Functional aspects of eicosanoid metabolism

• Autorzy: Carroll M.A. , McGiff J. C.
• Języki publikacji: EN

Abstrakty

EN

The sequential metabolism of eicosanoids by AA oxygenases confers biological properties that may have significant functional implications. Further- the interpretation of the effects of cyclooxygenase inhibitors on eicosanoid, dependent mechanisms needs to be reevaluated. Previously, if cyclooxygenase inhibitors affected the biological action of AA, it was considered to be due to elimination of a prostanoid-mediated component. This interpretation is no longer valid if a cell or tissue has significant P450 and cyclooxygenase activity. The cellular proximity of the P450-dependent monooxygenases and cyclooxygenase, described in tubules, interstitial cells, and blood vessels, may confer a unique ability of A A metabolites to coordinate tubular and vascular function.

Słowa kluczowe

EN

arachidonic acid; cytochrome P450; cyclooxygenase; eicosanoid; prostaglandin; monooxygenase; blood vessel; functional aspect

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1991
• Tom: 42
• Numer: 3
• Opis fizyczny: p.251-261,fig.,ref.

Twórcy

autor

Carroll M.A.

• Department of Pharmacology, New York Medical College Valhalla, New York 10595, USA

autor

McGiff J. C.

• Department of Pharmacology, New York Medical College Valhalla, New York 10595, USA

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