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2010 | 70 | 1 |
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Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep

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Suckling induces a GH surge simultaneously to that of prolactin, so we tested whether salsolinol, a dopamine derivative (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), participates in the regulatory process of GH secretion in lactating sheep. A series of intracerebroventricular (i.c.v.) infusions of salsolinol, in two doses, was performed in nursing sheep, without suckling, during the fifth week of lactation. In other suckling sheep, we infused i.c.v. a structural analogue of salsolinol – 1-methyl-3,4-dihydroisoqinoline (1-MeDIQ), which is able to antagonize salsolinol’s action. Intracerebroventricular treatment of nursing sheep with a lower dose of salsolinol (total 50 ng) significantly increased plasma GH concentration, as compared with the concentrations noted before the infusion and in nursing controls. A higher dose of salsolinol (total 5 μg) did not affect GH release significantly. Intracerebroventricular treatment with 1-MeDIQ (total 300 μg) significantly reduced basal GH release, not affecting a pattern of GH surge in response to suckling. In conclusion, salsolinol may affect the regulatory process of GH secretion in lactating sheep, but its role seems not to be major.
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  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
  • Department of Swine and Small Ruminant Breeding, Agricultural University in Krakow, Krakow, Poland
  • Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary
  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
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