The possible protective effect of L-arginine against 5-fluorouracil-induced nephrotoxicity in male albino rats

• Autorzy: Badawoud M.H. , Elshal E.B. , Zaki A.I. , Amin H.A.
• Języki publikacji: EN

Abstrakty

EN

5-fluorouracil (5-FU) is a potent antineoplastic agent used for the treatment of various malignancies. The L-arginine nitric oxide (NO) pathway involved in the pathogenesis of chemotherapy induced kidney damage. This work investigated the beneficial mechanism of L-arginine supplementation in 5-FU induced nephropathy. Eighty male Wistar rats were divided into four equal groups: control group; L-arginine group (378 mg/rat/day for 4 weeks); 5-FU group (189 mg/rat/week for 4 weeks) and L-arginine for 1 week before and 4 weeks concomitant with 5-FU group. At the end of experiment, the kidney functions were assessed and kidneys specimens were processed for paraffin sections and stained with haematoxylin and eosin (H&E), Masson’s trichome (MT) and periodic acid-Schiff (PAS) stains. Other sections were processed for immunohistochemical demonstration of caspase-3 and inducible NO synthase (iNOS). Image analyser was used to analyse the results morphometrically and statistically. L-arginine administration to 5-FU treated animals elicited significant reduction in serum urea and creatinine levels, urine volume, urinary protein excretion and kidney/body weight ratio in comparison to fluorouracil treated group. L-arginine improved glomeruloscelerosis, degeneration of convoluted tubules and interstitial fibrosis in 5-FU treated animals. L-arginine attenuated effectively some biochemical and histological changes in 5-FU nephrotoxicity. (Folia Morphol 2017; 76, 4: 608–619)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2017
• Tom: 76
• Numer: 4
• Opis fizyczny: p.608-619,fig.,ref.

Twórcy

autor

Badawoud M.H.

• Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

autor

Elshal E.B.

• Department of Anatomy, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

autor

Zaki A.I.

• Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
• Department of Anatomy, Faculty of Medicine, Alexandria University, Egypt

autor

Amin H.A.

• Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
• Department of Histology, Faculty of Medicine, Cairo University, Egypt

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Identyfikatory

DOI

10.5603/FM.a2017.0037