Modeling social communication deficits in mouse models of autism

• Autorzy: Scattoni M.L.
• Języki publikacji: EN

Abstrakty

EN

Male and female mice emit ultrasonic vocalizations during infancy when pups are separated from mother and littermates, as well as at adulthood in different experimental/social contexts. Mouse ultrasonic vocalizations had become now a popular assay for behavioral phenotyping throughout the life-span of models of autism since this response represents the best option to detect deficits within the social communication domain in the mouse species. In the present talk, I will describe the available methods to elicit and record mouse ultrasonic vocalizations in different social contexts and at different ages and behavioral data collected on Autism animal models in these paradigms/contexts. Thanks to the progresses of computer technology, researchers can now perform detailed analyses of the vocal repertoire (classifying ultrasonic vocalizations into different categories). Recently, these analyses have revealed unusual vocal patterns in selected mouse lines. This innovative approach allows detecting also qualitative alterations in the social communication repertoire usually not identified with the standard analysis of emission rate. Future studies should be aimed at performing quantitative and qualitative analyses of vocalization patterns also in preclinical studies evaluating potential treatments in validated autism mouse models.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.351-352

Twórcy

autor

Scattoni M.L.

• Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy