N-Substituted N-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl) guanidines - antibacterial, cytotoxic activities and some structure-activity relationships

• Autorzy: Zolnowska B. , Slawinski B.J. , Grzonek A. , Kedzia A. , Kwapisz E. , Kawiak A.
• Języki publikacji: EN

Abstrakty

EN

A series of N-substituted N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)guanidine derivatives bearing sulfonamide moiety have been screened in vitro for antibacterial activity against isolates from patients with infections of oral cavity, respiratory tract and intestinal tract. The majority of compounds exhibited good antibacterial potency. 1-[4-Chloro-5-methyl-2-(4-trifluoromethylbenzylthio)benzenesulfonyl]-3-(3-sulfamoylphenyl)guanidine (13) showed very strong activity, with MIC ≤6.2 µg/ml against eleven bacteria strains belonged to Gram-positive anaerobes and aerobes. Furthermore, compound 13 exhibited promising activity toward highly resistant microorganisms such as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It was found that Parvimonas micra, Finegoldia magna, Peptostreptococcus anaerobius, Propionibacterium acnes showed the highest susceptibility toward the investigated guanidines.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2015
• Tom: 64
• Numer: 3
• Opis fizyczny: p.299-305,fig.,ref.

Twórcy

autor

Zolnowska B.

• Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland

autor

Slawinski B.J.

• Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland

autor

Grzonek A.

• Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland

autor

Kedzia A.

• Department of Oral Microbiology, Medical University of Gdansk, Gdansk, Poland

autor

Kwapisz E.

• Department of Oral Microbiology, Medical University of Gdansk, Gdansk, Poland

autor

Kawiak A.

• Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
• Department of Human Physiology, Medical University of Gdansk, Gdansk, Poland

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