Glucocorticoid receptor stimulation modulates morphine addiction-like symptoms

• Autorzy: Marut L. , Skupio U. , Przewlocki R.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: Morphine is widely used painkiller, however misuse of morphine may lead to the addiction. Stress system and glucocorticoids are thought to be involved in various aspects of addiction-like behavior. In animal models stressors and glucocorticoids facilitate acquisition of drug self-administration, increase their rewarding potential and promote relapse. AIM(S): The involvement of stress system in addiction is widely studied however the specific role of glucocorticoid receptor (GR) is still not fully understood. The aim of this study was to evaluate effects of GR stimulation on addiction-like symptoms induced by morphine. METHOD(S): We used dexamethasone (DEX), selective glucocorticoid receptor agonist, in self-administration (SA) and conditioned place preference (CPP) paradigms in mice. Mice were allowed to self-administer increasing doses of morphine. To test the influence of GR stimulation on morphine intake, we administered DEX (4 mg/kg). Also effects of DEX on morphine place preference was evaluated. 1 hour before morphine conditioning mice were pretreated with either DEX (4 mg/kg) or saline (SAL). RESULTS: DEX treatment resulted in significant increase in morphine intake. This effect seems to be specific for the drug, as at the same time, DEX treatment caused decrease in water intake. Interestingly, in CPP paradigm DEX pretreatment resulted in significant decrease of time spent in morphine-paired compartment of the apparatus. In control conditions SAL pretreatment did not affect morphine place preference. CONCLUSIONS: In CPP paradigm DEX attenuate morphine place preference that is a measure of drug rewarding properties. GR stimulation led to enhanced morphine SA. This result may indicate that after DEX mice need more drug to achieve the same reward. Taking together our result may suggest that GR stimulation decrease rewarding potential of morphine. FINANCIAL SUPPORT: Funding for this study was provided by Polish National Science Centre Grants: 2013/08/A/ NZ3/00848.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.66

Twórcy

autor

Marut L.

• Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, Cracow, Poland

autor

Skupio U.

• Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, Cracow, Poland

autor

Przewlocki R.

• Institute of Pharmacology Polish Academy of Sciences, Department of Molecular Neuropharmacology, Cracow, Poland