Glutamatergically-induced theta oscillations recorded in both in vitro and in vivo maintained posterior hypothalamic preparations

• Autorzy: Kowalczyk T. , Bocian R. , Caban B. , Golebiewski H. , Kazmierska P. , Konopacki J.
• Języki publikacji: EN

Abstrakty

EN

Theta rhythm is the best synchronized EEG activity recorded from the mammalian brain. In rodents this EEG pattern consists of high-voltage, almost sinusoidal oscillations in the range of 3–12 Hz. Hippocampal formation (HPC) is considered to be the main structure involved in the generation of this activity. Anatomical and electrophysiological studies have revealed that the ascending brainstem hippocampal synchronizing pathway, which originates in pontine region, constitutes a major source of extensive inputs to the HPC. Fibres from pontine nuclei ascend to the posterior hypothalamic (PH) area and then PH neurons projects to medial septal area. There are evidences from physiological and pharmacological studies supporting the view that the PH region forms a critical part of the ascending synchronizing pathway linking the rostral pontine region with the septo-hippocampal pathways. In our previous studies we have demonstrated that posterior hypothalamic region was able to generate the cholinergically-induced type 2 theta rhythm in both in vitro and in vivo conditions. The purpose of the present study was to evoke theta-band oscillations in PH area using the glutamatergic agonist – kainic acid. We have shown that application of kainic acid resulted in the generation of well-synchronized theta activity in PH slices maintained in vitro as well as enhancement of spontaneous theta recorded from posterior hypothalamic region of anaesthetized rat. Mechanisms underlying the generation of glutamatergically-induced theta oscillations in both in vitro and in vivo posterior hypothalamus are discussed. Supported by NCN grant no. 2011/01/B/NZ4/00373.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 2
• Opis fizyczny: p.201

Twórcy

autor

Kowalczyk T.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Bocian R.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Caban B.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Golebiewski H.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Kazmierska P.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Konopacki J.

• Department of Neurobiology, University of Lodz, Lodz, Poland

Uwagi

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