PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2020 | 80 | 1 |
Tytuł artykułu

Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Adult‑onset hypothyroidism is associated with an increase in cell atrophy of the hippocampal pyramidal neurons. Physical exercise implies diverse actions on the neural tissue that promote neuron proliferation and survival. The beneficial effects of exercise seem to be inversely linked to its intensity, so that strenuous exercise has reduced protective effects. In this study we evaluated the capacity of a moderate forced‑exercise routine to counteract the neurodegenerative effects of a hypothyroid condition induced during adulthood. Simultaneously with a chronic anti‑thyroid chemical treatment, a group of rats was forced to walk in a motorized wheel for 30 min daily five times a week. In four weeks of treatment the rats developed a plain hypothyroid condition that in non‑exercised rats was accompanied by a marked increase in the number of atrophic cells in all CA regions of the hippocampus. The forced‑exercise treatment did not counter the development of hypothyroidism and its signs, but it did prevent almost completely the associated neuronal damage in all CA regions. The forced exercise also improved the cognitive function in a spatial‑learning test. These results indicate that moderate exercise has the potential to prevent the structural and functional deficits associated with a hypothyroid condition.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
80
Numer
1
Opis fizyczny
p.47-56,fig.,ref.
Twórcy
  • Department of Physiology, ENCB, Instituto Politécnico Nacional, Mexico City, Mexico
  • Department of Physiology, ENCB, Instituto Politécnico Nacional, Mexico City, Mexico
  • Department of Physiology, ENCB, Instituto Politécnico Nacional, Mexico City, Mexico
  • Department of Physiology, ENCB, Instituto Politécnico Nacional, Mexico City, Mexico
Bibliografia
  • Almeida RD, Manadas BJ, Melo CV, Gomes JR, Mendes CS, Grãos MM, Carvalho RF, Carvalho AP, Duarte CB (2005) Neuroprotection by BDNF against glutamate‑induced apoptotic cell death is mediated by ERK and PI3‑kinase pathways. Cell Death Differ 12: 1329–1343.
  • Alva‑Sánchez C, Becerril A, Anguiano B, Aceves C, Pacheco‑Rosado J (2009a) Participation of NMDA‑glutamatergic receptors in hippocampal neuronal damage caused by adult‑onset hypothyroidism. Neurosci Lett 453: 178–181.
  • Alva‑Sánchez C, Pacheco‑Rosado J, Fregoso‑Aguilar T, Villanueva I (2012) The long‑term regulation of food intake and body weight depends on the availability of thyroid hormones in the brain. Neuro Endocrinol Lett 33: 703–708.
  • Alva‑Sanchez C, Rodriguez A, Villanueva I, Anguiano B, Aceves C, Pacheco‑Rosado J (2014) The NMDA receptor antagonist MK‑801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult‑on‑ set hypothyroidism in rat. Acta Neurobiol Exp 74: 111–117.
  • Alva‑Sánchez C, Sánchez‑Huerta K, Arroyo‑Helguera O, Anguiano B, Aceves C, Pacheco‑Rosado J (2009b) The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones. Brain Res 1271: 27–35.
  • Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA (2009) Levothyroxin restores hypothyroidism‑induced impairment of hippocampus‑dependent learning and memory: Behavioral, electrophysiological, and molecular studies. Hippocampus 19: 66–78.
  • Bárez‑López S, Montero‑Pedrazuela A, Bosch‑García D, Venero C, Guadaño‑Ferraz A (2017) Increased anxiety and fear memory in adult mice lacking type 2 deiodinase. Psychoneuroendocrinology 84: 51–60.
  • Bloise FF, Cordeiro A, Ortiga‑Carvalho TM (2018) Role of thyroid hormone in skeletal muscle physiology. J Endocrinol 236: R57‑R68.
  • Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne‑Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Gereben B, Carvalho DP, Bianco AC, Werneck de Castro JP (2016) Thyroid hormone activation by type 2 deiodinase mediates exercise‑induced peroxisome proliferator‑activated receptor‑γ coactivator‑1α expression in skeletal muscle. J Physiol 594: 5255–5269.
  • Cechetti F, Worm PV, Elsner VR, Bertoldi K, Sanches E, Ben J, Siqueira IR, Netto CA (2012) Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat. Neurobiol Learn Mem 97: 90–96.
  • Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin  M, Buée  L, Laroche S, Enderlin V (2014) PTU‑induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments. Hippocampus 24: 1381–1393.
  • Chang YJ, Hwu CM, Yeh CC, Wang PS, Wang SW (2014) Effects of subacute hypothyroidism on metabolism and growth‑related molecules. Mole‑ cules 19: 11178–11195.
  • Ciloglu F, Peker I, Pehlivan A, Karacabey K, Ilhan N, Saygin O, Ozmerdivenli R (2005) Exercise intensity and its effects on thyroid hormones. Neuro En‑ docrinol Lett 26: 830–834.
  • Cooke GE, Mullally S, Correia N, O’Mara SM, Gibney J (2014) Hippocampal volume is decreased in adults with hypothyroidism. Thyroid 24: 433–440.
  • Cooper C, Moon HY, van Praag H (2018) On the run for hippocampal plas‑ ticity. Cold Spring Harb Perspect Med 8: a029736.
  • Costall B, Jones BJ, Kelly ME, Naylor RJ, Tomkins DM (1989) Exploration of mice in a  black and white test box: validation as a  model of anxiety. Pharmacol Biochem Behav 32: 777–785.
  • Deligiannis A, Karamouzis M, Kouidi E, Mougios V, Kallaras C (1993) Plasma TSH T3, T4 and cortisol responses to swimming at varying water tem‑ peratures. Br J Sports Med 27: 247–250.
  • Eichenbaum H, Cohen NJ (2001) From Conditioning to Conscious Recollec‑ tion: Memory Systems of the Brain. Oxford Psychology Series no. 35. Oxford University Press, New York, NY.
  • Gilbert ME, Sanchez‑Huerta K, Wood C (2016) Mild thyroid hormone in‑ sufficiency during development compromises activity‑dependent neu‑ roplasticity in the hippocampus of adult male rats. Endocrinology 157: 774–787.
  • Gkikas D, Tsampoula M, Politis PK (2017) Nuclear receptors in neural stem/ progenitor cell homeostasis. Cell Mol Life Sci 74: 4097–4120.
  • Guzman‑Marin R, Suntsova N, Bashir T, Nienhuis R, Szymusiak R, McGinty D (2008) Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat. Sleep 31: 167–175.
  • Harrison FE, Reiserer RS, Tomarken AJ, McDonald MP (2006) Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem 13: 809–819.
  • Hillman CH, Erickson KI, Kramer AF (2008) Be smart, exercise your heart: Exercise effects on brain and cognition. Nat Rev Neurosci 9: 58–65.
  • Huang WS, Yu MD, Lee MS, Cheng CY, Yang SP, Chin HM, Wu SY (2004) Effect of treadmill exercise on circulating thyroid hormone measurements. Med Princ Pract 13: 15–19.
  • Khordad E, Alipour F, Beheshti F, Hosseini  M, Rajabzadeh AA, Asiaei F, Seghatoleslam  M (2018) Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study. J Chem Neuroanat 93: 48–56.
  • Kilic M (2007) Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Neuro Endocrinol Lett 28: 681–685.
  • Kim BS, Kim MY, Leem YH (2011) Hippocampal neuronal death induced by kainic acid and restraint stress is suppressed by exercise. Neuroscience 194: 291–301.
  • Klein C, Rasińska J, Empl L, Sparenberg M, Poshtiban A, Hain EG, Iggena D, Rivalan M, Winter Y, Steiner B (2016) Physical exercise counteracts MPTP‑induced changes in neural precursor cell proliferation in the hippocampus and restores spatial learning but not memory performance in the water maze. Behav Brain Res 307: 227–238.
  • Leasure JL, Jones M (2008) Forced and voluntary exercise differentially affect brain and behavior. Neuroscience 156: 456–465.
  • Madeira MD, Sousa N, Lima‑Andrade MT, Calheiros F, Cadete‑Leite A, Paula‑Barbosa MM (1992) Selective vulnerability of the hippocampal pyramidal neurons to hypothyroidism in male and female rats. J Comp Neurol 322: 501–518.
  • Marosi K, Mattson MP (2014) BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 25: 89–98.
  • Mastorakos G, Pavlatou M (2005) Exercise as a stress model and the interplay between the hypothalamus‑pituitary‑adrenal and the hypothalamus‑pituitary‑thyroid axes. Horm Metab Res 37: 577–584.
  • Montero‑Pedrazuela A, Venero C, Lavado‑Autric R, Fernández‑Lamo I, García‑Verdugo JM, Bernal J, Guadaño‑Ferraz A (2006) Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive‑like behavior. Mol Psychiatry 11: 361–371.
  • Mu Y, Gage FH (2011) Adult hippocampal neurogenesis and its role in Alz‑ heimer’s disease. Mol Neurodegener 6: 85.
  • Nam SM, Kim JW, Yoo DY, Jung HY, Chung JY, Kim DW, Hwang IK, Yoon YS (2018) Hypothyroidism increases cyclooxygenase‑2 levels and pro‑inflammatory response and decreases cell proliferation and neuroblast differentiation in the hippocampus. Mol Med Rep 17: 5782–5788.
  • Neto RA, de Souza Dos Santos MC, Rangel IF, Ribeiro MB, Cavalcanti-de-Albuquerque JP, Ferreira AC, Cameron LC, Carvalho DP, Werneck de Castro JP (2013) Decreased serum T3 after an ex‑ ercise session is independent of glucocorticoid peak. Horm Metab Res 45: 893–899.
  • Okamoto M, Yamamura Y, Liu YF, Min‑Chul L, Matsui T, Shima T, Soya M, Takahashi K, Soya S, McEwen BS, Soya H (2015) Hormetic effects by exercise on hippocampal neurogenesis with glucocorticoid signaling. Brain Plast 1: 149–158.
  • Pilhatsch M, Marxen M, Winter C, Smolka MN, Bauer M (2011) Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques. Thyroid Res 4: S3.
  • Rivas  M, Naranjo JR (2007) Thyroid hormones, learning and memory. Genes Brain Behav 6: 40–44.
  • Roy G, Mugesh G (2006) Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase‑catalyzed oxidation and iodination reactions. Bioinorg Chem Appl 2006: 23214.
  • Roy RR, Zhong H, Hodgson JA, Grossman EJ, Edgerton VR (2003) Effect of altered thyroid state on the in situ mechanical properties of adult cat soleus. Cells Tissues Organs 173: 162–171.
  • Sala‑Roca J, Estebanez‑Perpina E, Balada F, Garau A, Martí‑Carbonell MA (2008) Effects of adult dysthyroidism on the morphology of hippocampal neurons. Behav Brain Res 188: 348–354.
  • Sandi C, Pinelo‑Nava MT (2007) Stress and memory: behavioral effects and neurobiological mechanisms. Neural Plast 2007: 78970.
  • Shafiee SM, Vafaei AA, Rashidy‑Pour A (2016) Effects of maternal hypothyroidism during pregnancy on learning, memory and hippocampal BDNF in rat pups: Beneficial effects of exercise. Neuroscience 329: 151–161.
  • Shen H, Tong L, Balazs R, Cotman CW (2001) Physical activity elicits sustained activation of the cyclic AMP response element‑binding protein and mitogen‑activated protein kinase in the rat hippocampus. Neuroscience 107: 219–229.
  • Shih PC, Yang YR, Wang RY (2013) Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PLoS One 8: e78163.
  • Shin MS, Ko IG, Kim SE, Kim BK, Kim TS, Lee SH, Hwang DS, Kim CJ, Park JK, Lim BV (2013) Treadmill exercise ameliorates symptoms of methimazole‑induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups. Int J Dev Neu‑ rosci 31: 214–223.
  • Smith ED, Prieto GA, Tong  L, Sears‑Kraxberger I, Rice JD, Steward O, Cotman CW (2014) Rapamycin and interleukin‑1β impair brain‑derived neurotrophic factor‑dependent neuron survival by modulating autophagy. J Biol Chem 289: 20615–20629.
  • Soya H, Nakamura T, Deocaris CC, Kimpara A, Iimura  M, Fujikawa T, Chang  H, McEwen BS, Nishijima T (2007) BDNF induction with mild exercise in the rat hippocampus. Biochem Biophys Res Commun 358: 961–967.
  • Stranahan AM, Lee K, Mattson MP (2008) Central mechanisms of HPA axis regulation by voluntary exercise. Neuromolecular Med 10: 118–127.
  • Tapia‑Rojas C, Aranguiz F, Varela‑Nallar L, Inestrosa NC (2016) Voluntary running attenuates memory loss, decreases neuropathological changes and induces neurogenesis in a mouse model of Alzheimer’s disease. Brain Pathol 26: 62–74.
  • Taurog A, Dorris ML (1989) A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinol‑ ogy 124: 3038–3042.
  • Torres‑Manzo AP, Franco‑Colín  M, Blas‑Valdivia  V, Pineda‑Reynoso  M, Cano‑Europa E (2018) Hypothyroidism causes endoplasmic reticulum stress in adult rat hippocampus: A mechanism associated with hippo‑ campal damage. Oxid Med Cell Longev 2018: 2089404.
  • Tozuka Y, Wada E, Wada K (2009) Diet‑induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J 23: 1920–1934.
  • Uda M, Ishido M, Kami K, Masuhara M (2006) Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult rat. Brain Res 1104: 64–72.
  • van Praag H, Kempermann G, Gage FH (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266–270.
  • Winocur G, Wojtowicz JM, Huang J, Tannock IF (2014) Physical exercise pre‑ vents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy‑treated rats. Psychopharmacology 231: 2311–2320.
  • Wrann CD, White JP, Salogiannnis J, Laznik‑Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM (2013) Exercise induces hippocampal BDNF through a PGC‑1α/FNDC5 pathway. Cell Metab 18: 649–659.
  • Yoshihara A, Luo Y, Ishido Y, Usukura K, Oda K, Sue  M, Kawashima A, Hiroi N, Suzuki K (2019) Inhibitory effects of methimazole and propylthiouracil on iodotyrosine deiodinase 1 in thyrocytes. Endocr J 66: 349–357.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-0f848ce0-be08-4f13-89c4-88c04ce24c8b
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.