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2011 | 71 | 4 |
Tytuł artykułu

Structural neuroplasticity induced by melatonin in entorhinal neurons of rats exposed to toluene inhalation

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Several clinical studies have shown that abusing volatile solvents, mainly toluene, produces neurological, neuropathological and neuropsychiatry disorders. Symptoms of these disorders include loss in impulse control, distractibility and memory deficits, which are associated with mild brain atrophy. The entorhinal cortex is critically involved in mnemonic processes, and memory disorders are the major symptom detected in chronic solvent abusers. Therefore, in the present study, we evaluated (1) whether the entorhinal neuronal morphology was impaired by subchronic toluene exposure and (2) if melatonin protected the neuronal cytoarchitecture, as has been demonstrated in neocortical neurons. Consistent with our previous findings, the present study indicates that the entorhinal cell dendritic arborization was significantly reduced in toluene- exposed animals, and melatonin administration significantly rescued the reduced dendritic branching induced by toluene neurotoxicity.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
71
Numer
4
Opis fizyczny
p.541-547,fig.,ref.
Twórcy
autor
  • Laboratorio de Neurociencias, Escuela de Kinesiologia, Facultad de Ciencias, Pontificia Univesidad Catolica de Valparaiso, Avenida Brasil 2950, Valparaiso, Chile
  • Laboratorio de Neurociencias, Escuela de Kinesiologia, Facultad de Ciencias, Pontificia Univesidad Catolica de Valparaiso, Avenida Brasil 2950, Valparaiso, Chile
Bibliografia
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  • Bowen SE, McDonald P (2009) Abuse pattern of toluene exposure alters mouse behavior in a waiting-for-reward operant task. Neurotoxicol Teratol 31: 18-25.
  • Carloni S, Perrone S, Buonocore G, Longini L, Proietti F, Balduini W (2008) Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J Pineal Res 44: 157-164.
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