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2011 | 71 | 2 |
Tytuł artykułu

Up-regulation of cochlear Hes1 expression in response to noise exposure

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hes l, a hairy and enhancer of split homolog, negatively regulates inner ear hair cell differentiation. The main objective of this study was to investigate the status of the Hes l gene in the noise-damaged cochlea in relation to the degree of noise-induced hearing loss (NIHL). Adult albino guinea pigs were exposed to white-band noise (115 dB sound pressure level). Noise exposure for either 1 or hours induced significant elevations of threshold in auditory brainstem response (ABR) compared with unexposed controls. Succinate dehydrogenase staining showed that white-band noise exposure caused significant outer hair cell losses. In addition, we found significant up-regulations of cochlear Hesl mRNA and protein expressions following acoustic trauma, and Hesl mRNA expression was positively correlated with NIHL. These findings suggest that up-regulation of Hes l expression in response to noise exposure may be one of the underlying mechanisms of NIHL.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
2
Opis fizyczny
p.256-262,fig.,ref.
Twórcy
autor
  • Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China
  • Department of Physiology, Second Military Medical University, Shanghai, P.R. China
autor
  • Department of Pathophysiology, Second Military Medical University, Shanghai, P.R. China
autor
  • Department of Physiology, Second Military Medical University, Shanghai, P.R. China
autor
  • Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China
autor
  • Department of Physiology, Second Military Medical University, Shanghai, P.R. China
autor
  • Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, P.R. China
Bibliografia
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