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2009 | 59 | 2 |
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Shikimate pathway in yeast cels: enzymes, functioning, regulation - a review

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The shikimic acid pathway occurs in various groups of microorganisms, plants and parasites, while it does not occur in animal organisms. An interesting protein synthesized by the yeast is the product of ARO1 gene known as AROM protein. The occurrence of AROM protein in cells of the yeast is the most important difference as compared to the functioning of the shikimate pathway in other organisms. The shikimate pathway constitutes a good source for designing antimicrobial agents. The key industrial significance of shikimic acid pathway metabolites consists in shikimic acid application as a starter material for the synthesis of a neuraminidase inhibitor (GS4104) and agents used in the antitumor therapy. The knowledge on that pathway should be continuously extended in the aspect of potential acquisition of its metabolites.
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