Efficacy and safety of artesuante-amodiaquine and artemether lumefantrine, the first line malaria treatment in six sentinel’s sites of Côte d’Ivoire, West Africa

• Autorzy: Toure O.A. , Assi S.B. , Kiki-Barro P.M.C. , Yavo W. , Abba T. , Tiacoh L.N. , Konate A.A. , Angora E.K. , Bedia V.A. , Menan H. , Daho A.K. , Emmanuel B.
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was to update efficacy data of Artesunate-Amodiaquine (AS+AQ) and Artemether-Lumefantrine (AL) used as first-line malaria treatment in Côte d’Ivoire since 2005. This was an open-label, randomized trial conducted in patients older than 6 months with uncomplicated P. falciparum malaria at six sentinel sites. The WHO 2009 protocol on surveillance of anti-malaria drug efficacy was used with primary outcomes as ACPR corrected by PCR at day 42. Secondary endpoints were parasite and fever clearance times and safety. From January to July 2016, 712 patients were included in the trial. 353 and 359 patients were randomly assigned respectively to the AS+AQ and AL arm. Day 42 PCR-adjusted ACPR in the per-protocol analysis was 99.4% and 98.8% in AS+AQ and AL arm respectively. Delayed parasite clearance was observed in six patients at Abidjan and Yamousssoukro sites. Both ACTs were well tolerated. Both ACTs remain efficacious for uncomplicated P. falciparum malaria treatment in Côte d’Ivoire. But regarding delayed parasite clearance observed in this study, a close monitoring and supervision for ACT resistance are essential for future malaria treatment and control strategies in Côte d′Ivoire.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2020
• Tom: 66
• Numer: 4
• Opis fizyczny: p.561-571,fig.,ref.

Twórcy

autor

Toure O.A.

• Malariology Department, Institut Pasteur of Cote d’Ivoire, Boulevard Universite, Abidjan 01, Cote d’Ivoire

autor

Assi S.B.

• Malariology Department, Institut Pasteur of Cote d’Ivoire, Boulevard Universite, Abidjan 01, Cote d’Ivoire

autor

Kiki-Barro P.M.C.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Yavo W.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Abba T.

• Infectious and Tropical Diseases Unit, Medical Science Training and Research, Allassane Ouattara University, Rue Universite, Bouake 1801, Cote d’Ivoire

autor

Tiacoh L.N.

• Malariology Department, Institut Pasteur of Cote d’Ivoire, Boulevard Universite, Abidjan 01, Cote d’Ivoire

autor

Konate A.A.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Angora E.K.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Bedia V.A.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Menan H.

• Parasitology and Mycology Department, Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University, Boulevard Universite, Abidjan V34, Cote d’Ivoire

autor

Daho A.K.

• Parasitology and Mycology Department, Medical Science Training and Research, Allassane Ouattara University, Rue Universite, Bouake 1801, Cote d’Ivoire

autor

Emmanuel B.

• Scientific Advisory Board of National Malaria Control Program, Cote d’Ivoire, Riviera Palmeraie, Cite Syninfo V4 Abiajan, Cote d’Ivoire

Identyfikatory

DOI

10.17420/ap6604.299