The oxidative status of milking goats after per os administration of N-acetylcysteine

• Autorzy: Jozwik A. , Bagnicka E. , Strzalkowska N. , Sliwa-Jozwik A. , Horbanczuk K. , Cooper R. G. , Pyzel B. , Krzyzewski J. , Swiergiel A. H. , Horbanczuk J. O.

Warianty tytułu

PL

Status oksydacyjny kóz dojnych po doustnym podawaniu N-acetylocysteiny

• Języki publikacji: EN

Abstrakty

EN

Investigated were changes in selected redox parameters – vitamin C, malondialdehyde (MDA) and glutathione (GSH) content of goat blood plasma – as markers of oxidative stress after per os administration the N-acetylcysteine (NAC). Used were 20 Polish White Improved goats, selected from the flock of 60 animals. Within the selected goats distinguished were four groups according to somatic cell counts (SCC) of milk: group I – below 1×106, group II – 1×106-2×106, group III – 2×106-4×106 and group IV – above 4×106/ml. Concentrations of GSH, MDA and vitamin C of blond plasma were assessed just at start of the experiment and then after 7 days of daily administration of 12 mg NAC per kg body weight to goats. After 7 days of administering NAC to goats the plasma concentration of both MDA and GSH dropped and that of vitamin C increased. It is concluded that NAC administered per os increases the anti-oxidant capacity and may reduce the content of lipid peroxidation products in blood plasma of milking goats.

PL

Badano zachowanie się wybranych parametrów redox – zawartości witaminy C w surowicy, malonodwualdehydu (MDA) w osoczu i glutationu (GSH) w pełnej krwi kóz dojnych – jako wskaźników stresu oksydacyjnego po 7 dniach doustnego podawania N-acetylocysteiny (NAC). Użyto 20 kóz rasy polskiej białej uszlachetnionej ze stada liczącego 60 zwierząt. Wybrane kozy podzielono na 4 grupy,zależnie od liczby komórek somatycznych (SCC) w mleku (grupa I – poniżej 1×106, grupa II – 1×106-2×106, grupa III – 2×106-4x106 i grupa IV – ponad 4106/ml. Poziom witaminy C, MDA i GSH we krwi oznaczono jednorazowo na początku badań (dzień 0), a następnie, także jednorazowo, po 7 dniach, w ciągu których codziennie podawano zwierzętom doustnie NAC. Postępowanie takie doprowadziło do spadku poziomu MDA w osoczu i GSH w pełnej krwi oraz wzrostu poziomu witaminy C w surowicy krwi. Autorzy wnioskują, że NAC podawana per os zwiększa antyoksydacyjną wydajność organizmu i może ograniczać zawartość produktów peroksydacji lipidów w osoczu.

Słowa kluczowe

EN

oxidative status; milking goat; goat; administration; N-acetylcysteine; glutathione; lipid peroxidation; malondialdehyde; oxidative stress; vitamin C

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2010
• Tom: 28
• Numer: 2
• Opis fizyczny: p.143-152,fig.,ref.

Twórcy

autor

Jozwik A.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Wolka Kosowska, Poland

autor

Bagnicka E.

autor

Strzalkowska N.

autor

Sliwa-Jozwik A.

autor

Horbanczuk K.

autor

Cooper R. G.

autor

Pyzel B.

autor

Krzyzewski J.

autor

Swiergiel A. H.

autor

Horbanczuk J. O.

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