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2013 | 16 | 2 |

Tytuł artykułu

Imidazole-induced contractility of vascular smooth muscle cells in the presence of U-73122, ODQ, indomethacin and 7-nitroindazole

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to assess the impact of modulating factors on vascular smooth muscle cells reactivity. Vascular resistance was induced by the administration of increasing concentrations of imidazole. The experiments were performed on isolated and perfused tail artery of Wistar rats (weight 250 g – 350 g). Rats were been narcotized by urethane (intraperitoneal injection) at a dose of 120 mg/kg, stunned and then sacrificed by cervical dislocation. In the following investigation classical pharmacometric methods were used. Relationships between concentration-response curves (CRCs) for imidazole observed in the presence of ODQ [(1H-(1,2,4)oxadiazolo-[4,3-a]quinoxalin-1-one)], 7-nitroindazole and indomethacin were analyzed. Imidazole-induced contractility of vascular smooth muscle cells was independent from alpha-adrenergic receptors and PLC activity. Reactivity of VSMCsinduced by imidazole, was significantly changed in the presence of ODQ and 7-nitroindazole.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

16

Numer

2

Opis fizyczny

p.293-297,fig.,ref.

Twórcy

autor
  • Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland
autor
  • Department of Pediatrics, Hematology and Oncology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland
  • Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland
autor
autor
  • Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland
  • Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland
autor
  • Department of Natural Sciences, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland
autor
  • Department of Natural Sciences, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland
autor
  • Department of Human Anatomy, Medical University in Bialystok, A. Mickiewicza 2A, 15-230 Białystok, Poland
  • Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Polan
autor
  • Department of Physical Education, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland

Bibliografia

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  • Callado LF, Martin-Gomez Jl, Ruiz J, Garibi JM, Meana JJ (2004) Imidazoline I₂ receptor density increases with the malignancy of human gliomas. J Neurol Neurosurg Psychiatry 75: 785-787.
  • Chen MJ, Zhu HE, Piletz JF (2003) Intracellular effect of imidazoline receptor on α2A-noradrenergic receptor. Ann N Y AcadSci 1009: 427-438.
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  • El-Ayoubi R., Menaouar A, Gutkowska J, Mukaddam-Daher S (2004) Imidazoline receptors but not α2-adrenoreptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J Pharmacol Exp Ther 310: 446-451
  • El-Mas MM, Omar AG, Helmy MM, Mohy El-Din MM (2009) Interruption of central neuronal pathway of imidazoline I₁ receptor mediates the hypertensive effect of cyclosporine in rats. Brain Res 1248: 96-106.
  • Garcia-Sevilla JA, Escribá PV, Guimón J (1999) Imidazoline receptors and human brain disorders. Ann N Y Acad Sci 881: 392-409.
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  • Grześk G, Kozinski M, Navarese EP, Krzyzanowski M, Grześk E, Kubica A, Siller-Matula JM, Castriota F, Kubica J (2012) Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: a placebo- controlled study in rats. Thromb Res 130: 65-69.
  • Grześk G, Szadujkis-Szadurski L (2001) Pharmacometric analysis of alpha₁-adrenoceptor function in rat tail artery pretreated with lipopolysaccharides. Pol J Pharmacol 53: 605-613.
  • Grześk G, Wiciński M, Malinowski B, Grześk E, Manysiak S, Odrowąż-Sypniewska G, Darvish N, Bierwagen M (2012) Calcium blockers inhibit cyclosporine A-induced hyper-reactivity of vascular smooth muscle cells. Mol Med Rep 5: 1469-1474.
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  • Munroe PB, Caulfield MJ (2000) Genetics of hypertension. Curr Opin Genet Dev 10: 325-329.
  • Narahashi T (2000) Neuroreceptors and ion channels as the basis for drug action: past, present and future. J Pharmacol Exp Ther 294: 1-26.
  • Nielsen SF, Nielsen EO, Olsen GM, Liljefors T, Peters D (2000) Novel potent ligands for the central nicotinic acetylocholine receptor: synthesis, receptor binding, and 3D-QSAR analysis. J Med Chem 43: 2217-2226.
  • Nikolic K, Filipic S, Agbaba D (2009) QSAR study of selective I₁-imidazoline receptor ligands. SAR QSAR Environ Res 20: 133-144.
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Bibliografia

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