A case of ectopic scrotum in a dog with Tyr236His substitutionin epidermal growth factor receptors

• Autorzy: Ruszczak A. , Jurka P. , Kacprzak K. , Watroba M. , Parada R. , Sacharczuk M.
• Języki publikacji: EN

Abstrakty

EN

Ectopic scrotum and ectopic testis are both rare conditions. This report describes a 9-year-old crossbreed male dog with both abnormalities, which also has T721C transition in the gene of epidermal growth factor receptor resulted in a Tyr241His substitution in the peptide chain and the second silent A111G transition. High level of total estrogens (101.0 pg/ml), normal testosterone level (2.15 ng/ml) in blood, prostatic hyperplasia (46x44 mm) and hyperplastic epididymis were observed. Moreover, both testicles had signs of connective tissue hyperplasia in epididymis, vasodilation of pampiniform plexus and impairment of spermatogenesis in the left testicle. Both scrotums consisted of the same layers. This constellation of anatomical and genetic anomalies has not been previously described. We postulated that T721C polymorphism in the Egfr gene is one of the genetic factors in polygenic etiology of ectopic scrotum.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2015
• Tom: 33
• Numer: 4
• Opis fizyczny: p.425-430,fig.,ref.

Twórcy

autor

Ruszczak A.

• Department of Small Animal Diseases with Clinic, University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland

autor

Jurka P.

• Department of Small Animal Diseases with Clinic, University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland

autor

Kacprzak K.

• Department of Small Animal Diseases with Clinic, University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland

autor

Watroba M.

• Department of Small Animal Diseases with Clinic, University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland
• Department of Genomic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland

autor

Parada R.

• Department of Genomic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland

autor

Sacharczuk M.

• Department of Genomic, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 36A, 05-552 Magdalenka, Poland

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