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2015 | 75 | Supl. |

Tytuł artykułu

Amphetamine injection into contralateral nucleus accumbens shell alters feeding evoked by stimulation of the mesolimbic system

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
BACKGROUND AND AIMS: Dopamine projections from the ventral tegmental area (VTA) – a somatodendritic region of mesolimbic system to the nucleus accumbens (particularly its shell region, AcbSh) – which constitutes its main terminal structure may play a central role in modulating affective states. In the present work, we used model of the VTA electrical stimulation-induced feeding reaction to research the role of AcbSh dopamine transmission in motivated behaviors. METHODS: In 5 rats (n=5) latency to eat was measured as a function of stimulation frequency before and after contralateral intraAcbSh injection of dopamine agonist D-amphetamine (dose 5.0 µg dissolved in 0.5 µl of water). This experimental method allowed us to distinguish between motivational vs. motor aspects of tested reaction. RESULTS: Inactivation of theAcbSh caused of itsintra injection of dopamine agonist D-amphetamine on the contralateral side (in relation to the hemisphere with VTA stimulation) affects motivational processes assessed by changes in frequency threshold for stimulation-induced feeding response. We observed increase, by more than 10% (about 13.37%), in the reaction threshold as compared with water control. Increase of the frequency threshold was accompanied by a parallel rightward shift of the function relating latency to feed to stimulation frequency, but statistical analysis of latency at the specific frequencies showed no significance (from 17.71 Hz to 81.38 Hz, P>0.05). Distilled water injected into the contralateral AcbSh (volume of the 0.5 µl), as a control group (n=5), did not cause any effect in comparison with the preinjection baseline. CONCLUSION: We conclude that the contralateral inactivation at the level of AcbSh does not impair of the behavior induced by activity of the dopaminergic cells at the level of VTA. Research was financed by the Polish National Science Centre (NCN); decision no: DEC-2013/09/D/NZ4/02499.

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-

Rocznik

Tom

75

Numer

Opis fizyczny

p.S93-S94

Twórcy

  • Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland
autor
  • Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Gdansk, Poland

Bibliografia

Typ dokumentu

Bibliografia

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