Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 60 | 1 |
Tytuł artykułu

Evaluation of potential health benefits of two novel special foods in liver cirrhotic patients

Treść / Zawartość
Warianty tytułu
Języki publikacji
Two therapeutic diets have been formulated (A & B) and prepared in bakery form for patients with liver cirrhosis. The formulation was based on the presence of protein of high Fisher ratio and fat rich in medium chain triglycerides. Both formulas contained edible sources of antioxidants. Honey was added as a sweetener. Proximate analysis of Formula B and its contents of amino acids and fatty acids were carried out. Formula A was analysed in previous research for the same above mentioned composition. The two formulas were sensory evaluated by liver cirrhotic patients. Potential benefits of both formulas in addition of nutritional advice were evaluated in liver cirrhotic patients. Biochemical parameters reflecting liver function (plasma AST, ALT, ALP, total bilirubin, direct bilirubin and ammonia), oxidative stress (plasma NO and MDA) and nutritional status (plasma total protein, albumin, globulin and A/G ratio) were studied before and after two months of dietary intervention. The nutritional status of patients was evaluated through anthropometric measurements, food intake and selected biochemical parameters. Proximate analysis results showed that formula B contain 17.6% protein and 7.5% fat. Amino acids analysis of the same formula showed that its Fisher ratio was 2.49. GC analysis of fatty acids revealed that medium chain fatty acids constitute 38.6% of total fatty acids. The results of sensory evaluation showed that overall score of formula A was significantly higher than that of formula B. Nutritional status determined through triceps skin fold at the start of the clinical study showed 38% of cases were normal, 8% were severely malnourished and 54% over normal. Analysis of mean dietary intake of patients in the beginning of the study revealed that all liver cirrhotic patients were hypo-caloric. All estimated nutrients were lower than RDA except for protein. Mean dietary intake of patient after two months of the study revealed that all patients increased their caloric intake however they were still hypo-caloric. Comparing biochemical parameters of patients before and after dietary intervention of either formulas and nutritional advice revealed that all parameters reflecting liver dysfunction were non significantly improved. However AST activity significantly decreased on supplementation of diet A. A significant increase in plasma albumin and total protein was noticed in patients after both dietary interventions which may reflect some improvements in liver synthetic function and nutritional status. Ammonia was only significantly decreased in patients given formula A. Nitric oxide and MDA were significantly reduced in both dietary interventions with different degrees. In conclusion, both dietary interventions in addition of dietary advice in the present study have beneficial effects towards liver cirrhotic patients concerning reduction of oxidative stress and inflammation. Formula A was superior in reducing plasma AST activity and ammonia level.
Słowa kluczowe
Opis fizyczny
  • Food Sciences and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt
  • 1. Abdel Fatah M.M., Al-Okbi S.Y., Ramadan K.S., Mohamed D.A., Mohammed S.E., Potential beneficial effect of functional food components in Alzheimer’ disease. Academia Arena, 2009, 1, 2, 55–68.
  • 2. Al-Ghamdi M.S., Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage. Am. J. Chin. Med., 2003, 31, 721–728.
  • 3. Antonio J.E., Lars Ove D., Bahram D., Raquel P., Fulgencio S., In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. J. Agric. Food, 2003, 51, 5540–5545.
  • 4. AOAC, Official Methods of Analysis of the Association of Official Analytical Chemists, 1995, 12th ed. Washington DC.
  • 5. Britton R.S., Bacon B.R., Role of free radicals in liver diseases and hepatic fibrosis. Hepatogastroenterology, 1994, 41, 343–348.
  • 6. Cabre G.E., Gassull D.M.A., Nutrition and chronic liver disease. Nutr. Hosp., 1999, Suppl, 2, 62S-70S.
  • 7. Chen L., Mehta A., Berenbaum M., Zangerl A.R., Engeseth N.J., Honeys from different floral sources as inhibitors of enzymatic browning in fruit and vegetable homogenates. J. Agric. Food Chem., 2000, 48, 4997–5000.
  • 8. Cottrell R.C., Nutritional aspects of palm oil. Am. J. Clin. Nutr., 1991, 53, 989S-1009S.
  • 9. Doumas B.T., Watson W.A., Biggs H.G., Albumin standards and the measurement of serum albumin with bromocresol green. Clin. Chem. Acta., 1972, 31, 87–96.
  • 10. FAO/WHO., Food and Nutrition board, National Research Council, Nutritional Academy of Science, 1989.
  • 11. Figueredo F.A., De Mello Perez R., Kondo M., Effect of liver cirrhosis on body composition: evidence of significant depletion even in mild disease. J. Gasroenterol. Hepatol., 2005, 20, 209–216.
  • 12. Frisancho A.R., Triceps skin fold and upper arm muscle size norms for assessment of nutritional status. Am. J. Clin. Nutr., 1974, 27, 1052–1058.
  • 13. Food Composition Tables for the Near East. FAO of the United Nation, Rome, 1982.
  • 14. Gambino S.R., in: Standard Methods of Clinical Chemistry, 1965, vol. 5, (ed. S. Meites). Academic Press, New York, p. 55–– 64.
  • 15. George A.B., What is the ideal body weight? J. Nutr. Biochem., 1998, 9, 489–492.
  • 16. Gips G.H., Wibbens-Alberts M., Ammonia determination in blood using the TCA direct method. Clin. Chim. Acta., 1968, 22, 183–186.
  • 17. Haussinger D., Nitrogen metabolism in liver: Structural and functional organization and physiological relevance. Biochem. J., 1990, 267, 281.
  • 18. Gundling F., Schepp W., Nutrition in liver cirrhosis: Diagnostic aspects and treatment. Dtsch. Med. Wochenschr., 2008, 133, 846–51.
  • 19. Kalra J., Mantha S.V., Prasad K., Oxygen free radicals: Key factors in clinical disease. Lab. Med. Int.., 1994, 11, 16–20.
  • 20. Kaufman S.S., Murray N.D, Wood R.P., Shaw B.W., Vanderhoof J.A., Nutritional support for the infant with extrahepatic biliary atresia. J. Pediatrics, 1987, 110, 679–686.
  • 21. Kochmar J.F., Moss D.W., Fundamentals of Clinical Chemistry. 1976 (ed. N.W. Tietz). W. B. Saunders and Company, Philadephia, PA, p. 604.
  • 22. Laviano A., Muscaritoli M., Cascino A., Preziosa I., Inui A., Mantovani G., Rossi-Fanelli F., Branched-chain amino acids: The best compromise to achieve anabolism. Curr. Opin. Clin. Nutr. Metab. Care, 2005, 8, 408–414.
  • 23. Lee K.G., Mitchell A., Shibamoto T., Antioxidative activities of aroma extracts isolated from natural plants. Biofactors, 2000, 13, 173–178.
  • 24. Lieber C.S., Nutrition in liver disorders. 1999, in: Modern Nutrition in Health and Disease, Baltimore, MD: Williams, Wilkins, pp. 1179–1180.
  • 25. Mackle T.R., Dwyer D.A., Bauman D.E., Effect of branchedchain amino acids and sodium caseinate on milk protein concentration and yield from dairy cows. J. Dairy Sci., 1999, 82, 161–171.
  • 26. Maio R., Dichi J.B., Burini R.C., Sensibility of anthropometriclaboratory markers of protein-energy malnutrition in cirrhotic patients. Arq. Gastroenterol., 2004, 41, 93–99.
  • 27. Marchesini G., Bianchi G., Zoli M., Plasma amino acid response to protein ingestion in patients with liver cirrhosis. Gastroenterology, 1983, 85, 283–290.
  • 28. Marchesini G., Bianchi G., Rossi B., Brizi M., Mechinda N.J., Nutritional treatment with branched chain amino acids in ad vanced liver cirrhosis. J. Gastroenterol., 2000, 35, Suppl. 12, 7–13.
  • 29. McCullough A.J., Tavill A.S., Disordered energy and protein metabolism in liver disease. Semin Liver Dis., 1991, 11, 265–277.
  • 30. Meiselman H.L., Scales for measuring food preferences. 1978, in: Encyclopedia of Food Sciences (eds. M.S. Petersen, A.H. Johnson). AVI, Westport, CT, pp. 675–688.
  • 31. Mobarhan S., Nutrition support for individuals with liver failure. Nutr. Rev., 2000, 58, 2, 42–47.
  • 32. Mohamed D.A., Al-Okbi S.Y., In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Pol. J. Food Nutr. Sci., 2004, 13/54, 397–402.
  • 33. Mohamed D.A., Al-Okbi S.Y., Preparation and evaluation of two special foods in rats with liver cirrhosis. Medical Journal of Islamic World Academy of Sciences, 2009, 17, 1, 45–52.
  • 34. Molleston JP., Acute and chronic liver disease. 1996, in: Nutrition in Paediatric, Basic Sciences and Clinical Application (eds. Walker W.A., Watkins JB.). B.C. Decker Inc. Publisher, Hamilton, London, p. 565.
  • 35. Monsen E., Metabolic effects of liver cirrhosis and nutritional intake. J. Am. Diet. Assoc., 1999, 99, 872.
  • 36. Monttgomery H.A.C., Dymock J.F., The determination of nitrite in water. Analyst, 1961, 86, 414–416.
  • 37. Mõrk H., Basics of nutrition in cirrhosis of the liver. MMW Fortschr Med., 2007, 149, 33–34.
  • 38. Novy M.A., Schwarz K.B., Nutritional consideration and management of the child with liver disease. Nutrition, 1997, 13, 177–184.
  • 39. Oomah B.D., Flaxseed as a functional food source. J. Sci. Food Agric., 2001, 81, 889–894.
  • 40. Paiva S.A., Russell R.M., Beta-carotenoids as antioxidants. J. Am. Coll. Nutr., 1999, 18, 424–433.
  • 41. Reitman S., Frankel S., Colorimetric methods for aspartate and alanine aminotransferase. Am. J. Clin. Path., 1957, 28, 56–63.
  • 42. Rheinhold J.G., Total protein, albumin and globulin. 1953, in: Standard methods of Clinical Chemistry, vol. 1 (ed. D. Seligron). Academic Press Inc., New York, p. 88.
  • 43. Satoh K., Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin. Chim. Acta, 1978, 90, 37–43.
  • 44. Schnuwisss B., Pammer J., Ratheiser K., Energy metabolism in acute hepatic failure. Gastroenterology, 1993, 105, 1515–1520.
  • 45. Spackman D.H., Stein W.H., Moore S., Automatic recording apparatus for use in the chromatography of amino acids. Anal Chem., 1958, 30, 1190–1206.
  • 46. Speroni E., Cevellati R., Govoni P., Guzzardi S., Renzulli C., Guerra M.C., Efficacy of different Cynara scolymus preparations on liver complains. J. Ethnopharmacol., 2003, 86, 203–211.
  • 47. Sumida Y., Nakashima T., Yoh T., Furutant M., Hirohoma A., Serum thioredoxin levels as a predictor of steatohepatitis in patients with non alcoholic fatty liver disease. J. Hepatol., 2003, 38, 32.
  • 48. Trinder P., Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem., 1969, 6, 24–25.
  • 49. Vogel A.I., Practical Organic Chemistry, 1961, 3rd ed.; Longmans Private LTD, Calcutta, Bombay, Madras.
  • 50. Watanabe A., Okada K., Shimizu Y., Wakabayashi H., Higuchi K., Niiya K., Kuwabara Y., Yasuyama T., Ito H., Tsukishiro T., Kondoh Y., Emi N., Kohri H., Nutritional therapy of chronic hepatities by whey protein (non-Heated). J Med., 2000, 31, 283–302.
  • 51. Wong C.W., Regester G.O., Francis G.L., Watson D.L., Immunomodulatory activities of whey fractions in efferent prefemoral lymph of sheep. J. Dairy Res., 1996, 63, 257–267.
  • 52. Yu L., Haley S., Perret J., Harris H., Wilson J., Qian M., Free radical scavenging properties of wheat extracts. J. Agric. Food Chem., 2002, 50, 1619–1624.
  • 53. Zamora R., Alaiz M., Hidalgo F.J., Determination of N-pyrrolylnorleucine in fresh food products J. Agric. Food Chem. 1999, 47, 1942–1947.
Rekord w opracowaniu
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.