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2015 | 14 | 2 |
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Antioxidant activities of leaf galls extracts of terminalia chebula (Gaertn.) retz. (Combretaceae)

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Background. Free radicals are implicated in several metabolic diseases and the antioxidant therapy has gained an utmost importance in the treatment. The medicinal properties of plants have been investigated and explored for their potent antioxidant activities to counteract metabolic disorders. In this study, the chemical composition and free radical scavenging potential of leaf gall extracts (ethanol, petroleum ether, chloroform and aqueous) of Terminelia chebula is evaluated, which is extensively used in the preparation of traditional medications to treat various metabolic diseases. Material and methods. The presences of phenolics, flavonoids, triterpens, saponins, glycosides, phytosterols, reducing sugars were identified in the extracts according to standard procedures. The free radical scavenging activities of the extract were also analysed by standard procedures. Results. The methanol extract had the highest total phenolic and flavonoid content. The antioxidant activities of leaf gall extracts were examined using diphenylpicrylhydrazyl (DPPH), Super oxide radical scavenging, Hydroxyl scavenging and ferric reducing power (FRAP) methods. In all the methods, the ethanolic extract showed higher free radical scavenging potential than all the other extracts. Conclusion. As the higher content of both total phenolics and flavonoids were found in the ethanolic extract, so the significantly high antioxidant activity can be positively correlated to the high content of total polyphenols/flavonoids of the ethanol extract. The results of this study confirm the folklore use of I chebula leaves gall extracts as a natural antioxidant and justify its ethnobotanical use. Further, the results of antioxidant properties encourage the use of T. chebula leave gall extracts for medicinal health, functional food and nu- traceutical applications.
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  • Department of Chemistry, School of Graduate Studies, Jain University Bangalore, 560002 Bangalore, India
  • Research Unit in Vrukshayurveda, A Division of Centre for Advanced Studies in Biosciences, Jain University Bangalore, 560019 Bangalore, Chamrajpete, India
  • PG Department of Studies and Research in Biotechnology, Kuvempu University Shankarghatta, 577451 Shankarghatta, Karnataka, India
  • PG Department of Studies and Research in Biotechnology, Kuvempu University Shankarghatta, 577451 Shankarghatta, Karnataka, India
  • Research Unit in Vrukshayurveda, A Division of Centre for Advanced Studies in Biosciences, Jain University Bangalore, 560019 Bangalore, Chamrajpete, India
  • Research Unit in Vrukshayurveda, A Division of Centre for Advanced Studies in Biosciences, Jain University Bangalore, 560019 Bangalore, Chamrajpete, India
  • Department of Biochemistry, University of Mysore, Mysore 570006, Karnataka, India
  • Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies (CET), Jain University Ramanagara, 562112 Ramanagara, Kanakpura Taluk, India
  • Al-Reza, S. M., Rahman, A., Kang, S. C. (2009). Chemical composition and inhibitory effect of essential oil and organic extracts of Cestrum nocturnum L. on food-borne pathogens. Int. J. Food Sci. Technol., 44, 1176-1182.
  • Auudy, B., Ferreira, F., Blasina, L., Lafon, F., Arredondo, F., Dajas, R., Tripathi, P. C. (2003). Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. J. Ethnopharm., 84, 131-138.
  • Blois, M. S. (1958). Antioxidants determination by the use of a stable free radical. Nature, 181, 1199-1200.
  • Chang, C., Yang, M., Wen, H., Chem, J. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J. Food Drug Anal. 10(3), 178-182.
  • Choi, Y., Jeong, H. S., Lee, J. (2007). Antioxidant activity of methanolic extracts from some grains consumed in Korea. Food Chem., 103, 130-138.
  • Das, N. P., Pereira, T. A. (1990). Effects of flavanoids on thermal autooxidation of palm oil: structure activity relationship. J. Am. Oil Chem. Soc., 67, 255-258.
  • Decker, E. A. (1997). Phenolics: prooxidants or antioxidants? Nutr. Rev., 55, 396-407.
  • Duh, P. D. (1998). Antioxidant activity of Budrock (Arctium laooa Linn.) its scavenging effect on free radical and active oxygen. J. Am. Oil Chem. Soc., 75, 455—461.
  • Gossell-Williams, M., Simon, O. R., Westm, M. E. (2006). The past and present use of plants for medicines. West. Indian Med. J., 55, 217-218.
  • Gunakari Ayurvediy Aushadhe. Ayurveda Rasashala, Pune.
  • Halliwell, B. (1997). Antioxidants and human disease: a general introduction. Nut. Rev., 55, 44-52.
  • Halliwell, B., Grootveld, M., Gutteridge, J. M. C. (1988). Methods for the measurement of hydroxyl radicals in biochemical systems: deoxyribose degradation and aromatic hydroxylation. Meth. Biochem. Anal. 33, 59-90.
  • Harbome, J. J. (1984). Phytochemical methods: A guide to modem techniques of plant analysis. New York: Chapman and Hall.
  • Kaur, C., Kapoor, H. C. (2002). Anti-oxidant activity and total phenolic content of some Asian vegetables. Int. J. Food Sci. Technol., 37, 153-161.
  • Kessler, M., Ubeaud, G., Jung, L. (2003). Anti- and pro-oxi- dant activity of rutin and quercetin derivatives. J. Pharm. Pharmacol., 55, 131-142.
  • Khandelwal, K. R. (2005). Practical pharmacognosy: Techniques and experiments (pp. 149-156). Pune: Nirali Prakashan.
  • Kokate, C. K., Purohit, A. P., Gokhale, S. B. (1998). Pharmacognosy (pp. 106-114). Pune: Nirali Prakashan.
  • Manosroi, A., Jantrawut, P., Akazawa, H., Akihisa, T., Ma- nosroi, J. (2010). Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae). Nat. Prod. Res., 24(20), 1915-1926.
  • Manosroi, A., Jantrawut, P., Akihisa, T., Manosroi, W., Manosroi, J. (2011). In vitro and in vivo skin anti-aging evaluation of gel containing noisomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula gi\\s. Pharm. Biol., 49(11), 1190-1203.
  • Manosroi, A., Jantrawut, P., Ogihara, E., Yamamoto, A., Fukatsu, M., Yasukawa, K., Tokuda, H., Suzuki, N., Manosroi, J., Akihisa, T. (2013). Biological activities of phenolic compounds and triterpenoids from the galls of Terminalia chebula. Chem. Biodiv., 10(8), 1448-1463.
  • Mohamed, A. A., Khalil, A. A., El-Beltagi, H. E. S. (2010). Antioxidant and antimicrobial properties of kaff maryam (Anastatica hierochuntica) and doum palm (Hyphaene thebaica). Grasas Aceites, 61(1), 67-75.
  • Nadkarni, K. M. (1976). Indian materia medica (pp. 1062 -1063). India: Popular Prakashan.
  • Naik, G. H., Priyadarsini, K. I., Satav, J. G., Banavalikar, M. M., Sohoni, D. P., Biyani, M. K. (2003). Comparative antioxidant activity of individual herbal components used in ayurvedic medicine. Phytochem., 63, 97-104.
  • Nishikimi, M., Appaji, N., Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem. Biophys. Res. Commun., 46(2), 849-854.
  • Rice-Evans, C. A., Miller, N. J., Bolwell, P. G., Bramley, P. M., Pridham, J. B. (1995). The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Rad. Res., 23, 375-383.
  • Santha, T. R., Shetty, J. K., Yoganarasimhan, S. N., Sud- ha, R. (1991). Farmacognostical staudies on the South Indian market sample of karkatasringi (kudukkaipoo) - terminalia chebul (Gaertn. Leaf gall). Anc. Sci. Life, 11(1-2), 16-22.
  • Shankara, B. E. R., Ramachandra, Y. L., Sundara Rajan, S., Preetham, J., Sujan Ganapathy, P. S. (2012). In vitro antibacterial activity of Terminalia chebula leaf gall extracts against some human pathogenic strains. Inti. Curr. Pharm. J., 1(8), 217-220.
  • Shimada, K., Fujikawa, K., Yahara, K., Nakamura, T. (1992). Antioxidative properties of xanthan on the autoxidation of soyabean oil in cyclodextrin emulsion. J. Agric. Food Chem., 40, 945-948.
  • Shrestha, S., Kaushik, V. S., Eshwarappa, R. S., Subaramaihha, S. R., Ramanna, L. M., Lakkappa, D. B. (2014). Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae). Asian Pac. J. Trop. Biomed., 4(1), 35-39.
  • Shrestha, S., Subaramaihha, S. R., Subbaiah, S. G., Eshwarappa, R. S., Lakkappa, D. B. (2013). Evaluating the antimicrobial activity of methanolic extract of rhus suc- cedanea leaf gall. Bioimpacts, 3(4), 195-198.
  • Sukh, D. (1997). Ethanotherapeutics and modern drug development. The potential of Ayurveda. Curr. Sci., 73, 909-928.
  • Sultana, B., Anwar, F., Przybylski, R. (2007). Antioxidant activity of phenolic components present in barks of barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam trees. Food Chem., 104, 1106-1114.
  • The Ayurvedic Formulary of India (Pt. I). 1978. Delhi, India: Goverment of India.
  • The Siddha Formulary of India. 1978. New Delhi: Goverment of India.
  • The Wealth of India: Raw Materials. Vol. 8. 1969. New Delhi, India: C.S.I.R.
  • Trease, G. E., Evans, W. C. (1989). Pharmacognosy. Delhi: ELBS Publ.
  • Upadhye, A. S., Rajopadhye, A. A. (2010). Pharmacognostic and phytochemical evaluation of leaf galls of Kakadshringi used in Indian system of medicine. J. Sci. Ind. Res., 69, 700-704.
  • Vonshak, A., Barazani, O., Sathiyamoorthy, P., Shalev, R., Vardy, D., Golan-Goldhirsh, A. (2003). Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother. Res., 17(9), 1123-1125.
  • Yildirim, A., Mavi, A., Oktay, M., Kara, A. A., Algur, O. F., Bilaloglu, V. (2000). Comparison of antioxidant and antimicrobial activities of Tilia (Tilia argentea Desf Ex DC), Sage (Salvia triloba L.), and Black Tea (Camellia sinensis) extracts. J. Agric. Food Chem., 48,5030-5034.
  • Zhao, H., Fan, W., Dong, J., Lu, J., Chen, J., ..., Shan, L. (2008). Evaluation of antioxidant activities and total phenolic contents of typical malting barley varieties. Food Chem, 107, 296-304.
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