Mismatch between transcriptomic and histopathologic picture of canine lymphomas

• Autorzy: Ostrzeszewicz M. , Maciejewski H. , Sapierzynski R. , Micun J. , Majewska A. , Lechowski R. , Motyl T. , Jank M.
• Języki publikacji: EN

Abstrakty

EN

Lymphoma is one of the most common malignant tumours occurring in dogs. Since there is a constant need for new, more comprehensive laboratory diagnostic tools which permit the precise determination of many tumour-related factors we decided to verify whether the use of microarray analysis could be helpful in classifying lymphomas. The study was performed on samples collected from 7 dogs in which multicentric lymphoma was recognized. Among this group we were able to identify one sub-cluster of transcriptionally similar tumours, which completely differed in terms of the histopathological examination. Among them there were one diffuse large B cell lymphoma, one diffuse macronucleolated medium-sized cell lymphoma and one pleomorphic mixed small and large T-cell lymphoma. The lymphomas belonging to the sub-cluster differed from other analysed tumours in the expression of more than 100 genes of which only 18 were described earlier in regard to lymphomas.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2012
• Tom: 15
• Numer: 4
• Opis fizyczny: p.781-790,fig.,ref.

Twórcy

autor

Ostrzeszewicz M.

• Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warsaw, Poland

autor

Maciejewski H.

• Institute of Computer Engineering, Control and Robotics (I-6), Wroclaw University of Technology, Wroclaw, Poland

autor

Sapierzynski R.

• Institute of Computer Engineering, Control and Robotics (I-6), Wroclaw University of Technology, Wroclaw, Poland

autor

Micun J.

• Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warsaw, Poland

autor

Majewska A.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland

autor

Lechowski R.

• Department of Small Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warsaw, Poland

autor

Motyl T.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland

autor

Jank M.

• Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland

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