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2014 | 17 | 2 |
Tytuł artykułu

The effect of beta-hydroxy-beta-methylbutyrate (HMB) on selected parameters of humoral immunity in calves

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The objective of this study was to evaluate the effect of HMB on selected parameters of the humoral immunity in calves. The experiment was performed on 14 calves aged 30 ± 2 days, divided into two equal groups of control (group K) and experimental (group H) animals. The feed administered to the experimental calves was supplemented with HMB at 40 mg/kg BW, whereas the control calves were administered standard farm-made feed without supplementation. Blood was sampled from the jugular vein immediately before the experiment (day 0) and on experimental days 15, 30 and 60 to determine the following immunological parameters: total protein levels, gammaglobulin levels, lysozyme activity and ceruloplasmin activity. An analysis of the results obtained revealed a significant increase (p < 0.05; p < 0.01; p < 0.001 respectively) in gammaglobulin levels and lysozyme activity throughout the entire experimental period, an increase (p < 0.05; p < 0.01 respectively) in ceruloplasmin activity on experimental days 15 and 30, but no changes in serum total protein levels of calves administered HMB as compared to those found in the control group.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
17
Numer
2
Opis fizyczny
p.357-359,ref.
Twórcy
autor
  • Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland
  • Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland
  • Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland
autor
  • Department of Cattle Breeding and Milk Quality Evaluation, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn, Poland
  • Department of Cattle Breeding and Milk Quality Evaluation, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn, Poland
Bibliografia
  • Gatnau R, Zimmerman DR, Nissen SL, Wannemuehler M, Ewan RC (1995) Effect of excess dietary leucine and leucine catabolites on growth and immune response in weanling pigs. J Anim Sci 73: 159-165.
  • Krakowski L, Krzyzanowski J, Wrona Z, Kostro K, Siwicki AK (2002) The influence of nonspecific immunostimulation of pregnant sows on the immunological value of colostrum. Vet Immunol Immunopathol 87: 89-95.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193: 265-275.
  • Ostaszewski P, Siwicki AK, Skrzek Z, Balasinska B, Fuller JC Jr, Nissen S (1998) β-hydroxy-β-methylbutyrate (HMB) fed in the water enhances immune response in young broilers. Poultry Sci 77 (Suppl 1): 26
  • Parry RM Jr, Chandan RC, Shahani RM (1965) A rapid and sensitive assay of muramidase. Proc Soc Exp Biol Med 119: 384-386.
  • Peterson AL, Qureshi MA, Ferket PR, Fuller JC Jr (1999) In vitro exposure with beta-hydroxy-beta-methylbutyrate enhances chicken macrophage growth and function. Vet Immunol Immunopathol 67: 67-78.
  • Puchajda-Skowrońska H, Siwicki AK, Wójcik R, Pudyszak K (2006) Effects of 3-hydroxy-3-methylbutyrate (HMB) on selected performance indices and non-specific defense mechanisms in geese. Med Weter 62: 89-92.
  • Siwicki AK, Anderson DP (1993) Immunostimulation in fish: measuring the effects of stimulants by serological and immunological methods. US Fish Wildlife Service, IFI, Olsztyn 1: 17.
  • Siwicki AK, Studnicka M (1986) Ceruloplasmin activity in carp (Cyprinus carpio). Bamidgeh 38: 126-129.
  • Siwicki AK, Zakęś Z, Fuller JC Jr, Nissen S, Kazuń K, Głąbski E (2006) The influence of β-hydroxy-β-methylbutyrate (HMB) on cell-mediated immunity in tench Tinca tinca (L.): in vitro and in vivo. Aquac Int 14: 153-161.
  • Talleyrand V, Dorn A, Frank D, Roth J, Nissen S (1994) Effect of feeding β-hydroxy-β-methylbutyrate on immune function in stressed calves. FASEB J 8: A951.
  • Van Koevering MT, Nissen S (1992) Oxidation of leucine and α-ketoisocaproate to β-hydroxy-β-methylbutyrate in vivo. Am J Physiol 262: E27-E31.
  • Vukovich MD, Slater G, Macchi MB, Turner MJ, Fallon K, Boston T, Rathmacher J (2001) Beta-hydroxy-beta- -methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. J Nutr Biochem 12: 631-639.
  • Wójcik R, Małaczewska J, Siwicki AK, Miciński J, Zwierzchowski G (2013) The effect of β-hydroxy-β-methylbutyrate (HMB) on the proliferative response of blood lymphocytes and the phagocytic activity of blood monocytes and granulocytes in calves. Pol J Vet Sci 16: 567-569.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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