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1988 | 39 | 4 |
Tytuł artykułu

Influence of chronic ethanol treatment and the abstinence period on the ethanol elimination by the isolated perfused rat liver

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Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Rajtar, G.: Influence of chronic ethanol treatment and the abstinence period, on the ethanol elimination by the .isolated perfused rat liver. Acta physiol, pol., 1988; 39 (4): 276-280. Rats received ethanol as their only (Irinking, fluid lor 4 weeks in a concentration ranging from 6-20%. After the ethanol-free intervals of 24, 48, 72, 96, 120 and 144 hours, the livers wereusolated and perfused with 100 ml of perfusion fluid with an addition of ethanol (0.2% f.c.) and the elimination of ethanol from the perfusate was studied. The livers of animals chronically exposed to ethanol showed significant diminution of ethanol elimination from perfusate after 72, 96 and 120 hours of withdrawal. After 144 hours the rate of the ethanol elimination returned to the control level.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
39
Numer
4
Opis fizyczny
p.276-280,fig.,ref.
Twórcy
autor
  • Department of Pharmacology, School of Medicine, Lublin, Poland
Bibliografia
  • 1. Halt, D. E. (1967) Effect of insulin on glucose metabolism by the perfused normal rat liver. Amer. J. Physiol. 213. 219.
  • 2. Iseri, O. A., Lieber, C. S., Gottlieb, L. S. (1966) The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Amer. J. Pathol. 48. 535-555.
  • 3. Keiding, S., Christensen, N. J., Damgaard, S. E., Dejgard, A., Iversen, H. L., Jacobsen, A., Johansen, S., Lundquist, F., Rubinstein, E., Winkler, K. (1933) Ethanol metabolism in heavy drinkers after massive and moderate alcohol intake. Bioch. Pharmacol. 32. 3097-3102.
  • 4. Korsten, M. A., Matsuzaki, S., Feinman, L., Lieber, C. S. (1975) High blood acetdldehyde levels after etlianol administration. Differences between alcoholic and non-alcoholic subjects. New Engl. J. Med. 292. 386-389.
  • 5. Lieber, C. S., De Carli, L. M. (1970) Hepatic microsomal ethanol oxidizing system. In vitro characteristics and adaptive properties in vivo. J. Biol. Chem. 245. 2505-2512.
  • 6. Matsuzaki, S., Gordon, E., Lieber, C. S. (1980) Increased alcohol dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes the effect of chronic ethanol feeding. J. Pharmacol. Exp. Ther. 217. 133-137.
  • 7. Pikikarainen, P., Lieber, C. S. (1980) Concentration dependency of ethanol elimination rates in baboons: Effect of chronic alcohol consumption, Alcoholism. Clin. Exp. Res. 4. 40-43.
  • 8. Rajtar, G. (1979) Influence of chlorpromazine, diazepam, imipramine and pyrazoleon ethanol-induced changes in activity of some enzymes in .isolated rat liver. Arch. Immunol. Ther. Exp. 27. 329-337.
  • 9. Salaspuro, M. P,, Shaw, S., Jayatilleke, E. (1981) Attenuation of ethanol-induced hepatic redox change after chronic alcohol consumption: Mechanism and metabolic consequences. Hepatology 1. 33-38.
  • 10. Shigeta, Y., Nomura, F., lida, S. (1984) Ethanol metabolism in vivo by the microsomal ethanol oxidazing system in deermice lacking alcohol dehydrogenase (ADH). Biochem. Pharmacol. 33. 807-814.
  • 11. Socaransky, S. M., Aragon, C. M. G., Amit, Z., Blander, A. (1984) Higher correlation of ethanol consumption with brain than liver aldehyde dehydrogenase in three strains of rats. Psychopharmacology 84. 250-253.
  • 12. Widmark, E. (1932) In die theoretischen Grundlagen und die practische Verwendbarkeit der gerichtlichen medizinischen Alkohoibestimmung, Berlin.
Typ dokumentu
Bibliografia
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