silesia, Katowice, Poland