PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 70 | 1 |
Tytuł artykułu

Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Suckling induces a GH surge simultaneously to that of prolactin, so we tested whether salsolinol, a dopamine derivative (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), participates in the regulatory process of GH secretion in lactating sheep. A series of intracerebroventricular (i.c.v.) infusions of salsolinol, in two doses, was performed in nursing sheep, without suckling, during the fifth week of lactation. In other suckling sheep, we infused i.c.v. a structural analogue of salsolinol – 1-methyl-3,4-dihydroisoqinoline (1-MeDIQ), which is able to antagonize salsolinol’s action. Intracerebroventricular treatment of nursing sheep with a lower dose of salsolinol (total 50 ng) significantly increased plasma GH concentration, as compared with the concentrations noted before the infusion and in nursing controls. A higher dose of salsolinol (total 5 μg) did not affect GH release significantly. Intracerebroventricular treatment with 1-MeDIQ (total 300 μg) significantly reduced basal GH release, not affecting a pattern of GH surge in response to suckling. In conclusion, salsolinol may affect the regulatory process of GH secretion in lactating sheep, but its role seems not to be major.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
70
Numer
1
Opis fizyczny
p.20-27,fig.,ref.
Twórcy
autor
  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
autor
  • Department of Swine and Small Ruminant Breeding, Agricultural University in Krakow, Krakow, Poland
autor
  • Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary
autor
  • Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna n/Warsaw, Poland
Bibliografia
  • Anderson GM, Beijer P, Bang AS, Fenwick MA, Bunn SJ, Grattan DR (2006) Suppression of prolactin-induced STAT5b signaling and induction of SOCS mRNA in the hypothalamic arcuate nucleus of the rat during late preg­nancy and lactation. Endocrinology 147: 4996-5005.
  • Antkiewicz-Michaluk L (2002) Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquino- lines. Pol J Pharm 54: 567-572.
  • Arbogast LA, Voogt JL (1996) The responsiveness of tuberoinfundibular dopaminergic neurons to prolactin feedback is diminished between early lactation and mid- lactation in the rat. Endocrinology 137: 47-54.
  • Armstrong JD, Esbenshade KL, Coffey MT, Heimer E, Campbell R, Mowles T, Felix A (1990) Opioid control of growth hormone in the suckled sow is primarily mediated through growth hormone releasing factor. Domest Anim Endocrinol 7: 191-198.
  • Bodnar I, Mravec B, Kubovcakova L, Toth EB, Fulop F, Fekete MIK (2004a) Stress-, as well as suckling-induced prolactin (PRL) response is blocked by a structural ana­logue of the putative hypophyseotrofic PRL-releasing factor, salsolinol (SAL). J Neuroendocrinol 16: 208­213.
  • Bodnar I, Mravec B, Kubovcakova L, Fekete MI, Nagy GM, Kvetnansky R (2004b) Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (salsolinol) administration. Ann N Y Acad Sci 1018: 124-130.
  • Dvorak P, Becka S, Krejci P, Chrpova M (1978) Radioimmunoassay of bovine growth hormone. Biochem Radioanal Lett 34: 160-166.
  • Escalada J, Sanchez-Franco F, Velasco B, Cacicedo L (1997) Regulation of growth hormone (GH) gene expression and secretion during pregnancy and lactation in the rat: role of insulin-like growth factor-I, somatostatin, and GH-releasing hormone. Endocrinology 138: 3435-3443.
  • Gorski K, Romanowicz K, Herman A, Molik E, Gajewska A, Tomaszewska-Zaremba D, Misztal T (2009) The pos­sible involvement of salsolinol and hypothalamic prolactin in the central regulatory processes in ewes during lactation. Reprod Domest Anim [Epub ahead of print] doi: 10.1111/j.1439-0531.2009.01521.x
  • Grosvenor CE, Krulich L, Mccann SM (1968) Depletion of pituitary concentration of growth hormone as a result of suckling in the lactating rat. Endocrinology 82: 617-619.
  • Hashizume T, Nonaka S, Yonezawa C, Yamashita T, Kasuya E, Sutoh M, Olah M, Szekacs D, Nagy GM (2008) Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants. Domest Anim Endorinol 34: 146-152.
  • Hashizume T, Onodera Y, Shida R, Isobe E, Suzuki S, Sawai K, Kasuya E, Nagy GM (2009) Characteristics of prolactin-releasing response to salsolinol (SAL) and thyrotropin-releasing hormone (TRH) in ruminants. Domest Anim Endocrinol 36: 99-104.
  • Homicsko KG, Kertesz I, Randai B, Toth BE, Toth G, Fulop F, Fekete MI, Nagy GM (2003) Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat. Neurochem Internat 42: 19-26.
  • Iqbal J, Manley TR, Yue Q, Namavar MR, and Clarke IJ (2005) Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep. J Neuroendocrinol 17: 341-352.
  • Kelly PA, Bachelot A, Kedzia C, Hennighausen L, Ormandy CJ, Kopchick JJ, Binart N (2002) The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol 197: 127-131.
  • Kheradpezhouh M, Shavali S, Ebadi M (2003) Salsolinol causing parkinsonism activates endoplasmic reticulum- stress signaling pathways in human dopaminergic SK-N- SH cells. Neurosignals 12: 315-324.
  • Malozowski S, Hao EH, Ren SG, Genazzani AD, Kalogeras KT, Merriam GR (1990) Effects of inhibition of norepi­nephrine synthesis on spontaneous and growth hormone- releasing hormone-induced GH secretion in cynomolgus macaques: evidence for increased hypothalamic soma- tostatin tone. Neuroendocrinology 51: 455-458.
  • McMahon CD, Radcliff RP, Lookingland KJ, Tucker HA (2001a) Neuroregulation of growth hormone secretion in domestic animals. Domest Anim Endocrinol 20: 65-87.
  • McMahon CD, Chapin LT, Radcliff RP, Lookingland KJ, Tucker HA (2001b) Somatostatin inhibits alpha-2-adren- ergic-induced secretion of growth hormone-releasing hormone. Neuroendocrinology 73: 417-425.
  • Misztal T, Gorski K, Tomaszewska-Zaremba D, Molik E, Romanowicz K (2008) Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its rela­tion to suckling-induced prolactin and growth hormone 425 release. J Endocrinol 198: 83-89.
  • Misztal T, Gorski K, Tomaszewska-Zaremba D, Fulop F, Romanowicz K (2010) Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin release and dopaminergic activity in the mediobasal hypothalamus in nursing sheep. Brain Res 1307: 72-77.
  • Moser A, Scholz J, Nobbe F, Vieregge P, Bohme V, Bamberg H (1995) Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease. J Neurol Sci 131: 183-189.
  • Mravec B, Bodnar I, Fekete MI, Nagy GM, Kvetnansky R (2004) Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat. Autonom Neurosci 115: 35-40.
  • Naoi M, Maruyama W, Akao Y, Yi H (2002) Dopamine- derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease. Neurotoxicol Teratol 24: 579-591.
  • NRIAP - National Research Institute of Animal Production (1993) Nutrient requirements for cattle and sheep in the traditional system (in Polish). National Research Institute of Animal Production (Instytut Zootechniki - Państwowy Instytut Badawczy), Krakow, PL.
  • Plotsky PM, Vale W (1985) Patterns of growth hormone- releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230: 461-463.
  • Radnai B, Kandar Z, Somogyvari-Vigh A, Mergl Z, Olah M, Fulop F, Vecsernyes M, Nagy GM (2005) Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats. Brain Res Bull 65:105-110.
  • Riskind PN, Millard WJ, Martin JB (1984) Opiate modula­tion of the anterior pituitary hormone response during suckling in the rat. Endocrinology 114: 1232-1237
  • Skipor J, Thiery J-C (2008) The choroids plexus - cerebro- spinal fluid system: undervaluated pathway of neuroen­docrine signaling into the brain. Acta Neurobiol Exp (Wars) 68: 414-428.
  • Szekacs D, Bodnar I, Mravec B, Kvetnansky R, Vizi ES, Nagy GM, Fekete MI (2007a) The peripheral noradrener- gic terminal as possible site of action of salsolinol as prolactoliberin. Neurochem Internat 50: 427-434.
  • Szekacs D, Bodnar I, Vizi ES, Nagy GM, Fekete MI (2007b) The role of catecholamines in the prolactin release induced by salsolinol. Neurochem Internat 51: 319-322.
  • Tannenbaum GS, Ling N (1984) The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 115: 1952-1957.
  • Toth BE, Homicsko KG, Radnai B, Maruyama W, DeMaria JE, Vecsernyes M (2001) Salsolinol is a putative endog­enous neurointermediate lobe prolactin-releasing factor. J Neuroendocrinol 13: 1042-1050.
  • Toth BE, Bodnar I, Homicsko KG, Fulop F, Fekete MI, Nagy GM (2002). Physiological role of salsolinol: its hypophysiotrophic function in the regulation of pituitary prolactin secretion. Neurotoxicol Teratol 24: 655-656.
  • Traczyk W, Przekop F (1963) Methods of investigation of the function of the hypothalamus and hypophysis in chronic experiments in sheep. Acta Physiol Polon 14: 217-226.
  • Trott JF, Vonderhaar BK, Hovey RC (2008) Historical per­spectives of prolactin and growth hormone as mammo- gens, lactogens and galactagogues--agog for the future! J. Mammary Gland Biol Neoplasia 13: 3-11.
  • Tucker HA (2000) Symposium: hormonal regulation of milk synthesis hormones, mammary growth, and lactation: a 41-year perspective. J Dairy Sci 83: 874-884.
  • Tsagarakis S, Ge F, Rees LH, Besser GM, Grossman A (1989) Stimulation of alpha-adrenoceptors facilitates the release of growth hormone-releasing hormone from rat hypothalamus in vitro. J Neuroendocrinol 1: 129-133.
  • Wehrenberg WB, Gaillard RC (1989) Neuroendocrine mechanisms regulating growth hormone and prolactin secretion during lactation. Endocrinology 124: 64-467.
  • Wehrenberg WB, Bloch B, Ling N (1985) Pituitary secretion of growth hormone in response to opioid peptides and opiates is mediated through growth hormone-releasing factor. Neuroendocrinology 41: 13-16.
  • Welento J, Szteyn S, Milart Z (1969) Observations on the stereotaxic configuration of the hypothalamus nuclei in the sheep. Anat ANZ 124: 1-27.
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-12dc365a-cbc4-4ae2-8162-a6d7020e77fa
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.