Imidazole-induced contractility of vascular smooth muscle cells in the presence of U-73122, ODQ, indomethacin and 7-nitroindazole

• Autorzy: Wicinski M. , Grzesk G. , Malinowski B. , Grzesk E. , Sinjab A. T. , Krzyzanowski M. , Michalska A. , Bylina D. , Dzieciol J. , Szadujkis-Szadurska K. , Czeczuk A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to assess the impact of modulating factors on vascular smooth muscle cells reactivity. Vascular resistance was induced by the administration of increasing concentrations of imidazole. The experiments were performed on isolated and perfused tail artery of Wistar rats (weight 250 g – 350 g). Rats were been narcotized by urethane (intraperitoneal injection) at a dose of 120 mg/kg, stunned and then sacrificed by cervical dislocation. In the following investigation classical pharmacometric methods were used. Relationships between concentration-response curves (CRCs) for imidazole observed in the presence of ODQ [(1H-(1,2,4)oxadiazolo-[4,3-a]quinoxalin-1-one)], 7-nitroindazole and indomethacin were analyzed. Imidazole-induced contractility of vascular smooth muscle cells was independent from alpha-adrenergic receptors and PLC activity. Reactivity of VSMCsinduced by imidazole, was significantly changed in the presence of ODQ and 7-nitroindazole.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 2
• Opis fizyczny: p.293-297,fig.,ref.

Twórcy

autor

Wicinski M.

• Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland

autor

Grzesk G.

• Department of Pediatrics, Hematology and Oncology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland

autor

Malinowski B.

• Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland

autor

Grzesk E.

autor

Sinjab A. T.

• Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland

autor

Krzyzanowski M.

• Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Poland

autor

Michalska A.

• Department of Natural Sciences, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland

autor

Bylina D.

• Department of Natural Sciences, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland

autor

Dzieciol J.

• Department of Human Anatomy, Medical University in Bialystok, A. Mickiewicza 2A, 15-230 Białystok, Poland

autor

Szadujkis-Szadurska K.

• Department of Pharmacology and Therapeutics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, M. Curie 9, 85-090 Bydgoszcz, Polan

autor

Czeczuk A.

• Department of Physical Education, Faculty of Physical Education and Sport, in Biala Podlaska, Akademicka 2, 21-500 Biała Podlaska, Poland

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