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2012 | 68 | 07 |
Tytuł artykułu

Metylowanie DNA u pszczoły miodnej (Apis mellifera) i jego wpływ na badania biologiczne

Treść / Zawartość
Warianty tytułu
EN
DNA methylation in the honey bee (Apis mellifera) and its importance for biological research
Języki publikacji
PL
Abstrakty
EN
The honey bee is the fourth insect following the drosophila, the silkworm and the anopheles - whose genome has been fully investigated. Eighty percent of the methylation-prone apian genes are located in the brain. Only about 70 thousand out of the 60 million cytosines contained in the bee genome are methylated. Most of them have their primary methylation sites in the exons. In contrast to the intensive human genome methylation, only small and specific segments of the honey bee genome are methylated. It is estimated that approximately 35-40% of apian genes are deficient in CpG groups. DNA methylation increases the incidence of mutations at the CpG sites and may promptly lead to inconsistency between DNA sequences. Methylation in A. mellifera occurs exclusively in CpG dinucleotides characterized by a bimodal configuration and deamination of methylated CpGs to TpGs (CpA in the supplementary strand), resulting in GC mutating into AT. Genes with a low and high CpG content (low-CpG and high-CpG) are active in various biological processes. The low-CpG genes are typical of hypermethylation and particularly important for metabolism, ubiquitination, gene expression and translation. The high-CpG genes, in turn, primarily participate in hypomethylation and are fundamental for development processes, intercellular communication and adhesion. The sparing methylation system (of bees) offers unique possibilities for the study of methylation using a model organism that is much simpler than most laboratory plants and animals, let alone man. The specific epigenetic mechanisms active in the small apian genome make bees potential model objects for epigenetic analyses and experiments aiming at providing solutions to such human health problems as neoplastic, genetic, metabolic, vascular, neurological and immunological diseases.
Wydawca
-
Rocznik
Tom
68
Numer
07
Opis fizyczny
s.391-396,bibliogr.
Twórcy
  • Katedra Biologicznych Podstaw Produkcji Zwierzęcej, Wydział Biologii i Hodowli Zwierząt, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 13, 20-950 Lublin
autor
autor
autor
autor
Bibliografia
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  • 20.Kucharski R., Maleszka R.: Molecular profiling of behavioural development: differential expression of mRNAs for inositol 1,4,5-trisphosphate 3-kinase isoforms in naïve and experienced honeybees (Apis mellifera). Mol. Brain Res. 2002, 99, 92-101.
  • 21.Kucharski R., Mitri C., Grau Y., Maleszka R.: Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implication for memory formation. Invert. Neurosci. 2007, 7, 99-108.
  • 22.Lipiński Z.: Istota oraz mechanizm porzucania gniazd przez roje pszczół miodnych. Blenam, Olsztyn 2002.
  • 23.Lockett G., Helliwell P., Maleszka R.: Involvement of DNA methylation in memory processing in the honey bee. Learning Memory 2010, 21, 812-816.
  • 24.Lockett G., Kucharski R., Maleszka R.: DNA methylation changes elicited by social stimuli in the brains of worker honey bees. Genes, Brain and Behavior 2011, doi:10.1111/j.1601-183X.2011.00751.x.
  • 25.Lockett G., Wilkes F., Maleszka R.: Brain plasticity, memory and neurological disorders: an epigenetic perspective. Neuro Report 2010, 21, 909-913.
  • 26.Lyko F., Foret S., Kucharski R., Wolf S., Falckenhayn C., Maleszka R.: The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers. PlosBiology 2010, 8, 1-12.
  • 27.Lyko F., Maleszka R.: Insects as innovative models for functional studies of DNA methylation. Trends Genetics 2011, 27, 127-164.
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  • 33.Paleolog J., Strachecka A., Burzyñski S., Olszewski K., Borsuk G.: The larval diet supplemented with the low-molecular epigenetic switch sodium phenylacetylglutaminate influences the worker cuticle proteolytic system in Apis mellifera L. J. Apic. Sci. 2011, 55, 73-83.
  • 34.Robertson H., Gordon K.: Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera. Genome Res. 2006, 16, 1345-1351.
  • 35.Shemesh Y., Cohen M., Bloch G.: Natural plasticity in circadian rhythms is mediated by reorganization in the molecular clockwork in honeybees. FASEB J. 2007, 21, 2304-2311.
  • 36.Si A., Helliwell P., Maleszka R.: Effect of NMDA receptors antagonists on olfactory learning and memory in the honeybee (Apis mellifera). Pharmacol. Biochem. Behav. 2004, 77, 191-197.
  • 37.Si A., Zhang S., Maleszka R.: Effect of caffeine on olfactory and visual learning in the honey bee (Apis mellifera). Pharmacol. Biochem. Behav. 2005, 82, 664-672.
  • 38.Tautz J.: Fenomen pszczół miodnych. Galaktyka, Łódź 2008.
  • 39.The Honeybee Genome Sequencing Consortium: Insight into social insects from the genome of the honeybee Apis mellifera. Nature 2006, 443, 931-949.
  • 40.Wang Y., Jorda M., Maleszka R., Ling X., Robertson H., Mizzen C., Peinado M., Robinson G.: Functional CpG methylation system in a social insect. Science 2006, 314, 645-647.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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