Nesfatyna-1 - hormon o działaniu plejotropowym

• Autorzy: Tymicki G. , Puzio I. , Pawlowska-Olszewska M.

Warianty tytułu

EN

Nesfatin-1: Pleiotropic hormone

• Języki publikacji: PL

Abstrakty

EN

Nesfatin-1 was first identified in 2006 as an anorexigenic peptide involved in appetite regulation. It is expressed both in the central nervous system and in the peripheral tissues. The anatomical location of neurons expressing nesfatin-1 and its co-occurrence with other neurotransmitters in the CNS indicate that its physiological role involves not only the regulation of food intake, but also neuroendocrine regulation and autonomic control of internal organs and behavioral responses. It affects the functions of the digestive tract and the cardiovascular system and plays an important role in the regulation of water intake, sleep, and reproductive functions. It plays an important role in the mechanism of metabolic control of the body, regulation of energy balance and body temperature, and development of obesity. Nevertheless, both the main source of nesfatin-1 in the circulation and the exact mechanisms of its functioning are not fully understood. Considering the pleiotropic effect of nesfatin-1, the relationship between the degree of body fatness and the risk of various diseases and the increase in the expression of nesfatin-1 in adipocytes with the development of obesity, it can be assumed that in the near future it will be taken into account as an important factor in the development, and perhaps treatment, of various diseases.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2020
• Tom: 76
• Numer: 03
• Opis fizyczny: s.136-144,rys.,bibliogr.

Twórcy

autor

Tymicki G.

• Katedra Fizjologii Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul. Akademicka 12, 20-033 Lublin

autor

Puzio I.

• Katedra Fizjologii Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul. Akademicka 12, 20-033 Lublin

autor

Pawlowska-Olszewska M.

• Katedra Fizjologii Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul. Akademicka 12, 20-033 Lublin

Bibliografia

• 1. Abici A., Catli G., Anik A., Kume T., Bober E.: The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children. Pediatric Diabetes 2013, 14, 3, 189-195.
• 2. Ademoglu E. N., Gorar S., Carhoglu A., Yazici H., Dellal F. D., Berberoglu Z., Akdeniz D., Uysal S., Karakurt F.: Plasma nesfatin-1 level are increased in patients with polycystic ovary syndrome. J. Endocrinol. Invest. 2014, 37, 715-719.
• 3. Angelone T., Filice E., Pasqua T., Amodio N., Galluccio M., Montesanti G., Quintieri A. M., Cerra M. C.: Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury. Cell. Mol. Life Sci. 2013, 70, 495-509.
• 4. Anwar G. M., Yamamah G., Ibrahim A., El-Lebedy D., Farid T. M., Mohmoud R.: Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance. Reg. Pep. 2014, 188, 21-24.
• 5. Atsuchi K., Asakawa A., Ushikai M., Ataka K., Tsai M., Koyama K., Yuki S., Ikuo K., Mineko F., Akio I.: Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. Neuroreport 2010, 21, 1008-1011.
• 6. Ayada C., Turgut G., Turgut S., Guclu Z.: The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: related with circulating level of blood pressure regulators. Gen. Physiol. Biophys. 2015, 34, 81-88.
• 7. Aydin S.: The presence of the peptides apelin, ghrelin and nesfatin-1 in the human breast milk, and the lowering of their levels in patients with gestational diabetes mellitus. Peptides 2010, 31, 2236-2240.
• 8. Aydin S., Dag E., Ozkan Y., Erman F., Dagli A. F., Kilic N., Sahin I., Karatas F., Yoldas T., Barim A. O., Kendir Y.: Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders. Mol. Cell. Biochem. 2009, 328, 49-56.
• 9. Bonnet M. S., Djelloul M., Tillement V., Tardivel C., Mounien L., Trouslard J., Troadec J.-D., Dallaporta M.: Central NUCB2/nesfatin-1-expressing neurons belong to the hypothalamic-brainstem circuitry activated by hypoglycaemia. J. Neuroendocrinol. 2013, 25, 1, 1-13.
• 10. Brailoiu G. C., Dun S. L., Brailoiu E., Inan S., Yang J., Chang J. K., Dun N. J.: Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinol. 2007, 148, 5088-5094.
• 11. Bundzikova-Osacka J., Ghosal S., Packard B. A., Ulrich-Lai Y. M., Herman J. P.: Role of nucleus of the solitary tract noradrenergic neurons in post-stress cardiovascular and hormonal control in male rats. Stress 2015, 18, 221-232.
• 12. Butler A. A.: More news about NUCB2/nesfatin-1: a new factor in the hypothalamic control of glucose homeostasis? Diabetes 2012, 61, 1920-1922.
• 13. Catli G., Abici A., Bober A. A. E.: Low serum nesfatin-1 levels may be a contributing factor for monogenic obesity due to prohormone convertase 1 deficiency. Med. Hypothesis 2013, 81, 2, 172-174.
• 14. Cano G., Passerin A. M., Schiltz J. C., Card J. P., Morrison S. F., Sved A. F.: Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J. Comp. Neurol. 2003, 460, 303-326.
• 15. Chen X., Dong J., Jiang Z. Y.: Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake. Regul. Pept. 2012, 177, 21-26.
• 16. Copinschi G., Leproult R., Spiegel K.: The important role of sleep in metabolism. Front. Horm. Res. 2014, 42, 59-72.
• 17. Coughlin J. W., Smith M. T.: Sleep, obesity, and weight loss in adults: is there arationale for providing sleep interventions in the treatment of obesity. International Rev. Psych. 2014, 26, 177-188.
• 18. Dai H., Li X., He T., Wang Y., Wang Z., Wang S., Xing M., Sun W., Ding H.: Decreased plasma nesfatin-1 levels in patients with acute mycordial infarction. Peptides 2013, 46, 167-171.
• 19. Deniz R., Gurates B., Aydin A., Celik H., Sahin I., Baykus Y., Catak Z., AksoyA., Citil C., Gungor S.: Nesfatin and other hormone alterations in polycystic ovary syndrome. Endocrine 2012, 42, 694-699.
• 20. Diggs-Andrews K. A., Zhang X., Song Z., Daphna-Iken D., Routh V. H., Fisher S. J.: Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes 2010, 59, 2271-2280.
• 21. Dong J., Guan H. Z., Jiang Z. Y., Chen X.: Nesfatin-1 influences the excitability of glucosensing neurons in the dorsal vagal complex and inhibits food intake. PLoS ONE 2014, 9(6):e98967.
• 22. Dong J., Xu H., Wang P.-F., Cai G.-J., Song H.-F., Wang C.-C., Dong Z.-T., Ju Y.-J., Jiang Z.-Y.: Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice. PLoS 2013, 8(12):e83397.
• 23. Erdos B., Clifton R. R., Liu M., Li H., McCowan M. L., Sumners C., Scheuer D. A.: Novel mechanism within the paraventricular nucleus reduces both blood pressure and hypothalamic pituitary-adrenal axis responses to acute stress. Am. J. Physiol. Heart Circ. Physiol. 2015, 309, 4, 634-645.
• 24. Fan W., Voss A. A., Cao W. H., Morrison S. F.: Regulation of thermogenesis by the central melanocortin system. Peptides 2005, 26, 1800-1813.
• 25. Feijoo-Bandın S., Rodrıguez-Penas D., Garcıa-Rua V., Mosquera-Leal A., Otero M. F., Pereira E., Rubio J., Martinez I., Seoane L. M., Calaza O. G. M., Garcia-Caballero T., Portoles M., Rosello-Lleti E., Dieguez C., Rivera M., Gonzalez-Juanatey J. R., Lago F.: Nesfatin-1 in human and murine cardiomyocytes: synthesis, secretion, and mobilization of GLUT-4. Endocrinol. 2013, 154, 4757-4767.
• 26. Fernandez-Fernandez R., Martini A. C., Navarro V. M. Castellano J. M., Dieguez C., Aguilar E., Pinilla L., Tena-Sempere M.: Novel signals for the integration of energy balance and reproduction. Mol. Cell. Endocrinol. 2006, 254-255, 127-132.
• 27. Foo K. S. Brauner H., Ostenson C.-O., Broberger C.: Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J. Endocrinol. 2010, 204, 255-263.
• 28. Foo K. S., Brismar H., Broberger C.: Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008, 156, 563-579.
• 29. Fort P., Salvert D., Hanriot L., Jego S., Shimizu H., Hashimoto K., Mori M., Luppi P. H.: The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat. Neuroscience 2008, 155, 174-181.
• 30. Gaige S., Bonnet M. S., Tardivel C., Pinton P., Trouslard J., Jean A., Guzylack L., Troadec J.-D., Dallaporta M.: c-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Neurotoxicology 2013, 34, 135-149.
• 31. Gantulga D., Maejima Y., Nakata M., Yada T.: Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus. Bioch. Bioph. Res. Comm. 2012, 420, 4, 811-815.
• 32. Gao X., Zhang K., Song M., Li X., Luo L., Tian Y., Zhang Y., Li Y., Zhang X., Ling Y., Fang F., Liu Y.: Role of nesfatin-1 in the reproductive axis of male rat. Sci. Rep. 2016, 6, 32877.
• 33. Garcia-Galiano D., Navarro V. M., Gaytan F., Tena-Sempere M.: Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation. J. Mol. Endocrinol. 2010, 45, 281-290.
• 34. Garcia-Galiano D., Navarro V. M., Roa J., Ruiz-Pino F., Sanchez-Garrido M. A., Pineda R., Castellano J. M., Romero M., Aguilar E., Gaytan F., Dieguez C., Pinilla L., Tena-Sempre M.: The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J. Neurosci. 2010, 30, 7783-7792.
• 35. Garcia-Galiano D., Pineda R., Ilhan T., Castellano J. M., Ruiz- Pino F., Sanchez-Garrido M. A., Vazquez M. J., Sangiao-Alvarellos S., Romero-RuizA., Dieguez L. P. C., Gaytan F., Tena-Sempre M.: Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinol. 2012, 153, 1959-1971.
• 36. Garcia-Garcia F., Juarez-Aguilar E., Santiago-Garcia J., Cardinali D. P.: Ghrelin andits interactions with growth hormone, leptin and orexins: implications forthe sleep-wake cycle and metabolism. Sleep. Med. Rev. 2014, 18, 89-97.
• 37. Goebel M., Stengel A., Wang L., Lambrecht N. W. G., Taché Y.: Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei. Neurosci. Lett. 2009, 452, 241-246.
• 38. Goebel M., Stengel A., Wang L., Taché Y.: Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals. Peptides 2011, 32, 36-43.
• 39. Gonkowski S., Rychlik A., Nowicki M., Nieradka R., Bulc M., Całka J.: Apopulation of nesfatin 1-like immunoreactive (LI) cells in the mucosal layer of the canine digestive tract. Res. Vet. Sci. 2012, 93, 1119-1121.
• 40. Gonzalez R., Kerbel B., Chun A., Unniappan S.: Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish. PLoS ONE 2010, 5(12): e15201.
• 41. Gonzalez R., Perry R. L. S., Gaidhu M. P., Tsushima R. G., Ceddia R. B., Unniappan S.: Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secrection in rats. Endocrinol. 2011, 152, 10, 3628-3637.
• 42. Gonzalez R., Shepperd E., Thiruppugazh V., Lohan S., Grey C. L., Chang J. P., Unniappan S.: Nesfatin-1 regulates the hypothalamo-pituitary-ovarian axis of fish. Biol. Reprod. 2012, 87 (4), 84.
• 43. Gonzalez R., Tiwari A., Unniappan S.: Pancreatic beta cells colocalize insulin and pronesfatinimmunoreactivity in rodents. Biochem. Biophys. Res. Commun. 2009, 381, 643-648.
• 44. Guo F.-F., Xu L., Gao S.-L., Sun X.-R., Li Z.-L., Gong Y.-L.: The effects of nesfatin-1 in the paraventricular nucleus on gastric motility and its potential regulation by the lateral hypothalamic area in rats. JNC 2015, 132, 3, 266-275.
• 45. Hill J. W., Elmquist J. K., Elias C. F.: Hypothalamic pathways linking energy balance and reproduction. Am. J. Physiol. Endocrinol. Metab. 2008, 294, 827-832.
• 46. Inhoff T., Stengel A., Peter L., Goebel M., Tache Y., Bannert N., Wiedenmann B., Klapp B. F., Monnikes H., Kobelt P.: Novel insight in distribution of nesfatin-1 and phosphor mTOR in the arcuate nucleus of the hypothalamus of rats. Peptides 2010, 31, 257-262.
• 47. Iwasaki Y., Nakabayashi H., Kakei M., Shimizu H., Mori M., Yada T.: Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels. Biochem. Biophys. Res. Comm. 2009, 390, 3, 958-962.
• 48. Jego S., Salvert D., Renouard L., Mori M., Goutagny R., Luppi P.-H., Fort P.: Tuberal hypothalamic neurons secreting the satiety molecule nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis. PLoS 2012, 7(12):e52525.
• 49. Jiang L., Bao J., Zhou X., Xiong Y., Wu L.: Increased serum levels and chondrocyte expression of nesfatin-1 in patients with osteoarthritis and its relation with BMI, hsCRP, and IL-18. Mediators Inflamm. 2013, 631251.
• 50. Kawabe T., Kawabe K., Sapru H. N.: Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. PLoS One 2012, 7(9):e45180.
• 51. Kerbel B., Unniappan S.: Nesfatin-1 suppresses energy intake, co-localises ghrelin in the brain and gut, and alters ghrelin, cholecystokinin and orexin mRNA expression in goldfish. J. Neuroendocrinol. 2012, 24, 366-377.
• 52. Kim J., Chung Y., Kim H., Im E., Lee H., Yang H.: The tissue distribution of nesfatin 1/NUCB2 in mouse. Dev. Reprod. 2014, 18, 301-309.
• 53. Kohno D., Nakata M., Maejima Y., Shimizu H., Sedbazar U., Yoshida N., Dezaki K., Onaka T., Mori M., Yada T.: Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinol. 2008, 149, 1295-1301.
• 54. Kolgazi M., Cantali-Ozturk C., Deniz R., Ozdemir-Kumral Z. N., Yuksel M., Sirvanci S., Yegen B. C.: Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms. JSR 2015, 193, 1, 111-118.
• 55. Konczol K., Pinter O., Ferenczi S., Varga J., Kovacs K., Palkovits M., Zelena D., Toth Z. E.: Nesfatin-1 exerts long-term effect on food intake and body temperature. Int. J. Obesity 2012, 36, 1514-1521.
• 56. Kong W. M., Stanley S., Gardiner J., Abbott C., Murphy K., Seth A., Connoley I., Ghatei M., Stephens D., Bloom S.: A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation. Faseb. J. 2003, 17, 1688-1690.
• 57. Kuksis M., Ferguson A. V.: Cellular actions of nesfatin-1 in the subfornical organ. J. Neuroendocrin. 2014, 26, 237-246.
• 58. Lechan R. M., Fekete C.: The TRH neuron: a hypothalamic integrator of energy metabolism. Prog. Brain Res. 2006, 153, 209-235.
• 59. Lents C. A., Barb C. R., Hausman G. J., Nonneman D., Heidorn N. L., Cisse R. S., Azain M. J.: Effects of nesfatin-1 on food intake and LH secretion in prepubertal gilts and genomic association of the porcine NUCB2 gene with growth traits. Domest. Anim. Endocrinol. 2013, 45, 89-97.
• 60. Li Q.-C., Wang H.-Y., Chen X., Guan H.-Z., Jiang Z.-Y.: Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul. Pept. 2010, 159, 72-77.
• 61. Li Z., Gao L., Tang H., Yin Y., Xiang X., Li Y., Zhai J., Mulholland M., Zhang W.: Peripheral effects on nesfatin-1 on glucose homeostasis. PLoS 2013, 8(8):e71513.
• 62. Lin F., Zhou C., Chen H., Wu H., Xin Z., Liu J., Gao Y., Yuan D., Wang T., Wei R., Chen D., Yang S., Wang Y., Pu Y., Li Z.: Molecular characterization, tissue distribution and feeding related changes of NUCB2A/nesfatin-1 in Ya-fish (Schizothorax prenanti). Gene 2014, 536, 238-246.
• 63. Maejima Y., Sedbazar U., Suyama S., Kohno D., Onaka T., Takano E., Yoshida N., Koike M., Uchiyama Y., Fujiwara K., Yashiro T., Horvath T. L., Dietrich M. O., Tanaka S., Dezaki K., Oh-I S., Hashimoto K., Shimizu H., Nakata M., Mori M., Yada T.: Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell. Metab. 2009, 10, 355-365.
• 64. Mazza R., Gattuso A., Filice M., Cantafio P., Cerra M. C., Angelone T., Imbrogno S.: Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart. Gen. Comp. Endocrinol. 2015, 224, 160-167.
• 65. Miura K., Titani K., Kurosawa Y., Kanai Y.: Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. Biochem. Biophys. Res. Comm. 1992, 187, 375-380.
• 66. Miyata S., Yamada N., Kawada T.: Possible involvement of hypothalamic nucleobindin-2 in hyperphagic feeding in Tsumura Suzuki obese diabetes mice. Biol. Pharm. Bull. 2012, 35, 10, 1784-1793.
• 67. Moreau J. M., Ciriello J.: Nesfatin-1 induces Fos expression and elicits dipsogenic responses in subfornical organ. Behav. Brain Res. 2013, 250, 343-350.
• 68. Mortazavi S., Gonzalez R., Ceddia R., Unniappan S.: Long-term infusion of nesfatin-1 causes a sustained regulation of whole-body energy homeostasis of male Fischer 344 rats. Front. Cell Dev. Biol. 2015, 3, 22.
• 69. Nakamura K., Morrison S. F.: Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am. J. Physiol. 2007, 292, 1, 127-136.
• 70. Nakata M., Manaka K., Yamamoto S., Mori M., Yada T.: Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca2+ influx through L-type channels in mouse islet β-cells. Endocrine J. 2011, 58, 4, 305-313.
• 71. Oh-I S., Shimizu H., Satoh T., Okada S., Adachi S., Inoue K., Eguchi H., Yamamoto M., Imaki T., Hashimoto K., Tsuchiya T., Monden T., Horiguchi K., Yamada M., Mori M.: Identification of nesfatin 1 as a satiety molecule in the hypothalamus. Nature 2006, 443, 709-712.
• 72. Okere B., Xu L., Roubos E. W., Sonetti D., Kozicz T.: Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse EdingerWestphal nucleus. Brain Res. 2010, 1317, 92-99.
• 73. Osaki A., Shimizu H.: Peripheral administration of nesfatin-1 increases blood pressure in mice. Hypertension Res. 2014, 37, 185-186.
• 74. Ozkan Y., Suay E., Aydin S., Sahin I., Timurkan M., Citil C., Kalayci M., Yilmaz M., Aksoy A., Catak Z.: Acylated and desacylatedghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index. Int. J. Endocrin. 2013, 236085.
• 75. Piya M. K., McTernan P. G., Kumar S.: Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin. J. Endocrinol. 2013, 216, 1-15.
• 76. Price C. J., Samson W. K., Ferguson A. V.: Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res. 2008, 1230, 99-106.
• 77. Ramanjaneya M., Addison M., Randeva H. S.: Possible role of NUCB2/ nesfatin-1 in adipogenesis. Curr. Pharm. Des. 2013, 19, 39, 6976-6980.
• 78. Ramanjaneya M., Chen J., Brown J. E., Tripathi G., Hallschmid M., Patel S., Kern W., E. W., Lehnert H.: Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinol. 2010, 151, 3169-3180.
• 79. Riva M., Nitert M. D., Voss U., Sathanoori R., Lindqvist A., Ling C., Wierup N.: Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects. Cell Tissue Res. 2011, 346, 3, 393-405.
• 80. Sahin F. K., Sahin S. B., Ural U. M., Cure M. C., Senturk S., Tekin Y. B., Balik G., Cure E., Yuce S., Kirbas A.: Nesfatin-1 and vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycistic ovary syndrome. Bosn. J. Basic Med. Sci. 2015, 15, 3, 57-63.
• 81. Sakurai T.: Hypothalamic neuropeptides implicated in the regulation of sleep/ wakefulness states. Brain Nerve 2012, 64, 629-637.
• 82. Senejani A. G., Gaupale T. C., Unniappan S., Bhargava S.: Nesfatin-1/nucleobindin-2 like immunoreactivity in the olfactory system, brain and pituitary of frog, Microhyla ornata. Gen. Comp. Endocrinol. 2014, 202, 8-14.
• 83. Senin L. L., Al-Massadi O., Barja-Fernandez S., Folgueira C., Castelao C., Tovar S. A., Leis R., Lago F., Baltar J., Baamonde I., Dieguez C., Casanueva F. F., Seoane L. M.: Regulation of NUCB2/nesfatin-1 production in rat’s stomach and adipose tissue is dependent on age, testosterone levels and lactating status. Mol. Cell. Endocrinol. 2015, 41, 105-112.
• 84. Shimizu H., Oh-I S., Hashimoto K., Nakata M., Yamamoto S., Yoshida N., Eguchi H., Kato I., Inoue K., Satoh T., Okada S., Yamada M., Yada T., Mori M.: Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinol. 2009, 150, 662-671.
• 85. Shimizu H., Oh-I S., Okada S., Mori M.: Nesfatin-1: An Overview and Future Clinical Application. Endocrine Journal 2009, 56, 4, 537-54.
• 86. Stengel A.: Nesfatin-1 – More than a food intake regulatory peptide. Peptides 2015, 72, 175-183.
• 87. Stengel A., Goebel M., Tache Y.: Nesfatin-1: a novel inhibitory regulator of food intake and body weight. Obes. Rev. 2011, 12, 261-271.
• 88. Stengel A., Goebel M., Wang L., Rivier J., Kobelt P., Monnikes H., Lambrecht N. W., Tache Y.: Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinol. 2009, 150, 4911-4919.
• 89. Stengel A., Goebel M., Wang L., Tache Y.: Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: Role as regulators of food intake and body weight. Peptides 2010, 31, 2, 357-369.
• 90. Stengel A., Goebel M., Yakubov I., Wang L., Witcher D., Coskun T., Tache Y., Sachs G., Lambrecht N. W.: Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinol. 2009, 150, 232-238.
• 91. Stengel A., Hofmann T., Goebel-Stengel M., Lembke V., Ahnis A., Elbelt U., Lambrecht N. W. G., Ordemann J., Klapp B. F., Kobelt P.: Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects. Histochem. Cell Biol. 2013, 139, 909-918.
• 92. Su Y., Zhang J., Tang Y., Bi F., Liu J. N.: The novel function of nesfatin-1: anti hyperglycemia. Biochem. Biophys. Res. Com. 2010, 391, 1039-1042.
• 93. Szlachcic A., Śliwowski Z., Krzysiek-Mączka G., Majka J., Surmiak M., Pajdo R., Drozdowicz D., Konturek S. J., Brzozowski T.: New satiety hormone nesfatin-1 protects gastric mucosa against stress-induced injury: Mechanistic roles of prostaglandins, nitric oxide, sensory nerves and vanilloid receptors. Peptides 2013, 49, 9-20.
• 94. Tadross J. A., Patterson M., Wynne K. J., Patel S., Suzuki K., Ghatei M. A., Bloom S. R.: Nesfatin suppresses feeding and stimulates the hypothalamo-pituitary-gonadal axis. Endocrine J. 2010, 57 (Suppl. 2) S355-S648. Abstract P3-1-3.
• 95. Tagaya Y., Miura A., Okada S., Ohshima K., Mori M.: Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation. Endocrinol. 2012, 153, 7, 3308-3319.
• 96. Tan B. K., Hallschmid M., Kern W., Lehnert H., Randeva S.: Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment. JCEM 2011, 96, 4, 669-673.
• 97. Tanida M., Mori M.: Nesfatin-1 stimulates renal sympathetic nerve activity in rats. Neuroreport 2011, 22, 6, 309-312.
• 98. Tian Z. B., Deng R. J., Sun G. R., Wei L. Z., Kong X. J., Ding X. L., Jing X., Zhang C. P., Ge Y. L.: Expression of gastrointestinal nesfatin-1 and gastric emptying in ventromedial hypothalamic nucleus- and ventrolateral hypothalamic nucleus-lesioned rats. World J. Gastroenterol. 2014, 20, 22, 6897-6905.
• 99. Tsuchiya T., Shimizu H., Yamada M., Osaki A., Oh-I S., Ariyama Y., Takahashi H., Okada S., Hashimoto K., Satoh T., Kojima M., Mori M.: Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clinic. Endocrin. 2010, 73, 4, 484-490.
• 100. Varricchio E., Russolillo M. G., Russo F., Lombardi V., Paolucci M., Maruccio L.: Expression and immunohistochemical detection of nesfatin-1 in the gastrointestinal tract of Casertana pig. Acta Histochemica 2014, 116, 4, 583-587.
• 101. Vas S., Adori C., Konczol K., Katai Z., Pap D., Papp R. S., Bagdy G., Palkovits M., Toth Z.: Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats. PLoS ONE 2013, 8, 4.
• 102. Voss U., Riva M., Dekker N. M. N., Ling C., Lindqvist A., Wierup N.: Nesfatin-1 stimulates insulin secretion, inhibits glucagon secretion and is expressed in human and rodent beta cells. Diabetologia 2010, 53, (Suppl. 1), s. 222.
• 103. Wang Q., Guo F., Sun X., Gao S., Li Z., Gong Y., Xu L.: Effects of exogenous nesfatin-1 on gastric distention-sensitive neurons in the central nucleus of the amygdala and gastric motility in rats. Neurosci. Lett. 2014, 582, 65-70.
• 104. Watanabe A., Mochiki E., Kimura A., Kogure N., Yanai M., Ogawa A., Toyomasu Y., Ogata K., Ohno T., Suzuki H., Kuwano H.: Nesfatin-1 suppresses gastric contractions and inhibits interdigestive migrating contractions in conscious dogs. Dig. Dis. Sci. 2015, 60, 6, 1595-1602.
• 105. Wernecke K., Lamprecht I., Johren O., Lehnert H., Schulz C.: Nesfatin-1 increases energy expenditure and reduces food intake in rats. Obesity (Silver Spring) 2014, 22, 1662-1668.
• 106. Wu D., Yang M., Chen Y., Jia Y., Ma Z. A., Boden G., Li L., Yang G.: Hypothalamic nesfatin-1/NUCB2 knockdown augments hepatic gluconeogenesis that is correlated with inhibition of mTOR-STAT3 signaling pathway in rats. Diabetes 2014, 63, 4, 1234-1247.
• 107. Xia Z. F., Fritze D. M., Li J. Y., Chai B., Zhang C., Zhang W., Mulholland M. W.: Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303, 570-577.
• 108. Yamawaki H., Takahashi M., Mukohda M., Morita T., Okada M., Hara Y.: A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem. Biophys. Res. Commun. 2012, 418, 4, 676-681.
• 109. Yang M., Zhang Z., Wang C., Li K., Li S., Boden G., Li L., Yang G.: Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes 2012, 61, 1959-1968.
• 110. Yosten G. L., Redlinger L., Samson W. K.: Evidence for a role of endogenous nesfatin-1 in the control of water drinking. J. Neuroendocrinol. 2012, 24, 1078-1084.
• 111. Yosten G. L., Samson W. K.: Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 297, 330-336.
• 112. Yosten G. L., Samson W. K.: The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010, 298, 1642-1647.
• 113. Zegers D., Beckers S., Freitas F., Jennes K., Van Camp J. K., Martens I. L., Van Hoorenbeeck K., Rooman R. P., Desager K. N., Massa G., Van Gaal L. f., Van Hul W.: Identification of mutations in the NUCB2/nesfatin gene in children with severe obesity. Molec. Genetics Metab. 2012, 107, 4, 729-734.
• 114. Zegers D., Beckers S., Mertens I. L., Van Gaal L. F., Van Hul W.: Association between polymorphisms of the Nesfatin gene, NUCB2, and obesity in men. Molec. Genetics Metab 2011, 103, 3, 282-286.
• 115. Zhang A.-Q.: Expression of nesfatin-1/NUCB2 in rodent digestive system. World J. Gastroenterol. 2010, 16, 1735-1741.
• 116. Zhang Y., Shui X., Lian X., Wang G.: Serum and synovial fluid nesfatin-1 concentration is associated with radiographic severity of knee osteoarthritis. Med. Sci. Monit. 2015, 21, 1078-1082.
• 117. Zhao Y., Ma X., Wang Q., Zhou Y., Zhang Y., Wu L., Ji H., Qin G., Lu J., Bi Y., Ning G.: Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population. Clin. Exp. Hypertension 2014, 37, 1, 51-56.

Identyfikatory

DOI

10.21521/mw.6329