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2011 | 71 | 1 |
Tytuł artykułu

"Neural” differentiation of bone marrow mesenchymal stem cells

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Therapeutic benefits of bone marrow MSCs use in the neurological disorders exist. Although, currently there is not a clear understanding of the detailed mechanisms by which MSCs mediate neural recovery. Early studies suggested that MSCs injected into the lateral ventricles of developing animals differentiated into neural cell types. However, latter data showed that appearance of GFAP positive MSCs derivatives was consequence of cells fusion. Moreover, older data suggesting transdifferentiation of mesenchymal stem cells into neural derivatives is poorly supported by the current data. Many of articles suggesting neural differentiation of bone marrow mesenchymal stem cells appeared as based on controversial, or even inconsistent data. Surprisingly, authors analyzing putative neural differentiation of bone marrow MSCc do not present corresponding results of neural differentiation of neural progenitors. Moreover, markers of neural differentiation can be misleading. To this end, neural differentiation of bone marrow mesenchymal stem cells should be considered as controversial.
Słowa kluczowe
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-
Rocznik
Tom
71
Numer
1
Opis fizyczny
p.169
Twórcy
autor
  • Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-0e91953b-ba48-48a1-b4a9-bb202a14b51d
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