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2015 | 20 | 2 |
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Effect of the addition of zinc and selenium ions on the stability of the Biolasol liquid used for perfusion, reperfusion and preservation of parenchymal organs of the abdominal cavity

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The Biolasol® liquid is an innovative solution used for perfusion, reperfusion and preservation of parenchymal organs of the abdominal cavity. Substances in the liquid prevent cellular oedema and help to maintain a proper water/mineral as well as acid/base balance in the intracellular environment. They also minimize free-radical injuries and ensure the integrity of the cellular membrane structure. The Biolasol® liquid has been shown to be much more efficient than the HTK liquid in the preservation of kidneys. The Biolasol® liquid containing 0.5 mM of vitamin C has been modified by adding ions of Se(IV), Zn(II), and their effect on the stability of the solution was examined. An accelerated aging test was applied to test the liquid stability. The test, based on the laws of chemical kinetics, was conducted at four temperatures at a 10°C step, that is: 50°C±0.05, 60°C±0.05, 70°C±0.05 and 80°C±0.05. The relative humidity equalled 75% of RH and the duartion of the test was 40 days. In order to determine the stability of the tested solutions, the Arrhenius Dependence equation was used, applied to the effect of temperature on the glucose decomposition reaction rate: lnk=lnA-(Ea/RT). The results indicate that the addition of zinc decreases the stability of the liquid by 30.5%, while the addition of selenium prolongs the stability by 8.21%. This is explained by the synergism of action of vitamin C and Se4+ antioxidant in the tested liquid. Zinc ions present in the solution increase the glucose decomposition reaction rate.
Opis fizyczny
  • Department of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
  • Department of Applied Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Sosnowiec, Poland
  • Department of General, Vascular and Transplant Surgery, School of Medicine, Medical University of Silesia, Katowice, Poland
  • Pharmaceutical Research and Production Plant "Biochefa", Sosnowiec, Poland
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