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2013 | 20 | 1 |
Tytuł artykułu

Effect of menopausal hormone therapy on the levels of magnesium, zinc, lead and cadmium in post-menopausal women

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EN
Abstrakty
EN
Introduction and objective: The level of trace elements is extremely important for the maintenance of normal functioning of the human body. The risk of disturbance of their balance increases especially dynamically during the period of menopause. The objective of the study was the effect of MHT on the levels of bioelements (Mg and Zn) in blood plasma, and toxic metals (Pb and Cd) in the whole blood in postmenopausal women. Materials and methods: The study covered 323 women at postmenopausal age from the population of the West Pomeranian Region, in whom the levels of Mg, Zn, Pb and Cd were determined. The women were divided into two groups: study and control. The study group were 152 women who used menopausal hormone therapy (MHT). The control group were 171 women who did not use MHT, and had had their final menstrual period at least one year prior to inclusion in the study. The mean age of the women examined was 56±5. Results: Significantly higher levels of the bioelements Mg, Zn were observed in women who used MHT, compared to the control group (p<0.05). The concentration of Pb in whole blood was significantly lower in the study than the control group: 16.09±7.33 μg/l and 20.18±9.01 μg/l, respectively. An elevated level of Cd in whole blood was found in both groups of women: 0.9±1.03 μg/l and 0.8±1.1 μg/l, respectively. It was noted that women who used MHT more frequently declared the presence of climacteric symptoms (p<0.05). Conclusions: 1) Higher levels of Mg and Zn were found in blood plasma of women who used MHT. 2) The mean concentration of Cd in the blood of women in both groups was similar. 3) In women who use MHT the level of Pb in whole blood was lower, compared to the rest of the women.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
20
Numer
1
Opis fizyczny
p.147-151,fig.,ref.
Twórcy
autor
  • Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland
autor
  • Laboratory of Primary Health Care, Pomeranian Medical University, Szczecin, Poland
autor
  • Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland
  • Public Health Department, Pomeranian Medical University, Szczecin, Poland
  • Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland
  • Laboratory of Propaedeutics in Nursing, Pomeranian Medical University, Szczecin, Poland
autor
  • Public Health Department, Pomeranian Medical University, Szczecin, Poland
  • Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland; Faculty of Pedagogy and Psychology, University of Economics and Innovation, Lublin, Poland
autor
  • Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
Bibliografia
  • 1. Taylor HS, Manson JE. Update in Hormone Therapy Use in Menopause. J Clin Endocrinol Metab. 2011; 96(2): 255-264.
  • 2. Marara-Studziańska M, Wdowiak A, Bakalczuk G, Bakalczuk S. Wpływ terapii hormonalnej na poziom depresji i jakość życia kobiet w wiekuokoło menopauzalnym, zamieszkujących tereny wiejskie. PrzeglMenopauz. 2009; 5: 284-289.
  • 3. Heiss G, Wallace R, Anderson GL, Aragaki A, Beresford SA, Brzyski R, et al. WHI Investigators. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA2008; 299: 1036–1045.
  • 4. Song CH, Barrett-Connor E, Chung JH, Kim SH, Kim KS. Associations of calcium and magnesium in serum and hair with bone mineral densityin premenopausal women. Biol Trace Elem Res. 2007; 118(1): 1-9.
  • 5. Hasik J, Hryniewiecki L, Grzymisławski M. Dietetyka. Wydawnictwo Lekarskie PZWL, Warszawa 1999: 48-50.
  • 6. Davis SR. Menopause: New therapies. MJA 2003; 178: 634-637.
  • 7. Fitzpatrick LA, Santen RJ. Editorial: Hot Flashes: The Old and the New, What Is Really true? Mayo Clin Proc. 2002; 77: 1155-1158.
  • 8. Baber R. Phytoestrogens and post reproductive health. Maturitas. 2010; 66: 344-9.
  • 9. Toxicological profile for lead. U.S. Department of Health and Human Services. Public Health Service. Agency for Toxic Substances and Disease Registry, 2007.
  • 10. Szkup-Jabłońska M, Karakiewicz B, Grochans E, Jurczak A, Nowak- Starz G, Rotter I, Prokopowicz A. Effects of blood lead and cadmium levels on the functioning of children with behaviour disorders in the family environment. Ann Agric Environ Med. 2012; 19(2): 241-246.
  • 11. Borja-Aburto VH, Hertz-Picciotto I, Lopez MR, et al. Blood lead levels measured prospectively and risk of spontaneous abortion. Am JEpidemiol. 1999; 150: 590-597.
  • 12. Sallmén M, Lindbohm ML, Anttila A, et al. Time to pregnancy among the wives of men occupationally exposed to lead. Epidemiology 2000;11: 141-147.
  • 13. Chan OY, Poh SC, Lee HS, et al. Respiratory function in cadmium battery workers: A followup study. Ann Acad Med Singapore. 1988;17: 283-287.
  • 14. Olewińska E, Kasperczyk A, Kapka L, Kozłowska A, Pawlas N, Dobrakowski M, Birkner E, Kasperczyk S. Level of DNA damage in lead-exposed workers. Ann Agric Environ Med. 2010; 17(2): 231-6.
  • 15. Draft Toxicological profile for cadmium. U.S. Department of Health and Human Services. Public Health Service. Agency for Toxic Substances and Disease Registry, 2008.
  • 16. Sałacka A, Kozielec T, Karakiewicz B. Zawartość kadmu i cynku we włosach u ludzi dorosłych po doustnej suplementacji magnezu. MedŚrodowiskowa 2010; 13(1): 60-64.
  • 17. Cyril Long. Biochemists handbook. D.Van Nostrand Company. Princeton, New Jersey 1964.
  • 18. Meram I, Balat O, Tamer L, Ugur MG. Trace elements and vitamin levels in menopausal women receiving hormone replacement therapy.Clin Exp Obstet Gynecol. 2003; 30(1): 32-4.
  • 19. Bureau I, Anderson RA, Arnaud J, Raysiguier Y, Favier AE, Roussel AM. Trace mineral status in post menopausal women: impact of hormonalreplacement therapy. J Trace Elem Med Biol. 2002; 16(1):9-13.
  • 20. Seelig MS, Altura BM, Altura BT. Benefits and Risks of Sex Hormone Replacement in Postmenopausal Women. J Am Coll Nutr. 2004; 23(5):482S-496S.
  • 21. Welton AJ, Vickers MR, Kim J, Ford D, Lawton BA, MacLennan AH, Meredith SK, Martin J, Meade TW. WISDOM team. Health related quality of life after combined hormone replacement therapy:randomised controlled trial. BMJ 2008; 337: a1190.
  • 22. Sunar F, Gormus ZI, Baltaci AK, Mogulkoc R. The effect of low dose zinc supplementation to serum estrogen and progesterone levels inpost-menopausal women. Biol Trace Elem Res. 2008; 126(1): S11-4.
  • 23. Sunar F, Baltaci AK, Ergene N, Mogulkoc R. Zinc deficiency and supplementation in ovariectomized rats: their effect on serum estrogenand progesterone levels and their relation to calcium and phosphorus.Pak J Pharm Sci. 2009; 22(2): 150-4.
  • 24. Nilsson U, Atewell R, Christoffersson JO, et al. Kinetics of lead in bone after end of occupational exposure. Pharmacol Toxicol. 1991;69: 477–484.
  • 25. Potula V, Kaye W. The impact of menopause and lifestyle factors on blood and bone lead levels among female former smelter workers: TheBunker Hill Study. Am J Ind Med. 2006; 49: 143–152.
  • 26. Webber CE, Chettle DR, Bowins RJ, et al. Hormone replacement therapy may reduce the return of endogenous lead from bone to the circulation. Environ Health Perspect. 1995; 103: 1150–1153.
  • 27. Hu FB, Grodstein F. Postmenopausal hormone therapy and the risk of cardiovascular disease: The epidemiologic evidence. Am J Cardiol.2002; 90: 26F–29F.
  • 28. Symanski E, Hertz PI. Blood lead levels in relation to menopause, smoking, and pregnancy history. Am J Epidemiol. 1995; 141: 1047-1058.
  • 29. Genant HK, Cann CE, Ettinger B, Gordan GS. Quantitative computed tomography of vertebral spongiosa: A sensitive method for detectingearly bone loss after oophorectomy. Clin Orthop. 2002; 372: 3–8.
  • 30. Nash D, Magder L, Lustberg M, Sherwin RW, Rubin RJ, Kaufmann RB, Silbergeld EK. Blood lead, blood pressure, and hypertension inperimenopausal and postmenopausal women. JAMA. 2003; 289(12):1523–1532.
  • 31. Muldoon SB, Cauley JA, Kuller LH, et al. Lifestyle and sociodemographic factors as determinants of blood lead levels in elderly women. Am JEpidemiol. 1994; 139: 599-608.
  • 32. Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S, Vahter M. Cadmium-induced effects on bone in apopulation-based study of women. Environ Health Perspect. 2006;114(6): 830-4.
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Bibliografia
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