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1989 | 40 | 5-6 |
Tytuł artykułu

Catecholamines in the rat brain during hypoglycemic convulsions and coma

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Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Losy J. and Bernat R.: Catecholamines in the rat brain during hypoglycemic convulsions and coma. Acta physiol, pol. 1989,40 (5-6): 479-485. The purpose of the study was to investigate the relation between the catecholamines: noradrenaline and dopamine in the rat brain on one hand and hypoglycemic convulsions and coma on the other. Concentrations of naradrenaline in the hypothalamus, brain stem and cerebral cortex were decreased during hypoglycemic convulsions and were lower during coma than those during convulsions. Dopamine concentration in the striatum was decreased during convulsions and coma. It was shown that the decrease in concentration of catecholamines was a result of hypoglycemia but not of insulin action itself. Clonidine-α₂ agonist accelerated occurrence and prolonged duration of hypoglycemic convulsions. Haloperidol-dopamine receptor blocker had no effect on the time of occurrence or duration of convulsions and coma. The results indicate that noradrenaline may exert an inhibitory influence on hypoglycemic convulsions, No evidence has been provided to support involvement of dopamine in the control of hypoglycemic convulsions and coma.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.479-485,ref.
Twórcy
autor
  • Laboratory of Nervous System and Sensory Organs, Department of Physiology, School of Medicine, Poznan, Poland
autor
  • Laboratory of Nervous System and Sensory Organs, Department of Physiology, School of Medicine, Poznan, Poland
Bibliografia
  • 1. Agardh, C. D., Carlsson, A., Lindqvist, M., Siesjö, В. K. (1979) The effect of pronounced hypoglycemia on monoamine metabolism in rat brain. Diabetes 28. 804-809.
  • 2. Berggien, U., Engel, J., Litjequist, S. (1983) Differential effects of insulin on brain monoamine metabolism in rats. Acta pharmacol. Toxicol. 53. 39-43.
  • 3. Brodie, В. B., Comer, M. S., Costa, E., Diabac, A. (1966) The role of brain serotonin in the mechanism of central action of reserpine. J. Pharmacol. Exp. Ther. 152. 340-349.
  • 4. Carlson, A., Holmin, T., Lindqvist, M., Siesjö, В. K. (1977) Effect of hypercapnia and hypocapnia on tryptophan and tyrosine hydroxylation in rat brain. Acta Physiol. Scand. 99. 503-509.
  • 5. Chang, С. C. (1964) A sensitive method for spectrophotofluorometric assay of catecholamines. Int. I. Neuropharmacol. 3. 643-649.
  • 6. Davis, J. N., Carlsson, A. (1973) The effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain. J. Neurochem. 21. 783-790.
  • 7. Drew, G. M., Gower, A, Mariott, A. S. (1977) Pharmacological characterization of alpha adrenoceptors with mediate clonidine-induced sedation. Br. J. Pharmacol. 61. 468-477.
  • 8. Ferrendeli, J. A., Chang, M. M. (1973) Brain metabolism during hypoglycemia. Arch. Neurol. 28. 173-197.
  • 9. Freinkel, N., Metzger, В. E., Harris, E., Robinson, S., Meger, M. (1972) The hypothermia of hypoglycemia. Studies with 2-deoxy-D-glucose in normal human subjects and mice. N. E. J. Med. 287. 841-845.
  • 10. Glowiński, J., Iversen, L. L. (1966) Regional studies of catecholamines in the rąt brain. The disposition of ³H-norepinephrine, ³H-dopamine and ³H-dopa in various regions of the rat brain. J. Neurochem. 13. 655-669.
  • 11. Jobe, P. C., Picchioni, A. L., Chin, L. (1973) Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184. 1-10.
  • 12. Lavielle, S., Tassin, J. P., Thierry, A. M., Blanc, G., Herve, D., Barthelemy, C., Glowiński, J. (1978) Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopamineric neurons of the rat. Brain Res. 168.585-594.
  • 13. Lewis, L. D., Ljunggren, B., Norberg, K., Siesjö, В. K. (1974) Changes in carbohydrate substrates, amino acids and ammonia in the brain during insulin-induced hypoglycemia. J. Neurochem. 23. 659-671.
  • 14. Mac Kenzie, R. G., Trulson, M. E. (1978) Effects of insulin and streptozotocin-induced diabetes on brain tryptophan and serotonin metabolism in rats. J. Neurochem. 30. 205-211.
  • 15. Mason, S. T., Corcoran, M. E. (1979) Catecholamines and convulsions. Brain Res. 170. 497-507.
  • 16. Molnar, G. W., Read, R. C. (1974) Hypoglycemia and body temperture. J. Amer. Med. Ass. 227.916-921.
  • 17. Norberg, K., Siesjö, В. K. (1976) Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia. J. Neurochem. 26. 345-352.
  • 18. Patric, R. L., Rendel, M. T. (1980) pH-induced alterations in dopamine synthesis regulation in rat brain striatal synaptosomes. J. Neurochem. 34. 1506-1523.
  • 19. Sauter, A., Goldstein, M., Engel, J., Ueta, K. (1983) Effect of insulin in central catecholamines. Brain Res. 260. 330-333.
  • 20. Segal, M., Bloom, F. E. (1974) The action of norepinephrine in the hippocampus. Iontophoretic studies. Brain Res. 72. 79-97.
  • 21. Stone, E. A. (1973) Accumulation and metabolism of norepinephrine in rat hypothalamus after exhaustive stress. J. Neurochem. 21.589-601.
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Bibliografia
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