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1988 | 39 | 5-6 |

Tytuł artykułu

Metabolic response to starvation in late pregnant rats. II. Fetal response

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EN

Abstrakty

EN
Nowacka, M. and Górski, J.: Metabolic response to starvation in late pregnant rats. II. Fetal response. Acta (physiol. Pol., 1988, 39 (5-6): 435-441. Effect of prolonged maternal fasting on the fetal liver and heart glycogen and triglyceride content and on concentration of glucose, urea, uric acid and alpha amino-nitrogen in the amniotic fluid has been studied in rats. The animals were divided into four groups: fed (control), fasted for one day (from 20 to 21 day of pregnancy), fasted for two days (from 19 to 21 day) and fasted for three days (from 18 to 21 day). Maternal fasting for two and three days resulted.in reduction in fetal growth. The fetal liver glycogen content was reduced already alter one day of fasting, stabilized after two days and then further decreased alter three days. The fetal heart glycogen content was reduced only after three days of fasting. The fetal liver triglyceride content increased gradually during the first two days of fasting and then stabilized. The content of triglycerides in the heart was elevated after two and three days of food deprivation. The amniotic fluid glucose concentration decreased after one day of fasting and then stabilized. Fasting did not effect the concentration of the nitrogenous compounds in the amniotic fluid. It is concluded that maternal fasting affects markedly metabolism of energy substrates stored in the fetal liver and the heart and the composition of the amniotic fluid.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

39

Numer

5-6

Opis fizyczny

p.435-441,ref.

Twórcy

autor
  • Department of Clinical Physiology and Department of Physiology, School of Medicine, Bialystok, Poland
autor
  • Department of Clinical Physiology and Department of Physiology, School of Medicine, Bialystok, Poland

Bibliografia

  • 1. Adalovic, N.. Rukavina, D., Eberhardt, P. (1970) Hormonal aspects of glycogen accumulation in fetal and neonatal rat liver. Proc. Soc. Expll. Biol. Med. 134. 943- 946.
  • 2. Battaglia, F.C., Meschia, G. (1981) Foetal and placental metabolisms: their interrelationship and impact upon maternal metabolism. Fed. Proc. 40. 99-'113.
  • 3. Beaton, G.H., Beare, J., Ryn, M.H., McHenry, E.W. (1954) Protein metabolism in the pregnant rats. J. Nutr. 54 . 291-306.
  • 4. Bossi, E., Greenberg, R.E. (1972) Sources of blood glucose in the rat fetus. Pediat. Res. 6. 763-772.
  • 5. Coleman, R.A. (1986) Placental metabolism and transport of lipid. Fed. Proc. 45. 2519-2523.
  • 6. Felig, P., Kim, Y.J., Lynch, V., Hendler R. (1972) Amino acid metabolism during starvation in human .pregnancy. J. Clin. Invest. 51. 1195-1202.
  • 7. Freinkel, N., Metagdr, B., Herrera, E., Aignolli, F., Knopp, R.H. (1974) The effects of pregnancy on metabolic fuels. In: Proceedings ot the VII Congress oi the International Diabetes Fedration. pp. 656-666. Excerpta Medica, International Congress Series (no. 231), Amsterdam.
  • 8. Freinkel, N. (1980) Of pregnancy and progeny. Diabetes 29. 1023-1036.
  • 9. Freund, N., Kervran, A., Assan, R., Geloso, J.P., Girard, J. (1980) Fetal metabolic response to phloridain induced hypoglycemia in pregnant rats. Biol. Neonate 38. 321-327.
  • 10. Gilbert. M. Bourbon, J. (1980) Effect of acute variation of fetal glycemia on glycogen storage and on glycogen synthase and phosphorylase activities in the liver of the rat fetus. Diabetes 29. 266-271.
  • 11. Girard, J.R., Ferre, P., Gilbert, M., Kervran, A., Assan, R., Marliss, E.B. (1977) Fetal metabolic response to maternal fasting in the rat. Amer. J. Physiol. Endocrinol. Metab. Gastrointest. Physiol. 1. E456-E463.
  • 12. Goodner, C:J., Thompson, D.J. (1967) Qlucoise metabolism in the fetus in utero. The effect of maternal fasting and glucose loading in the rat. Pediat. Res. 1. 443-4SI.
  • 13. Górski, J., Kiryluk, T. (1982) Effect of exercise on substrate metabolism in pregnant mother, placenta and fetal liver of the rat. In: Metabolic and Functional Changes durirtg Exercise. Ed. Tućek and Semliginovsky, pp. 129-132, Universitas Carolina Pragensis.
  • 14. Górski, J. (1983) Effect of exercise on metabolism of energy substrates in pregnant mother and her fetus in the rat. In: Biochemistry oi Exercise. Eds. H.G. Knuttgen, J.A. Vogel, J. Poortmans, pp. 229-233, Human Kinetics Publishers, Inc, Champaign, ILL.
  • 15. Herrera, E., Knopp, R.H., Freinkel, N. (1969) Carbohydrate metabolism in pregnancy. VI. Plasma fules, insulin, liver composition, gluconeogenesis, and nitrogen metabolisan during late gestation in the fed and fasted rat. J. Clin. Invest. 48. 2260-2272.
  • 16. Higham, F.C., Pillay, D., Bailey, E. (1984) The effect of matertial diet on fetal hepatic and brain adipose tissue lipogenesis and blood and tissue metabolites. J. Develop. Physiol. 6. 153-158.
  • 17. Kim, Y.K.K., Felig, P. (1972) Maternal and amniotic fluid substrate levels during caloric deprivation in human pregnancy. Metabolism 21. 507-512.
  • 18. Klepać, R., Jacquot, R., Kretchmer, N. (1964) Effect of fetal decapitation on enzymes of glycogen metabolism. J. Biol. Chem. 239. 1301-1304.
  • 19. Lasuncion, M.A., Lorenzo, J., Palacin, M., Herrera, E. (1987) Maternal factors modulating nutrient transfer to fetus. Biol. Neonate 51. 86-93.
  • 20. Lorenzo, M., Benito, M., Caldes, T., Medina, J.M. (1983) Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and fetal tissues during late gestation in the rat. Biochem. J. 216. 695-699.
  • 21. Maickel, R.P., Brodie, B.B. (1963) Interaction of drugs with the pituitary-adrenocortical system in the production of the fatty liver. Ann. N.Y. Acad. Sci. 104. 1059- 1064.
  • 22. Nowacka, M., Górski, J. (1988) Metabolic response to starvation in late pregnant rats. I. Maternal response. Acta Physiol. Pol. (submitted for publication).
  • 23. Schreiner, R.L., Lemons, J.A., Gresham, E.L. (1981) Metabolic and hormonal response to chronic maternal fasting in the ewe. Ann. Nutr. Nletab. 25. 38-47.
  • 24. Shelley, H.J. (1961) Glycogen reserves and their changes at birth. Brit. Med. Bull. 17. 137-143.
  • 25. Simmons, M.A., Meschia, G., Makowski, E.L., Battaglia, F.C. (1974) Fetal metabolic response to maternal starvation. Pediat. Res. 8. 830-836.
  • 26. Vinicor, F., Kohalmi, D., Clark, Ch.M., Jr. (1974) Characterization of carbohydrate metabolism in the isolated fetal rat heart. Effects of fasting and alloxan diabetes. Diabetes 23. 662-668.

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Bibliografia

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