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2019 | 79 | Suppl.1 |

Tytuł artykułu

The effect of transcutaneous stimulation of the vagus nerve on hippocampal formation theta rhythm in anaesthetized rats

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
INTRODUCTION: A number of invasive and noninvasive brain‑stimulation techniques are used in clinical neurology. Stimulation of peripheral nerves may affect brain activity through a bottom-up mechanism, for instance, by stimulating cranial nerve nuclei in the brainstem. With specific regard to peripheral methods, studies using vagal nerve stimulation (VNS) have demonstrated that neurostimulation modalities can produce robust therapeutic effects without incurring unsafe consequences on brain function. Just recently, we have demonstrated that direct VNS induced hippocampal (HPC) theta rhythms. The fact that HPC theta rhythm is directly involved in memory processing suggests that VNS can be considered as a useful treatment of patients with Alzheimer’s disease. METHOD(S): Transcutaneous stimulation of the vagus nerve (t-VNS) was performed on the level of external ear in anesthetized rats. Two uninsulated tungsten electrodes (0.1‑0.2 kΩ) were used for bipolar VNS through the left lobule of the auricle. Three different points localized on the left lobule of the auricle were tested. The following VNS intensities were applied: 0.2‑10 mA. The frequency of VNS was in range (5‑60 Hz), pulse duration (1 ms) and train duration (10 s). RESULTS: Three separate points of localized on the left lobule of the auricle responded with different HPC field responses. The most effective in inducing HPC theta rhythm was the area of entrance of the external auditory canal. CONCLUSIONS: The data obtained in the project indicated that the entrance of external auditory canal was found to be the most effective in inducing theta rhythm during t‑VNS. Further, the effectiveness of t‑VNS on HPC theta rhythm is determined by its intensity and local density of vagal endings. FINANCIAL SUPPORT: These studies were supported by The National Centre of Research and Development (grant no 01.02.00‑00‑0023/17‑001).

Słowa kluczowe

Wydawca

-

Rocznik

Tom

79

Numer

Opis fizyczny

p.XLVIII

Twórcy

autor
  • Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
autor
  • Medical Technology Center, Research Department, Natolin, Poland
autor
  • Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
  • Medical Technology Center, Research Department, Natolin, Poland

Bibliografia

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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