The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study

• Autorzy: Maden M. , Yildiz R. , Col R. , Arican M. , Ider M. , Parlak K. , Tras B.
• Języki publikacji: EN

Abstrakty

EN

This study aimed to assess the clinical efficacy of pentoxifylline (PTX) and L-glutamine (L-Gln) treatment on ischemia and reperfusion (I/R) injury in the abomasal tissue, acute phase response (APR), oxidative stress (OS), cytokine response, hemostatic, and coagulation disorders in the 96-h period before and after surgery in displaced abomasum (DA) cases. The study sample consisted of 48 dairy cows with DA that were categorized into four groups as group S (Sham group) (9 Left displaced abomasum (LDA)+3 Right displaced abomasum (RDA), group P (PTX) (10 LDA+2 RDA), group G (L-Gln) (10 LDA+2 RDA), and group P+G (PTX+L-Gln) (10 LDA+2 RDA). Acute-phase protein (Haptoglobin), oxidative stress indicators (malondialdehyde, nitric oxide, and glutathione), cytokines (tumor necrosis factor (TNF)-α and interleukin-1β (IL-1β), coagulation factors (D-Dimer, Antithrombin (ATIII), Thrombin-antithrombin complex, Plasminogen activator inhibitor-1), and enzyme activities (lactate dehydrogenase, gamma-glutamyl transferase, sorbitol dehydrogenase, glutamate dehydrogenase, adenosine deaminase, myeloperoxidase, and creatine phosphokinase) in blood serum samples and coagulometric analyses of blood plasma were performed in samples taken before the operation and at 30 and 60 min and 2, 5, 10, 24, 48, 72, and 96 h after the operation. In DA cases, while post-operative treatment procedures with PTX and L-Gln were effective in decreasing APR and OS, these were ineffective in prohibiting the inflammatory response coordinated by cytokines. For the treatment and prevention of I/R injury in the DA cases, PTX and L-Gln procedures hold promise with their effects on APR, OS, and hemostatic dysfunction. Additional treatment procedures are required for the suppression of inflammatory response, and the effectiveness of preconditioning treatment may be evaluated.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2021
• Tom: 24
• Numer: 4
• Opis fizyczny: p.595-605,ref.

Twórcy

autor

Maden M.

• Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

autor

Yildiz R.

• Department of Internal Medicine, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, 15030, Burdur, Turkey

autor

Col R.

• Department of Physiology, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

autor

Arican M.

• Department of Surgery, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

autor

Ider M.

• Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

autor

Parlak K.

• Department of Surgery, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

autor

Tras B.

• Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey

Identyfikatory

DOI

10.24425/pjvs.2021.139985