Influence of glutamate injection into unilateral nucleus accumbens shell on behavioral response elicited by ipsilateral stimulation of the mesolimbic system

• Autorzy: Plucinska K. , Jerzemowska G. , Podlacha M.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: Food intake is regulated not only by homeostatic requirements but also by emotional factors. The nucleus accumbens, particularly its shell region (AcbSh) is a part of the mesolimbic dopaminergic system which is responsible for a positive emotional aspect of various homeostasis-relevant stimuli. In the present work, we tested the AcbSh involvement in feeding behavior using an experimental paradigm specifically designed to assess motivational vs. motor aspect of food ingestion. METHODS: In rats (n=4), feeding was evoked by electrical stimulation of the midbrain ventral tegmental area (a somatodendritic region of mesolimbic system) and assessed quantitatively with the use of the latency to feed/stimulation frequency curve shift paradigm before and after ipsilateral glutamate injection (dose 2.0 µg dissolved in 0.5 µl of distillated water) into AcbSh (distillated water injection as a control, volume: 0.5 µl). RESULTS: Effect of ipsilateral glutamate injection into the AcbSh on behavioral response following the VTA stimulation was varied. In three rats the percentage reaction threshold did not change significantly and was approximated the baseline (not exceed ±10%). We observed an increase/decrease in the reaction threshold by only +0.31%, +2.85% and −1.90% in comparison to the water injection. In one rat the feeding threshold reaction was changed by significantly more than 10%. This significant increase was about +19.40% as compared to the baseline (water injection). CONCLUSIONS: Glutamate AcbSh activation – the major terminal area of the mesolimbic system does not affect the behavior induced by stimulation of the dopaminergic cells at the level of VTA. Presumably a different effect observed in one rat is dependent on the injected place within the AcbSh area. Research was financed by the Polish National Science Centre (NCN); decision no: DEC-2013/09/N/NZ4/02195

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S92

Twórcy

autor

Plucinska K.

• Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland

autor

Jerzemowska G.

• Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland

autor

Podlacha M.

• Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland