Effect of dexpanthenol on colonic anastomosis healing in rats

• Autorzy: Ermutlu C.S. , Erkilic E.E. , Kilic E. , Kirmizigul A.H. , Dag S. , Ogun M. , Baran V. , Merhan O.
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was to perform the clinical, histopathologic and biochemical evaluation of the effects of intraperitoneally (IP) administered dexpanthenol (dxp) on colonic anastomosis healing in rats. The study was conducted on a total of 28 rats divided into four groups comprising seven rats each. Group I was designated as the control group, group II as the dxp group, group III as the anastomosis group, and group IV as the anastomosis + dxp group. The groups were compared in terms of intestinal bursting pressure, adhesion formation, nitric oxide (NO) and malondialdehyde (MDA) levels, total antioxidant capacity (TAC) and total oxidant capacity (TOC) in blood and intestinal homogenates, as well as histopathologic findings. Dxp decreased adhesion formation (6 rats in group III and 4 rats in group IV). Mean bursting pressures were higher in the dxp groups than in the other groups (group II = 254.3 ± 42.1 mmHg, group IV = 109.3 ± 34.5 mmHg). Moreover, there was a remarkable decrease in the levels of NO and MDA and in blood oxidative stress parameters in the dxp groups. The results suggest that dxp increased intestinal bursting pressure by accelerating healing in the anastomosis line and decreased adhesion formation, positively affecting healing. Dexpanthenol, which was found to have positive effects in the experimental rat model, can be introduced into clinical practice.

Słowa kluczowe

EN

rat; colonic anastomosis; anastomosis; dexpanthenol; drug effect; healing

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2018
• Tom: 74
• Numer: 11
• Opis fizyczny: p.702-707,fig.,ref.

Twórcy

autor

Ermutlu C.S.

• Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Erkilic E.E.

• Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Kilic E.

• Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Kirmizigul A.H.

• Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Dag S.

• Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Ogun M.

• Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Baran V.

• Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

autor

Merhan O.

• Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey

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Identyfikatory

DOI

10.21521/mw.6135