Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease

• Autorzy: Kwiatek-Majkusiak J. , Dickson D.W. , Tacik P. , Aoki N. , Tomasiuk R. , Koziorowski D. , Friedman A.
• Języki publikacji: EN

Abstrakty

EN

Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p<0.001, p=0.025, p=0.029). A significant correlation was also found between the concentration of L-ferritin and neuronal loss (p=0.0026). These findings indicate an important role of ferritin light chains in neurodegeneration, that is linked to chronic inflammation processes and the associated activation of the microglia rich of L chains.

Słowa kluczowe

EN

relationship; histopathological hallmark; ferritin; hippocampus; human disease; patient; Alzheimer's disease; neuronal loss; neurodegenerative disease

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: 4
• Opis fizyczny: p.391-398,fig.,ref.

Twórcy

autor

Kwiatek-Majkusiak J.

• Department of Neurology, Medical University of Warsaw, Warsaw, Poland

autor

Dickson D.W.

• Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA

autor

Tacik P.

• Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA

autor

Aoki N.

• Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA

autor

Tomasiuk R.

• Biochemistry Laboratory, Brodno Voivodship Hospital, Warsaw, Poland

autor

Koziorowski D.

• Department of Neurology, Medical University of Warsaw, Warsaw, Poland

autor

Friedman A.

• Department of Neurology, Medical University of Warsaw, Warsaw, Poland

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