EN
The aim of the present paper was to evaluate the anti-Leishmania activity of 3 different protocols of treatment (miltefosine plus allopurinol, difloxacin cloridrate plus metronidazole and meglumine antimoniate plus allopurinol) in 42 dogs naturally infected by L. infantum, during a 24-months parasitological and clinical follow-up. Our results suggest that, apart from miltefosine, the other two therapeutic regimens could be evaluated to treat animals with canL in medium-endemicity areas.